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Synthesis of new cyclic and acyclic biologically relevant amino acid derivatives

(2016)
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Abstract
The discovery of non-proteinogenic amino acids among natural products has significantly increased interest in this class of compounds as they may possess interesting biological activity and could also serve as valuable building blocks in the synthesis of new classes of bioactive compounds as well as for the synthesis and design of peptides. Some natural non-proteinogenic amino acids were proposed as neurotoxic compounds which play a role in neurodegenerative diseases. The misincorporation of some non-proteinogenic amino acids into proteins in place of canonical amino acids causes toxic effect and has been implicated in the pathophysiology of a wide range of diseases, including amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. In that respect, the synthesis of new derivatives of non-proteinogenic α- and β-amino acids, including acyclic and cyclic scaffolds, was the subject of the present research.
Keywords
Azetidines, Aziridines, Piperidines, Non-proteinogenic amino acids, Diversity oriented synthesis, Epoxides

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Citation

Please use this url to cite or link to this publication:

Chicago
Semina, Elena. 2016. “Synthesis of New Cyclic and Acyclic Biologically Relevant Amino Acid Derivatives”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Semina, E. (2016). Synthesis of new cyclic and acyclic biologically relevant amino acid derivatives. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Semina E. Synthesis of new cyclic and acyclic biologically relevant amino acid derivatives. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2016.
MLA
Semina, Elena. “Synthesis of New Cyclic and Acyclic Biologically Relevant Amino Acid Derivatives.” 2016 : n. pag. Print.
@phdthesis{7041917,
  abstract     = {The discovery of non-proteinogenic amino acids among natural products has significantly increased interest in this class of compounds as they may possess interesting biological activity and could also serve as valuable building blocks in the synthesis of new classes of bioactive compounds as well as for the synthesis and design of peptides. Some natural non-proteinogenic amino acids were proposed as neurotoxic compounds which play a role in neurodegenerative diseases. The misincorporation of some non-proteinogenic amino acids into proteins in place of canonical amino acids causes toxic effect and has been implicated in the pathophysiology of a wide range of diseases, including amyotrophic lateral sclerosis (ALS) and Alzheimer{\textquoteright}s disease. In that respect, the synthesis of new derivatives of non-proteinogenic \ensuremath{\alpha}- and \ensuremath{\beta}-amino acids, including acyclic and cyclic scaffolds, was the subject of the present research.},
  author       = {Semina, Elena},
  isbn         = {9789059898561},
  keyword      = {Azetidines,Aziridines,Piperidines,Non-proteinogenic amino acids,Diversity oriented synthesis,Epoxides},
  language     = {eng},
  pages        = {VI, 196},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Synthesis of new cyclic and acyclic biologically relevant amino acid derivatives},
  year         = {2016},
}