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Maternal age at childbirth is associated with glucose metabolism in adult men

Charlotte Verroken UGent, Jean Kaufman UGent, Stefan Goemaere, Kaatje Toye UGent and Bruno Lapauw UGent (2015) ENDOCRINE REVIEWS. 36(2, suppl.).
abstract
BACKGROUND: Although maternal age at childbirth tends to increase worldwide, studies investigating the effects of this trend on metabolic health in the offspring are scarce. OBJECTIVE: We aimed to determine whether maternal age at childbirth is associated with adult body composition and parameters reflecting metabolic health in a cohort of young, healthy men. METHODS: This study is part of a population-based sibling pair study in healthy men aged 25 to 45 years old. 689 subjects (mean age 33.9 +/- 5.4 years) for whom maternal data were available were included in the present analyses. Data collected in the study included birth weight, adult weight, height, DXA-derived body composition and blood pressure. Total cholesterol, glucose and insulin levels were determined in fasting serum samples. Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). Cross-sectional associations were investigated using linear mixed-effects modeling. RESULTS: Maternal age at childbirth was 27.0 ± 4.7 years (range 15-48) and was positively associated with birth weight (β=0.13; p=0.001). In their adult sons, maternal age at childbirth was inversely associated with fasting glucose levels (β=-0.12; p=0.001) and HOMA-IR values (β=-0.07; p=0.050) after adjustment for adult age and BMI. After further adjustment for birth weight, the associations between maternal age and glucose levels remained significant (β=-0.12; p=0.003), whereas the association between maternal age and HOMA-IR weakened (p=0.092) and birth weight became an independent inverse predictor of HOMA-IR (β=-0.07; p=0.039). No associations were found between maternal age and body composition, blood pressure or cholesterol levels. When subjects were divided into 4 groups according to maternal age at birth (<25, 25-29, 30-34 and ≥35 years), sons of mothers aged 30 to 34 at childbirth had significantly lower HOMA-IR values and fasting insulin levels compared to sons of mothers in the other age groups (p=0.007-0.015 for HOMA-IR, p=0.007-0.028 for insulin), whereas sons of mothers aged <25 had higher fasting glucose levels compared to sons of mothers aged 30-34 (p=0.010) and sons of mothers aged ≥35 (p=0.042). These associations were independent of adult age, BMI and birth weight. CONCLUSION: Maternal age at childbirth is associated with birth weight and glucose metabolism in adulthood. Part of the association between maternal age and insulin resistance might be mediated through birth weight.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
in
ENDOCRINE REVIEWS
Endocr. Rev.
volume
36
issue
2, suppl.
conference name
97th Annual meeting of the Endocrine Society (ENDO 2015)
conference location
San Diego, CA, USA
conference start
2015-06-19
conference end
2015-06-22
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
14.898 (2015)
JCR rank
4/131 (2015)
JCR quartile
1 (2015)
ISSN
0163-769X
language
English
UGent publication?
yes
classification
C3
id
7052240
handle
http://hdl.handle.net/1854/LU-7052240
date created
2016-01-26 09:25:36
date last changed
2016-12-19 15:37:10
@inproceedings{7052240,
  abstract     = {BACKGROUND: Although maternal age at childbirth tends to increase worldwide, studies investigating the effects of this trend on metabolic health in the offspring are scarce.
OBJECTIVE: We aimed to determine whether maternal age at childbirth is associated with adult body composition and parameters reflecting metabolic health in a cohort of young, healthy men.
METHODS: This study is part of a population-based sibling pair study in healthy men aged 25 to 45 years old. 689 subjects (mean age 33.9 +/- 5.4 years) for whom maternal data were available were included in the present analyses. Data collected in the study included birth weight, adult weight, height, DXA-derived body composition and blood pressure. Total cholesterol, glucose and insulin levels were determined in fasting serum samples. Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). Cross-sectional associations were investigated using linear mixed-effects modeling.
RESULTS: Maternal age at childbirth was 27.0 {\textpm} 4.7 years (range 15-48) and was positively associated with birth weight (\ensuremath{\beta}=0.13; p=0.001). In their adult sons, maternal age at childbirth was inversely associated with fasting glucose levels (\ensuremath{\beta}=-0.12; p=0.001) and HOMA-IR values (\ensuremath{\beta}=-0.07; p=0.050) after adjustment for adult age and BMI. After further adjustment for birth weight, the associations between maternal age and glucose levels remained significant (\ensuremath{\beta}=-0.12; p=0.003), whereas the association between maternal age and HOMA-IR weakened (p=0.092) and birth weight became an independent inverse predictor of HOMA-IR (\ensuremath{\beta}=-0.07; p=0.039). No associations were found between maternal age and body composition, blood pressure or cholesterol levels.
When subjects were divided into 4 groups according to maternal age at birth ({\textlangle}25, 25-29, 30-34 and \ensuremath{\geq}35 years), sons of mothers aged 30 to 34 at childbirth had significantly lower HOMA-IR values and fasting insulin levels compared to sons of mothers in the other age groups (p=0.007-0.015 for HOMA-IR, p=0.007-0.028 for insulin), whereas sons of mothers aged {\textlangle}25 had higher fasting glucose levels compared to sons of mothers aged 30-34 (p=0.010) and sons of mothers aged \ensuremath{\geq}35 (p=0.042). These associations were independent of adult age, BMI and birth weight. 
CONCLUSION: Maternal age at childbirth is associated with birth weight and glucose metabolism in adulthood. Part of the association between maternal age and insulin resistance might be mediated through birth weight.},
  author       = {Verroken, Charlotte and Kaufman, Jean and Goemaere, Stefan and Toye, Kaatje and Lapauw, Bruno},
  booktitle    = {ENDOCRINE REVIEWS},
  issn         = {0163-769X},
  language     = {eng},
  location     = {San Diego, CA, USA},
  number       = {2, suppl.},
  title        = {Maternal age at childbirth is associated with glucose metabolism in adult men},
  volume       = {36},
  year         = {2015},
}

Chicago
Verroken, Charlotte, Jean Kaufman, Stefan Goemaere, Kaatje Toye, and Bruno Lapauw. 2015. “Maternal Age at Childbirth Is Associated with Glucose Metabolism in Adult Men.” In Endocrine Reviews. Vol. 36.
APA
Verroken, C., Kaufman, J., Goemaere, S., Toye, K., & Lapauw, B. (2015). Maternal age at childbirth is associated with glucose metabolism in adult men. ENDOCRINE REVIEWS (Vol. 36). Presented at the 97th Annual meeting of the Endocrine Society (ENDO 2015).
Vancouver
1.
Verroken C, Kaufman J, Goemaere S, Toye K, Lapauw B. Maternal age at childbirth is associated with glucose metabolism in adult men. ENDOCRINE REVIEWS. 2015.
MLA
Verroken, Charlotte, Jean Kaufman, Stefan Goemaere, et al. “Maternal Age at Childbirth Is Associated with Glucose Metabolism in Adult Men.” Endocrine Reviews. Vol. 36. 2015. Print.