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Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Thi Hang Dao (UGent) , Lena Decuyper (UGent) , Karen Mollet (UGent) , Sara Kenis (UGent) , Norbert De Kimpe (UGent) , Tuyen Van Nguyen and Matthias D'hooghe (UGent)
(2016) SYNLETT. 27(7). p.1100-1105
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Abstract
This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, and 1,3-oxazinan-2-ones. This -lactam building block approach provides a convenient new entry into trifluoromethylated scaffolds as useful synthetic intermediates en route to a variety of CF3-functionalized target structures.
Keywords
beta-lactams, azetidines, aminopropanes, oxazinanes, fluorine, CF3, :BETA-AMINO-ACID, STEREOSELECTIVE-SYNTHESIS, STRAIGHTFORWARD SYNTHESIS, RING TRANSFORMATION, STAUDINGER REACTION, CONTINUOUS-FLOW, HETEROCYCLES, INHIBITORS, PROTEASE, 2-AZETIDINONES

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Citation

Please use this url to cite or link to this publication:

MLA
Dao, Thi Hang et al. “Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones Starting from 4-trifluoromethyl-β-lactam Building Blocks.” SYNLETT 27.7 (2016): 1100–1105. Print.
APA
Dao, T. H., Decuyper, L., Mollet, K., Kenis, S., De Kimpe, N., Van Nguyen, T., & D’hooghe, M. (2016). Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks. SYNLETT, 27(7), 1100–1105.
Chicago author-date
Dao, Thi Hang, Lena Decuyper, Karen Mollet, Sara Kenis, Norbert De Kimpe, Tuyen Van Nguyen, and Matthias D’hooghe. 2016. “Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones Starting from 4-trifluoromethyl-β-lactam Building Blocks.” Synlett 27 (7): 1100–1105.
Chicago author-date (all authors)
Dao, Thi Hang, Lena Decuyper, Karen Mollet, Sara Kenis, Norbert De Kimpe, Tuyen Van Nguyen, and Matthias D’hooghe. 2016. “Synthesis of Trifluoromethylated Azetidines, Aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones Starting from 4-trifluoromethyl-β-lactam Building Blocks.” Synlett 27 (7): 1100–1105.
Vancouver
1.
Dao TH, Decuyper L, Mollet K, Kenis S, De Kimpe N, Van Nguyen T, et al. Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks. SYNLETT. 2016;27(7):1100–5.
IEEE
[1]
T. H. Dao et al., “Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks,” SYNLETT, vol. 27, no. 7, pp. 1100–1105, 2016.
@article{7063602,
  abstract     = {This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, and 1,3-oxazinan-2-ones. This -lactam building block approach provides a convenient new entry into trifluoromethylated scaffolds as useful synthetic intermediates en route to a variety of CF3-functionalized target structures.},
  author       = {Dao, Thi Hang and Decuyper, Lena and Mollet, Karen and Kenis, Sara and De Kimpe, Norbert and Van Nguyen, Tuyen and D'hooghe, Matthias},
  issn         = {0936-5214},
  journal      = {SYNLETT},
  keywords     = {beta-lactams,azetidines,aminopropanes,oxazinanes,fluorine,CF3,:BETA-AMINO-ACID,STEREOSELECTIVE-SYNTHESIS,STRAIGHTFORWARD SYNTHESIS,RING TRANSFORMATION,STAUDINGER REACTION,CONTINUOUS-FLOW,HETEROCYCLES,INHIBITORS,PROTEASE,2-AZETIDINONES},
  language     = {eng},
  number       = {7},
  pages        = {1100--1105},
  title        = {Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks},
  url          = {http://dx.doi.org/10.1055/s-0035-1561316},
  volume       = {27},
  year         = {2016},
}

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