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Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)

(2015) CLINICAL ENDOCRINOLOGY. 83(6). p.902-912
Author
Organization
Abstract
Objective: To study the association between serum anti-Mullerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5.2-12.1 mu g/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol. Design: Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5.0-14.9 pmol/l; higher stratum: 15.0-44.9 pmol/l). Patients: Infertile women of good prognosis (n = 265). Measurements: Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH. Results: Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0.001) positive dose responses were observed for the number of follicles >= 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients. Conclusions: Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.
Keywords
RESERVE, ANTAGONIST PROTOCOL, RESPONDERS, MARKERS, INDIVIDUALIZATION, ANTIMULLERIAN HORMONE, INHIBIN-B, CONTROLLED OVARIAN STIMULATION, IN-VITRO FERTILIZATION, EFFICACY

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MLA
Bosch, Ernesto et al. “Follicular and Endocrine Dose Responses According to anti-Müllerian Hormone Levels in IVF Patients Treated with a Novel Human Recombinant FSH (FE 999049).” CLINICAL ENDOCRINOLOGY 83.6 (2015): 902–912. Print.
APA
Bosch, E., Andersen, A. N., Barri, P., García-Velasco, J. A., De Sutter, P., Fernández-Sánchez, M., Visnova, H., et al. (2015). Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049). CLINICAL ENDOCRINOLOGY, 83(6), 902–912.
Chicago author-date
Bosch, Ernesto, Anders Nyboe Andersen, Pedro Barri, Juan Antonio García-Velasco, Petra De Sutter, Manuel Fernández-Sánchez, Hana Visnova, Bjarke M Klein, Bernadette Mannaerts, and Joan-Carles Arce. 2015. “Follicular and Endocrine Dose Responses According to anti-Müllerian Hormone Levels in IVF Patients Treated with a Novel Human Recombinant FSH (FE 999049).” Clinical Endocrinology 83 (6): 902–912.
Chicago author-date (all authors)
Bosch, Ernesto, Anders Nyboe Andersen, Pedro Barri, Juan Antonio García-Velasco, Petra De Sutter, Manuel Fernández-Sánchez, Hana Visnova, Bjarke M Klein, Bernadette Mannaerts, and Joan-Carles Arce. 2015. “Follicular and Endocrine Dose Responses According to anti-Müllerian Hormone Levels in IVF Patients Treated with a Novel Human Recombinant FSH (FE 999049).” Clinical Endocrinology 83 (6): 902–912.
Vancouver
1.
Bosch E, Andersen AN, Barri P, García-Velasco JA, De Sutter P, Fernández-Sánchez M, et al. Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049). CLINICAL ENDOCRINOLOGY. 2015;83(6):902–12.
IEEE
[1]
E. Bosch et al., “Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049),” CLINICAL ENDOCRINOLOGY, vol. 83, no. 6, pp. 902–912, 2015.
@article{7077685,
  abstract     = {Objective: To study the association between serum anti-Mullerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5.2-12.1 mu g/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in a GnRH antagonist protocol. 
Design: Secondary analysis of a randomized controlled trial with stratified randomization according to AMH (lower stratum: 5.0-14.9 pmol/l; higher stratum: 15.0-44.9 pmol/l). 
Patients: Infertile women of good prognosis (n = 265). 
Measurements: Follicular development and endocrine parameters during controlled ovarian stimulation (COS) with rhFSH. 
Results: Serum FSH levels increased with increasing rhFSH doses and steady-state levels for each dose were similar in both AMH strata. In the whole study population, significant (P < 0.001) positive dose responses were observed for the number of follicles >= 12 mm, and serum levels of oestradiol, inhibin B, inhibin A and progesterone at end of stimulation. In comparison with the higher AMH stratum, patients in the lower AMH stratum had significantly different slopes of the dose-response curves for these hormones, and no clear dose-related increase was observed for the number of follicles in these patients. 
Conclusions: Dose-response relationships between rhFSH and follicular development and endocrine parameters are significantly different for IVF/ICSI patients with lower and higher serum AMH levels at start of COS.},
  author       = {Bosch, Ernesto and Andersen, Anders Nyboe and Barri, Pedro and García-Velasco, Juan Antonio and De Sutter, Petra and Fernández-Sánchez, Manuel and Visnova, Hana and Klein, Bjarke M and Mannaerts, Bernadette and Arce, Joan-Carles},
  issn         = {0300-0664},
  journal      = {CLINICAL ENDOCRINOLOGY},
  keywords     = {RESERVE,ANTAGONIST PROTOCOL,RESPONDERS,MARKERS,INDIVIDUALIZATION,ANTIMULLERIAN HORMONE,INHIBIN-B,CONTROLLED OVARIAN STIMULATION,IN-VITRO FERTILIZATION,EFFICACY},
  language     = {eng},
  number       = {6},
  pages        = {902--912},
  title        = {Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049)},
  url          = {http://dx.doi.org/10.1111/cen.12864},
  volume       = {83},
  year         = {2015},
}

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