Advanced search
1 file | 235.27 KB Add to list

The CODATwins project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits

Author
Organization
Abstract
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
Keywords
height, BMI, twins, heritability, international comparisons, BODY-MASS INDEX, GENOME-WIDE ASSOCIATION, HUMAN OBESITY, ADOLESCENT DEVELOPMENT, SWEDISH TWIN, HEALTHY TWIN, ADULT HEIGHT, REARED APART, 8 COUNTRIES, REGISTRY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 235.27 KB

Citation

Please use this url to cite or link to this publication:

MLA
Silventoinen, Karri et al. “The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.” TWIN RESEARCH AND HUMAN GENETICS 18.4 (2015): 348–360. Print.
APA
Silventoinen, K., Jelenkovic, A., Sund, R., Honda, C., Aaltonen, S., Yokoyama, Y., Tarnoki, A. D., et al. (2015). The CODATwins project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits. TWIN RESEARCH AND HUMAN GENETICS, 18(4), 348–360.
Chicago author-date
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D Tarnoki, et al. 2015. “The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.” Twin Research and Human Genetics 18 (4): 348–360.
Chicago author-date (all authors)
Silventoinen, Karri, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D Tarnoki, David L Tarnoki, Feng Ning, Fuling Ji, Zengchang Pang, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams, Thalia C Eley, Alice M Gregory, Kimberly J Saudino, Lise Dubois, Michel Boivin, Claire MA Haworth, Robert Plomin, Sevgi Y Öncel, Fazil Aliev, Maria A Stazi, Corrado Fagnani, Cristina D’Ippolito, Jeffrey M Craig, Richard Saffery, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L Freitas, José Antonio Maia, K Paige Harden, Elliot M Tucker-Drob, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Changhee Hong, Youngsook Chong, Catherine Derom, Robert F Vlietinck, Ruth JF Loos, Wendy Cozen, Amie E Hwang, Thomas M Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Kelly Aujard, Patrik KE Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkilä, Qihua Tan, Dongfeng Zhang, Gary E Swan, Ruth Krasnow, Kerry L Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F. Krueger, Matt Mcgue, Shandell Pahlen, Per Tynelius, Glen E Duncan, Dedra Buchwald, Robin P Corley, Brooke M Huibregtse, Tracy L Nelson, Keith E Whitfield, Carol E Franz, William S Kremen, Michael J Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos CEM van Beijsterveldt, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G Martin, Yoshinori Iwatani, Kazuo Hayakawa, Finn Rasmussen, Joohon Sung, Jennifer R Harris, Gonneke Willemsen, Andreas Busjahn, Jack H Goldberg, Dorret I Boomsma, Yoon-Mi Hur, Thorkild IA Sorensen, and Jaakko Kaprio. 2015. “The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-environmental Variation in Genetic and Environmental Effects on Anthropometric Traits.” Twin Research and Human Genetics 18 (4): 348–360.
Vancouver
1.
Silventoinen K, Jelenkovic A, Sund R, Honda C, Aaltonen S, Yokoyama Y, et al. The CODATwins project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits. TWIN RESEARCH AND HUMAN GENETICS. 2015;18(4):348–60.
IEEE
[1]
K. Silventoinen et al., “The CODATwins project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits,” TWIN RESEARCH AND HUMAN GENETICS, vol. 18, no. 4, pp. 348–360, 2015.
@article{7068686,
  abstract     = {{For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.}},
  author       = {{Silventoinen, Karri and Jelenkovic, Aline and Sund, Reijo and Honda, Chika and Aaltonen, Sari and Yokoyama, Yoshie and Tarnoki, Adam D and Tarnoki, David L and Ning, Feng and Ji, Fuling and Pang, Zengchang and Ordoñana, Juan R and Sánchez-Romera, Juan F and Colodro-Conde, Lucia and Burt, S Alexandra and Klump, Kelly L and Medland, Sarah E and Montgomery, Grant W and Kandler, Christian and McAdams, Tom A and Eley, Thalia C and Gregory, Alice M and Saudino, Kimberly J and Dubois, Lise and Boivin, Michel and Haworth, Claire MA and Plomin, Robert and Öncel, Sevgi Y and Aliev, Fazil and Stazi, Maria A and Fagnani, Corrado and D'Ippolito, Cristina and Craig, Jeffrey M and Saffery, Richard and Siribaddana, Sisira H and Hotopf, Matthew and Sumathipala, Athula and Spector, Timothy and Mangino, Massimo and Lachance, Genevieve and Gatz, Margaret and Butler, David A and Bayasgalan, Gombojav and Narandalai, Danshiitsoodol and Freitas, Duarte L and Maia, José Antonio and Harden, K Paige and Tucker-Drob, Elliot M and Christensen, Kaare and Skytthe, Axel and Kyvik, Kirsten O and Hong, Changhee and Chong, Youngsook and Derom, Catherine and Vlietinck, Robert F and Loos, Ruth JF and Cozen, Wendy and Hwang, Amie E and Mack, Thomas M and He, Mingguang and Ding, Xiaohu and Chang, Billy and Silberg, Judy L and Eaves, Lindon J and Maes, Hermine H and Cutler, Tessa L and Hopper, John L and Aujard, Kelly and Magnusson, Patrik KE and Pedersen, Nancy L and Aslan, Anna K Dahl and Song, Yun-Mi and Yang, Sarah and Lee, Kayoung and Baker, Laura A and Tuvblad, Catherine and Bjerregaard-Andersen, Morten and Beck-Nielsen, Henning and Sodemann, Morten and Heikkilä, Kauko and Tan, Qihua and Zhang, Dongfeng and Swan, Gary E and Krasnow, Ruth and Jang, Kerry L and Knafo-Noam, Ariel and Mankuta, David and Abramson, Lior and Lichtenstein, Paul and Krueger, Robert F. and Mcgue, Matt and Pahlen, Shandell and Tynelius, Per and Duncan, Glen E and Buchwald, Dedra and Corley, Robin P and Huibregtse, Brooke M and Nelson, Tracy L and Whitfield, Keith E and Franz, Carol E and Kremen, William S and Lyons, Michael J and Ooki, Syuichi and Brandt, Ingunn and Nilsen, Thomas Sevenius and Inui, Fujio and Watanabe, Mikio and Bartels, Meike and van Beijsterveldt, Toos CEM and Wardle, Jane and Llewellyn, Clare H and Fisher, Abigail and Rebato, Esther and Martin, Nicholas G and Iwatani, Yoshinori and Hayakawa, Kazuo and Rasmussen, Finn and Sung, Joohon and Harris, Jennifer R and Willemsen, Gonneke and Busjahn, Andreas and Goldberg, Jack H and Boomsma, Dorret I and Hur, Yoon-Mi and Sorensen, Thorkild IA and Kaprio, Jaakko}},
  issn         = {{1832-4274}},
  journal      = {{TWIN RESEARCH AND HUMAN GENETICS}},
  keywords     = {{height,BMI,twins,heritability,international comparisons,BODY-MASS INDEX,GENOME-WIDE ASSOCIATION,HUMAN OBESITY,ADOLESCENT DEVELOPMENT,SWEDISH TWIN,HEALTHY TWIN,ADULT HEIGHT,REARED APART,8 COUNTRIES,REGISTRY}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{348--360}},
  title        = {{The CODATwins project: the cohort description of collaborative project of development of anthropometrical measures in twins to study macro-environmental variation in genetic and environmental effects on anthropometric traits}},
  url          = {{http://dx.doi.org/10.1017/thg.2015.29}},
  volume       = {{18}},
  year         = {{2015}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: