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Synthetic entries to and biological activity of pyrrolopyrimidines

(2015) CHEMICAL REVIEWS. 116(1). p.80-139
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IWT/100014/SBO
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BOFDC12014001101
Abstract
This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers: pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.
Keywords
ADENOSINE-KINASE-INHIBITORS, PURINE NUCLEOSIDE PHOSPHORYLASE, TRANSITION-STATE ANALOGS, SELECTIVE ALPHA(1)-ADRENOCEPTOR LIGANDS, COUPLED FOLATE TRANSPORTER, STRUCTURE-BASED DESIGN, VIRUS-RNA REPLICATION, DIELS-ALDER REACTION, ONE-POT SYNTHESIS, GYRASE B GYRB

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Citation

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MLA
De Coen, Laurens et al. “Synthetic Entries to and Biological Activity of Pyrrolopyrimidines.” CHEMICAL REVIEWS 116.1 (2015): 80–139. Print.
APA
De Coen, L., Heugebaert, T., Garcia Jimenez, D., & Stevens, C. (2015). Synthetic entries to and biological activity of pyrrolopyrimidines. CHEMICAL REVIEWS, 116(1), 80–139.
Chicago author-date
De Coen, Laurens, Thomas Heugebaert, Daniel Garcia Jimenez, and Christian Stevens. 2015. “Synthetic Entries to and Biological Activity of Pyrrolopyrimidines.” Chemical Reviews 116 (1): 80–139.
Chicago author-date (all authors)
De Coen, Laurens, Thomas Heugebaert, Daniel Garcia Jimenez, and Christian Stevens. 2015. “Synthetic Entries to and Biological Activity of Pyrrolopyrimidines.” Chemical Reviews 116 (1): 80–139.
Vancouver
1.
De Coen L, Heugebaert T, Garcia Jimenez D, Stevens C. Synthetic entries to and biological activity of pyrrolopyrimidines. CHEMICAL REVIEWS. 2015;116(1):80–139.
IEEE
[1]
L. De Coen, T. Heugebaert, D. Garcia Jimenez, and C. Stevens, “Synthetic entries to and biological activity of pyrrolopyrimidines,” CHEMICAL REVIEWS, vol. 116, no. 1, pp. 80–139, 2015.
@article{7070878,
  abstract     = {This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring, and their corresponding nucleosides display a broad applicability in medicinal chemistry. This overview is divided into three main sections, according to the respective isomers: pyrrolo[2,3-d]pyrimidines, pyrrolo[3,2-d]pyrimidines, and pyrrolo[3,4-d]pyrimidines. Each section contains a description of common retro-synthetic strategies, with particular attention for newly reported synthetic entries to the scaffold. Next, the synthetic strategies and the ways in which the scaffolds can be further modified are exemplified according to the biological properties of the obtained products.},
  author       = {De Coen, Laurens and Heugebaert, Thomas and Garcia Jimenez, Daniel and Stevens, Christian},
  issn         = {0009-2665},
  journal      = {CHEMICAL REVIEWS},
  keywords     = {ADENOSINE-KINASE-INHIBITORS,PURINE NUCLEOSIDE PHOSPHORYLASE,TRANSITION-STATE ANALOGS,SELECTIVE ALPHA(1)-ADRENOCEPTOR LIGANDS,COUPLED FOLATE TRANSPORTER,STRUCTURE-BASED DESIGN,VIRUS-RNA REPLICATION,DIELS-ALDER REACTION,ONE-POT SYNTHESIS,GYRASE B GYRB},
  language     = {eng},
  number       = {1},
  pages        = {80--139},
  title        = {Synthetic entries to and biological activity of pyrrolopyrimidines},
  url          = {http://dx.doi.org/10.1021/acs.chemrev.5b00483},
  volume       = {116},
  year         = {2015},
}

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