Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain
- Author
- Ivan Trus (UGent) , Ilias Frydas (UGent) , Vishwanatha Reddy Avalakuppa Papi Reddy (UGent) , Caroline Bonckaert, Yewei Li (UGent) , Lise Kvisgaard, Lars Larsen and Hans Nauwynck (UGent)
- Organization
- Project
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- PORRSCON (New Tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia)
- Abstract
- Stable spatial distribution of porcine reproductive and respiratory syndrome (PRRSV)-1 subtypes in Europe is accompanied by a strong population immunity induced by local PRRSV strains. In the present study, it was examined if the immunity induced by three West European subtype 1 PRRSV strains (2007 isolate 07V063 and 2013 isolates 13V091 and 13V117) offers protection against the highly virulent East European subtype 3 PRRSV strain Lena. The number of fever days was greater (p < 0.05) in the control group (7.6 +/- 1.7 days) compared to the immune groups (07V063-immune: 4.0 +/- 1.2 days, 13V091-immune: 4.6 +/- 1.1 days, 13V117-immune: 4.0 +/- 2.9 days). In all groups, protection was characterized by reduction (p < 0.05) of AUC values of nasal shedding (control: 14.6, 07V063-immune: 3.4, 13V091-immune: 8.9, 13V117-immune: 8.0) and viremia (control: 28.1, 07V063-immune: 5.4, 13V091-immune: 9.0, 13V117-immune: 8.3). Reduction of respiratory disease, nasal shedding (mean AUC and mean peak values) and viremia (mean AUC and mean peak values) was more pronounced in 07V063-immune (p < 0.05) than in 13V091-immune and 13V117-immune animals. Inoculation with subtype 1 PRRSV strains caused priming of the Lena-specific virus neutralization antibody response. Upon challenge with Lena, we observed a very strong serological booster effect for neutralizing antibodies against strains used for the first inoculation. Our results indicate that inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level elicited by recently isolated subtype 1 PRRSV strains may impair the outcome of the spatial expansion of subtype 3 strains from East Europe to West Europe.
- Keywords
- RESPIRATORY SYNDROME VIRUS, CLUSTER, NEUTRALIZING ANTIBODIES, PIGS, CHALLENGE, VACCINE, Adaptive immunity, PRRS, PRRSV, Subtype, Spatial distribution, Lena, Viremia, Virus shedding, Cross-protection
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-7053533
- MLA
- Trus, Ivan, et al. “Immunity Raised by Recent European Subtype 1 PRRSV Strains Allows Better Replication of East European Subtype 3 PRRSV Strain Lena than That Raised by an Older Strain.” VETERINARY RESEARCH, vol. 47, 2016, doi:10.1186/s13567-015-0292-y.
- APA
- Trus, I., Frydas, I., Avalakuppa Papi Reddy, V. R., Bonckaert, C., Li, Y., Kvisgaard, L., … Nauwynck, H. (2016). Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain. VETERINARY RESEARCH, 47. https://doi.org/10.1186/s13567-015-0292-y
- Chicago author-date
- Trus, Ivan, Ilias Frydas, Vishwanatha Reddy Avalakuppa Papi Reddy, Caroline Bonckaert, Yewei Li, Lise Kvisgaard, Lars Larsen, and Hans Nauwynck. 2016. “Immunity Raised by Recent European Subtype 1 PRRSV Strains Allows Better Replication of East European Subtype 3 PRRSV Strain Lena than That Raised by an Older Strain.” VETERINARY RESEARCH 47. https://doi.org/10.1186/s13567-015-0292-y.
- Chicago author-date (all authors)
- Trus, Ivan, Ilias Frydas, Vishwanatha Reddy Avalakuppa Papi Reddy, Caroline Bonckaert, Yewei Li, Lise Kvisgaard, Lars Larsen, and Hans Nauwynck. 2016. “Immunity Raised by Recent European Subtype 1 PRRSV Strains Allows Better Replication of East European Subtype 3 PRRSV Strain Lena than That Raised by an Older Strain.” VETERINARY RESEARCH 47. doi:10.1186/s13567-015-0292-y.
- Vancouver
- 1.Trus I, Frydas I, Avalakuppa Papi Reddy VR, Bonckaert C, Li Y, Kvisgaard L, et al. Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain. VETERINARY RESEARCH. 2016;47.
- IEEE
- [1]I. Trus et al., “Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain,” VETERINARY RESEARCH, vol. 47, 2016.
@article{7053533, abstract = {{Stable spatial distribution of porcine reproductive and respiratory syndrome (PRRSV)-1 subtypes in Europe is accompanied by a strong population immunity induced by local PRRSV strains. In the present study, it was examined if the immunity induced by three West European subtype 1 PRRSV strains (2007 isolate 07V063 and 2013 isolates 13V091 and 13V117) offers protection against the highly virulent East European subtype 3 PRRSV strain Lena. The number of fever days was greater (p < 0.05) in the control group (7.6 +/- 1.7 days) compared to the immune groups (07V063-immune: 4.0 +/- 1.2 days, 13V091-immune: 4.6 +/- 1.1 days, 13V117-immune: 4.0 +/- 2.9 days). In all groups, protection was characterized by reduction (p < 0.05) of AUC values of nasal shedding (control: 14.6, 07V063-immune: 3.4, 13V091-immune: 8.9, 13V117-immune: 8.0) and viremia (control: 28.1, 07V063-immune: 5.4, 13V091-immune: 9.0, 13V117-immune: 8.3). Reduction of respiratory disease, nasal shedding (mean AUC and mean peak values) and viremia (mean AUC and mean peak values) was more pronounced in 07V063-immune (p < 0.05) than in 13V091-immune and 13V117-immune animals. Inoculation with subtype 1 PRRSV strains caused priming of the Lena-specific virus neutralization antibody response. Upon challenge with Lena, we observed a very strong serological booster effect for neutralizing antibodies against strains used for the first inoculation. Our results indicate that inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level elicited by recently isolated subtype 1 PRRSV strains may impair the outcome of the spatial expansion of subtype 3 strains from East Europe to West Europe.}}, articleno = {{15}}, author = {{Trus, Ivan and Frydas, Ilias and Avalakuppa Papi Reddy, Vishwanatha Reddy and Bonckaert, Caroline and Li, Yewei and Kvisgaard, Lise and Larsen, Lars and Nauwynck, Hans}}, issn = {{0928-4249}}, journal = {{VETERINARY RESEARCH}}, keywords = {{RESPIRATORY SYNDROME VIRUS,CLUSTER,NEUTRALIZING ANTIBODIES,PIGS,CHALLENGE,VACCINE,Adaptive immunity,PRRS,PRRSV,Subtype,Spatial distribution,Lena,Viremia,Virus shedding,Cross-protection}}, language = {{eng}}, pages = {{9}}, title = {{Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain}}, url = {{http://doi.org/10.1186/s13567-015-0292-y}}, volume = {{47}}, year = {{2016}}, }
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