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Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain

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PORRSCON (New tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia)
Abstract
Stable spatial distribution of porcine reproductive and respiratory syndrome (PRRSV)-1 subtypes in Europe is accompanied by a strong population immunity induced by local PRRSV strains. In the present study, it was examined if the immunity induced by three West European subtype 1 PRRSV strains (2007 isolate 07V063 and 2013 isolates 13V091 and 13V117) offers protection against the highly virulent East European subtype 3 PRRSV strain Lena. The number of fever days was greater (p < 0.05) in the control group (7.6 +/- 1.7 days) compared to the immune groups (07V063-immune: 4.0 +/- 1.2 days, 13V091-immune: 4.6 +/- 1.1 days, 13V117-immune: 4.0 +/- 2.9 days). In all groups, protection was characterized by reduction (p < 0.05) of AUC values of nasal shedding (control: 14.6, 07V063-immune: 3.4, 13V091-immune: 8.9, 13V117-immune: 8.0) and viremia (control: 28.1, 07V063-immune: 5.4, 13V091-immune: 9.0, 13V117-immune: 8.3). Reduction of respiratory disease, nasal shedding (mean AUC and mean peak values) and viremia (mean AUC and mean peak values) was more pronounced in 07V063-immune (p < 0.05) than in 13V091-immune and 13V117-immune animals. Inoculation with subtype 1 PRRSV strains caused priming of the Lena-specific virus neutralization antibody response. Upon challenge with Lena, we observed a very strong serological booster effect for neutralizing antibodies against strains used for the first inoculation. Our results indicate that inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level elicited by recently isolated subtype 1 PRRSV strains may impair the outcome of the spatial expansion of subtype 3 strains from East Europe to West Europe.
Keywords
RESPIRATORY SYNDROME VIRUS, CLUSTER, NEUTRALIZING ANTIBODIES, PIGS, CHALLENGE, VACCINE, Adaptive immunity, PRRS, PRRSV, Subtype, Spatial distribution, Lena, Viremia, Virus shedding, Cross-protection

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Citation

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Chicago
Trus, Ivan, Ilias Frydas, Vishwanatha Reddy Avalakuppa Papi Reddy, Caroline Bonckaert, Yewei Li, Lise Kvisgaard, Lars Larsen, and Hans Nauwynck. 2016. “Immunity Raised by Recent European Subtype 1 PRRSV Strains Allows Better Replication of East European Subtype 3 PRRSV Strain Lena Than That Raised by an Older Strain.” Veterinary Research 47.
APA
Trus, I., Frydas, I., Avalakuppa Papi Reddy, V. R., Bonckaert, C., Li, Y., Kvisgaard, L., Larsen, L., et al. (2016). Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain. VETERINARY RESEARCH, 47.
Vancouver
1.
Trus I, Frydas I, Avalakuppa Papi Reddy VR, Bonckaert C, Li Y, Kvisgaard L, et al. Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain. VETERINARY RESEARCH. 2016;47.
MLA
Trus, Ivan, Ilias Frydas, Vishwanatha Reddy Avalakuppa Papi Reddy, et al. “Immunity Raised by Recent European Subtype 1 PRRSV Strains Allows Better Replication of East European Subtype 3 PRRSV Strain Lena Than That Raised by an Older Strain.” VETERINARY RESEARCH 47 (2016): n. pag. Print.
@article{7053533,
  abstract     = {Stable spatial distribution of porcine reproductive and respiratory syndrome (PRRSV)-1 subtypes in Europe is accompanied by a strong population immunity induced by local PRRSV strains. In the present study, it was examined if the immunity induced by three West European subtype 1 PRRSV strains (2007 isolate 07V063 and 2013 isolates 13V091 and 13V117) offers protection against the highly virulent East European subtype 3 PRRSV strain Lena. The number of fever days was greater (p {\textlangle} 0.05) in the control group (7.6 +/- 1.7 days) compared to the immune groups (07V063-immune: 4.0 +/- 1.2 days, 13V091-immune: 4.6 +/- 1.1 days, 13V117-immune: 4.0 +/- 2.9 days). In all groups, protection was characterized by reduction (p {\textlangle} 0.05) of AUC values of nasal shedding (control: 14.6, 07V063-immune: 3.4, 13V091-immune: 8.9, 13V117-immune: 8.0) and viremia (control: 28.1, 07V063-immune: 5.4, 13V091-immune: 9.0, 13V117-immune: 8.3). Reduction of respiratory disease, nasal shedding (mean AUC and mean peak values) and viremia (mean AUC and mean peak values) was more pronounced in 07V063-immune (p {\textlangle} 0.05) than in 13V091-immune and 13V117-immune animals. Inoculation with subtype 1 PRRSV strains caused priming of the Lena-specific virus neutralization antibody response. Upon challenge with Lena, we observed a very strong serological booster effect for neutralizing antibodies against strains used for the first inoculation. Our results indicate that inoculation with subtype 1 PRRSV strains can partially protect against antigenically divergent subtype 3 strains. The lower protection level elicited by recently isolated subtype 1 PRRSV strains may impair the outcome of the spatial expansion of subtype 3 strains from East Europe to West Europe.},
  articleno    = {15},
  author       = {Trus, Ivan and Frydas, Ilias and Avalakuppa Papi Reddy, Vishwanatha Reddy and Bonckaert, Caroline and Li, Yewei and Kvisgaard, Lise and Larsen, Lars and Nauwynck, Hans},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  language     = {eng},
  pages        = {9},
  title        = {Immunity raised by recent European subtype 1 PRRSV strains allows better replication of East European subtype 3 PRRSV strain Lena than that raised by an older strain},
  url          = {http://dx.doi.org/10.1186/s13567-015-0292-y},
  volume       = {47},
  year         = {2016},
}

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