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Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones

(2015) SYNLETT. 26(9). p.1195-2000
Author
Organization
Abstract
3-Arylamino-1-ferrocenylpropan-1-ones, prepared through aza-Michael addition of aromatic amines to 1-ferrocenylpropenone, were transformed into the corresponding 1,3-amino alcohols upon NaBH4-mediated carbonyl reduction. The latter amino alcohols were deployed as eligible substrates for the synthesis of a variety of ferrocene-containing heterocycles including 1,3-oxazinanes, 1,3-oxazinan-2-ones, and tetrahydropyrimidin-2-ones, which were subsequently evaluated for their antimicrobial and cytotoxic activities.
Keywords
STRUCTURAL-CHARACTERIZATION, amino alcohols, STEREOSELECTIVE-SYNTHESIS, RING TRANSFORMATION, ORGANIC-SYNTHESIS, INDOLE HYBRIDS, DERIVATIVES, INHIBITORS, ANALOGS, MAYTANSINOIDS, PIPERIDINES, ferrocenes, heterocycles, oxazinanes, oxazinan-2-ones, tetrahydropyrimidin-2-ones, cyclization

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Citation

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MLA
Pejović, Anka et al. “Synthesis and Antimicrobial/cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones.” SYNLETT 26.9 (2015): 1195–2000. Print.
APA
Pejović, A., Danneels, B., Desmet, T., Thi Cham, B., Van Nguyen, T., Radulović, N. S., Vukicević, R. D., et al. (2015). Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones. SYNLETT, 26(9), 1195–2000.
Chicago author-date
Pejović, Anka, Barbara Danneels, Tom Desmet, Ba Thi Cham, Tuyen Van Nguyen, Niko S Radulović, Rastko D Vukicević, and Matthias D’hooghe. 2015. “Synthesis and Antimicrobial/cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones.” Synlett 26 (9): 1195–2000.
Chicago author-date (all authors)
Pejović, Anka, Barbara Danneels, Tom Desmet, Ba Thi Cham, Tuyen Van Nguyen, Niko S Radulović, Rastko D Vukicević, and Matthias D’hooghe. 2015. “Synthesis and Antimicrobial/cytotoxic Assessment of Ferrocenyl Oxazinanes, Oxazinan-2-ones, and Tetrahydropyrimidin-2-ones.” Synlett 26 (9): 1195–2000.
Vancouver
1.
Pejović A, Danneels B, Desmet T, Thi Cham B, Van Nguyen T, Radulović NS, et al. Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones. SYNLETT. 2015;26(9):1195–2000.
IEEE
[1]
A. Pejović et al., “Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones,” SYNLETT, vol. 26, no. 9, pp. 1195–2000, 2015.
@article{7070657,
  abstract     = {3-Arylamino-1-ferrocenylpropan-1-ones, prepared through aza-Michael addition of aromatic amines to 1-ferrocenylpropenone, were transformed into the corresponding 1,3-amino alcohols upon NaBH4-mediated carbonyl reduction. The latter amino alcohols were deployed as eligible substrates for the synthesis of a variety of ferrocene-containing heterocycles including 1,3-oxazinanes, 1,3-oxazinan-2-ones, and tetrahydropyrimidin-2-ones, which were subsequently evaluated for their antimicrobial and cytotoxic activities.},
  author       = {Pejović, Anka and Danneels, Barbara and Desmet, Tom and Thi Cham, Ba and Van Nguyen, Tuyen and Radulović, Niko S and Vukicević, Rastko D and D'hooghe, Matthias},
  issn         = {0936-5214},
  journal      = {SYNLETT},
  keywords     = {STRUCTURAL-CHARACTERIZATION,amino alcohols,STEREOSELECTIVE-SYNTHESIS,RING TRANSFORMATION,ORGANIC-SYNTHESIS,INDOLE HYBRIDS,DERIVATIVES,INHIBITORS,ANALOGS,MAYTANSINOIDS,PIPERIDINES,ferrocenes,heterocycles,oxazinanes,oxazinan-2-ones,tetrahydropyrimidin-2-ones,cyclization},
  language     = {eng},
  number       = {9},
  pages        = {1195--2000},
  title        = {Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones},
  url          = {http://dx.doi.org/10.1055/s-0034-1380348},
  volume       = {26},
  year         = {2015},
}

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