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Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

(2015) CHEMICAL COMMUNICATIONS. 51(48). p.9868-9871
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Abstract
A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]-benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the identification of three representatives as potent and selective HDAC6 inhibitors. Further tests with regard to inflammatory responses indicated that HDAC6 inhibition can be uncoupled from transcriptional inhibition at the level of activated NF-kappa B, AP-1, and GR.
Keywords
TUBASTATIN, MUTAGENICITY, HISTONE DEACETYLASE INHIBITORS, ISOFORM

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Citation

Please use this url to cite or link to this publication:

Chicago
De Vreese, Rob, Nicholas Van Steen, Tom Verhaeghe, Tom Desmet, Nadia Bougarne, Karolien De Bosscher, Veronick Benoy, Wanda Haeck, Ludo Van Den Bosch, and Matthias D’hooghe. 2015. “Synthesis of Benzothiophene-based Hydroxamic Acids as Potent and Selective HDAC6 Inhibitors.” Chemical Communications 51 (48): 9868–9871.
APA
De Vreese, R., Van Steen, N., Verhaeghe, T., Desmet, T., Bougarne, N., De Bosscher, K., Benoy, V., et al. (2015). Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors. CHEMICAL COMMUNICATIONS, 51(48), 9868–9871.
Vancouver
1.
De Vreese R, Van Steen N, Verhaeghe T, Desmet T, Bougarne N, De Bosscher K, et al. Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors. CHEMICAL COMMUNICATIONS. 2015;51(48):9868–71.
MLA
De Vreese, Rob, Nicholas Van Steen, Tom Verhaeghe, et al. “Synthesis of Benzothiophene-based Hydroxamic Acids as Potent and Selective HDAC6 Inhibitors.” CHEMICAL COMMUNICATIONS 51.48 (2015): 9868–9871. Print.
@article{7070693,
  abstract     = {A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]-benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the identification of three representatives as potent and selective HDAC6 inhibitors. Further tests with regard to inflammatory responses indicated that HDAC6 inhibition can be uncoupled from transcriptional inhibition at the level of activated NF-kappa B, AP-1, and GR.},
  author       = {De Vreese, Rob and Van Steen, Nicholas and Verhaeghe, Tom and Desmet, Tom and Bougarne, Nadia and De Bosscher, Karolien and Benoy, Veronick and Haeck, Wanda and Van Den Bosch, Ludo and D'hooghe, Matthias},
  issn         = {1359-7345},
  journal      = {CHEMICAL COMMUNICATIONS},
  language     = {eng},
  number       = {48},
  pages        = {9868--9871},
  title        = {Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors},
  url          = {http://dx.doi.org/10.1039/C5CC03295D},
  volume       = {51},
  year         = {2015},
}

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