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Diffusion Kurtosis imaging: a possible MRI biomarker for AD diagnosis?

(2015) JOURNAL OF ALZHEIMERS DISEASE. 48(4). p.937-948
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Abstract
The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimer's disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age-and gender-matched patients with mild cognitive impairment (MCI) due to AD (n = 18), dementia due to AD (n = 19), and age-matched cognitively healthy controls (n = 14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.
Keywords
ALZHEIMERS ASSOCIATION WORKGROUPS, magnetic resonance imaging, DIFFERENTIAL DEMENTIA DIAGNOSIS, GAUSSIAN WATER DIFFUSION, WHITE-MATTER INTEGRITY, NATIONAL INSTITUTE, CONFIRMED DEMENTIA, MUTUAL INFORMATION, CORPUS-CALLOSUM, Alzheimer's disease, HUMAN BRAIN, biomarker, diffusion kurtosis imaging, MILD COGNITIVE IMPAIRMENT, diffusion tensor imaging, early diagnosis, mild cognitive impairment

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MLA
Struyfs, H et al. “Diffusion Kurtosis Imaging: a Possible MRI Biomarker for AD Diagnosis?” JOURNAL OF ALZHEIMERS DISEASE 48.4 (2015): 937–948. Print.
APA
Struyfs, H., Van Hecke, W., Veraart, J., Sijbers, J., Slaets, S., De Belder, M., Wuyts, L., et al. (2015). Diffusion Kurtosis imaging: a possible MRI biomarker for AD diagnosis? JOURNAL OF ALZHEIMERS DISEASE, 48(4), 937–948.
Chicago author-date
Struyfs, H, W Van Hecke, J Veraart, J Sijbers, S Slaets, Maya De Belder, L Wuyts, et al. 2015. “Diffusion Kurtosis Imaging: a Possible MRI Biomarker for AD Diagnosis?” Journal of Alzheimers Disease 48 (4): 937–948.
Chicago author-date (all authors)
Struyfs, H, W Van Hecke, J Veraart, J Sijbers, S Slaets, Maya De Belder, L Wuyts, B Peters, K Sleegers, C Robberecht, C Van Broeckhoven, F De Belder, PM Parizel, and S Engelborghs. 2015. “Diffusion Kurtosis Imaging: a Possible MRI Biomarker for AD Diagnosis?” Journal of Alzheimers Disease 48 (4): 937–948.
Vancouver
1.
Struyfs H, Van Hecke W, Veraart J, Sijbers J, Slaets S, De Belder M, et al. Diffusion Kurtosis imaging: a possible MRI biomarker for AD diagnosis? JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS; 2015;48(4):937–48.
IEEE
[1]
H. Struyfs et al., “Diffusion Kurtosis imaging: a possible MRI biomarker for AD diagnosis?,” JOURNAL OF ALZHEIMERS DISEASE, vol. 48, no. 4, pp. 937–948, 2015.
@article{7073348,
  abstract     = {The purpose of this explorative study was to investigate whether diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white matter integrity changes in Alzheimer's disease (AD) patients using a whole brain voxel-based analysis (VBA). Therefore, age-and gender-matched patients with mild cognitive impairment (MCI) due to AD (n = 18), dementia due to AD (n = 19), and age-matched cognitively healthy controls (n = 14) were prospectively included. The magnetic resonance imaging protocol included routine structural brain imaging and DKI. Datasets were transformed to a population-specific atlas space. Groups were compared using VBA. Differences in diffusion and mean kurtosis measures between MCI and AD patients and controls were shown, and were mainly found in the splenium of the corpus callosum and the corona radiata. Hence, DTI and DKI parameter changes are suggestive of white matter changes in AD.},
  author       = {Struyfs, H and Van Hecke, W and Veraart, J and Sijbers, J and Slaets, S and De Belder, Maya and Wuyts, L and Peters, B and Sleegers, K and Robberecht, C and Van Broeckhoven, C and De Belder, F and Parizel, PM and Engelborghs, S},
  issn         = {1387-2877},
  journal      = {JOURNAL OF ALZHEIMERS DISEASE},
  keywords     = {ALZHEIMERS ASSOCIATION WORKGROUPS,magnetic resonance imaging,DIFFERENTIAL DEMENTIA DIAGNOSIS,GAUSSIAN WATER DIFFUSION,WHITE-MATTER INTEGRITY,NATIONAL INSTITUTE,CONFIRMED DEMENTIA,MUTUAL INFORMATION,CORPUS-CALLOSUM,Alzheimer's disease,HUMAN BRAIN,biomarker,diffusion kurtosis imaging,MILD COGNITIVE IMPAIRMENT,diffusion tensor imaging,early diagnosis,mild cognitive impairment},
  language     = {eng},
  number       = {4},
  pages        = {937--948},
  publisher    = {IOS PRESS},
  title        = {Diffusion Kurtosis imaging: a possible MRI biomarker for AD diagnosis?},
  url          = {http://dx.doi.org/10.3233/JAD-150253},
  volume       = {48},
  year         = {2015},
}

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