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Prevention of SHIV transmission by topical IFN-β treatment

(2016) MUCOSAL IMMUNOLOGY. 9(6). p.1528-1536
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Abstract
Understanding vaginal and rectal HIV transmission and protective cellular and molecular mechanisms is critical for designing new prevention strategies, including those required for an effective vaccine. The determinants of protection against HIV infection are, however, poorly understood. Increasing evidence suggest that innate immune defenses may help protect mucosal surfaces from HIV transmission in highly exposed, uninfected subjects. More recent studies suggest that systemically administered type 1 interferon protects against simian immunodeficiency virus infection of macaques. Herewe hypothesized that topically applied type 1 interferons might stimulate vaginal innate responses that could protect against HIV transmission. We therefore applied a recombinant human type 1 interferon (IFN-b) to the vagina of rhesus macaques and vaginally challenged them with pathogenic simian/human immunodeficiency virus (SHIV). Vaginal administration of IFN-b resulted in marked local changes in immune cell phenotype, increasing immune activation and HIV co-receptor expression, yet provided significant protection from SHIV acquisition as interferon response genes were also upregulated. These data suggest that protection from vaginal HIV acquisition may be achieved by activating innate mucosal defenses.
Keywords
SIMIAN IMMUNODEFICIENCY VIRUS, INNATE IMMUNE-RESPONSE, HIV-1 INFECTION, RHESUS MACAQUES, T-CELLS, GENETIC-VARIATION, INTERFERON-ALPHA, SIV INFECTION, I INTERFERON, EXPRESSION

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Citation

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Chicago
Veazey, RS, HA Pilch Cooper, TJ Hope, G Alter, AM Carias, Magdalena Sips, X Wang, et al. 2016. “Prevention of SHIV Transmission by Topical IFN-β Treatment.” Mucosal Immunology 9 (6): 1528–1536.
APA
Veazey, R., Pilch Cooper, H., Hope, T., Alter, G., Carias, A., Sips, M., Wang, X., et al. (2016). Prevention of SHIV transmission by topical IFN-β treatment. MUCOSAL IMMUNOLOGY, 9(6), 1528–1536.
Vancouver
1.
Veazey R, Pilch Cooper H, Hope T, Alter G, Carias A, Sips M, et al. Prevention of SHIV transmission by topical IFN-β treatment. MUCOSAL IMMUNOLOGY. 2016;9(6):1528–36.
MLA
Veazey, RS, HA Pilch Cooper, TJ Hope, et al. “Prevention of SHIV Transmission by Topical IFN-β Treatment.” MUCOSAL IMMUNOLOGY 9.6 (2016): 1528–1536. Print.
@article{7072191,
  abstract     = {Understanding vaginal and rectal HIV transmission and protective cellular and molecular mechanisms is critical for designing new prevention strategies, including those required for an effective vaccine. The determinants of protection against HIV infection are, however, poorly understood. Increasing evidence suggest that innate immune defenses may help protect mucosal surfaces from HIV transmission in highly exposed, uninfected subjects. More recent studies suggest that systemically administered type 1 interferon protects against simian immunodeficiency virus infection of macaques. Herewe hypothesized that topically applied type 1 interferons might stimulate vaginal innate responses that could protect against HIV transmission. We therefore applied a recombinant human type 1 interferon (IFN-b) to the vagina of rhesus macaques and vaginally challenged them with pathogenic simian/human immunodeficiency virus (SHIV). Vaginal administration of IFN-b resulted in marked local changes in immune cell phenotype, increasing immune activation and HIV co-receptor expression, yet provided significant protection from SHIV acquisition as interferon response genes were also upregulated. These data suggest that protection from vaginal HIV acquisition may be achieved by activating innate mucosal defenses.},
  author       = {Veazey, RS and Pilch Cooper, HA and Hope, TJ and Alter, G and Carias, AM and Sips, Magdalena and Wang, X and Rodriguez, B and Sieg, SF and Reich, A and Wilkinson, P and Cameron, MJ and Lederman, MM},
  issn         = {1933-0219},
  journal      = {MUCOSAL IMMUNOLOGY},
  language     = {eng},
  number       = {6},
  pages        = {1528--1536},
  title        = {Prevention of SHIV transmission by topical IFN-\ensuremath{\beta} treatment},
  url          = {http://dx.doi.org/10.1038/mi.2015.146},
  volume       = {9},
  year         = {2016},
}

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