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Role of NK cells in immunotherapy and virotherapy of solid tumors

(2015) IMMUNOTHERAPY. 7(8). p.861-882
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Abstract
Although natural killer (NK) cells are endowed with powerful cytolytic activity against cancer cells, their role in different therapies against solid tumors has not yet been fully elucidated. Their interactions with various elements of the tumor microenvironment as well as their possible effects in contributing to and/or limiting oncolytic virotherapy render this potential immunotherapeutic tool still difficult to exploit at the bedside. Here, we will review the current literature with the aim of providing new hints to manage this powerful cell type in future innovative therapies, such as the use of NK cells in combination with new cytokines, specific mAbs (inducing ADCC), Tyr-Kinase inhibitors, immunomodulatory drugs and/or the design of oncolytic viruses aimed at optimizing the effect of NK cells in virotherapy.
Keywords
solid tumor, NK cells, tumor escape, immunotherapy, tumor microenvironment, virotherapy, NATURAL-KILLER-CELLS, VIRUS-INFECTED CELLS, VESICULAR STOMATITIS-VIRUS, REGULATORY T-CELLS, HUMAN CYTOMEGALOVIRUS-INFECTION, CYTOTOXICITY RECEPTOR NKP44, MEDIATED ANTITUMOR IMMUNITY, NEWCASTLE-DISEASE VIRUS, HEPATITIS-C VIRIONS, MHC CLASS-I

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Citation

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MLA
Cantoni, Claudia, et al. “Role of NK Cells in Immunotherapy and Virotherapy of Solid Tumors.” IMMUNOTHERAPY, vol. 7, no. 8, 2015, pp. 861–82, doi:10.2217/imt.15.53.
APA
Cantoni, C., Grauwet, K., Pietra, G., Parodi, M., Mingari, M. C., De Maria, A., … Vitale, M. (2015). Role of NK cells in immunotherapy and virotherapy of solid tumors. IMMUNOTHERAPY, 7(8), 861–882. https://doi.org/10.2217/imt.15.53
Chicago author-date
Cantoni, Claudia, Korneel Grauwet, Gabriella Pietra, Monica Parodi, Maria Cristina Mingari, Andrea De Maria, Herman Favoreel, and Massimo Vitale. 2015. “Role of NK Cells in Immunotherapy and Virotherapy of Solid Tumors.” IMMUNOTHERAPY 7 (8): 861–82. https://doi.org/10.2217/imt.15.53.
Chicago author-date (all authors)
Cantoni, Claudia, Korneel Grauwet, Gabriella Pietra, Monica Parodi, Maria Cristina Mingari, Andrea De Maria, Herman Favoreel, and Massimo Vitale. 2015. “Role of NK Cells in Immunotherapy and Virotherapy of Solid Tumors.” IMMUNOTHERAPY 7 (8): 861–882. doi:10.2217/imt.15.53.
Vancouver
1.
Cantoni C, Grauwet K, Pietra G, Parodi M, Mingari MC, De Maria A, et al. Role of NK cells in immunotherapy and virotherapy of solid tumors. IMMUNOTHERAPY. 2015;7(8):861–82.
IEEE
[1]
C. Cantoni et al., “Role of NK cells in immunotherapy and virotherapy of solid tumors,” IMMUNOTHERAPY, vol. 7, no. 8, pp. 861–882, 2015.
@article{7072115,
  abstract     = {{Although natural killer (NK) cells are endowed with powerful cytolytic activity against cancer cells, their role in different therapies against solid tumors has not yet been fully elucidated. Their interactions with various elements of the tumor microenvironment as well as their possible effects in contributing to and/or limiting oncolytic virotherapy render this potential immunotherapeutic tool still difficult to exploit at the bedside. Here, we will review the current literature with the aim of providing new hints to manage this powerful cell type in future innovative therapies, such as the use of NK cells in combination with new cytokines, specific mAbs (inducing ADCC), Tyr-Kinase inhibitors, immunomodulatory drugs and/or the design of oncolytic viruses aimed at optimizing the effect of NK cells in virotherapy.}},
  author       = {{Cantoni, Claudia and Grauwet, Korneel and Pietra, Gabriella and Parodi, Monica and Mingari, Maria Cristina and De Maria, Andrea and Favoreel, Herman and Vitale, Massimo}},
  issn         = {{1750-743X}},
  journal      = {{IMMUNOTHERAPY}},
  keywords     = {{solid tumor,NK cells,tumor escape,immunotherapy,tumor microenvironment,virotherapy,NATURAL-KILLER-CELLS,VIRUS-INFECTED CELLS,VESICULAR STOMATITIS-VIRUS,REGULATORY T-CELLS,HUMAN CYTOMEGALOVIRUS-INFECTION,CYTOTOXICITY RECEPTOR NKP44,MEDIATED ANTITUMOR IMMUNITY,NEWCASTLE-DISEASE VIRUS,HEPATITIS-C VIRIONS,MHC CLASS-I}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{861--882}},
  title        = {{Role of NK cells in immunotherapy and virotherapy of solid tumors}},
  url          = {{http://doi.org/10.2217/imt.15.53}},
  volume       = {{7}},
  year         = {{2015}},
}

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