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Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use

(2015) INTERNATIONAL JOURNAL OF CANCER. 137(4). p.868-877
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Abstract
Several gene expression-based prognostic signatures have been described in neuroblastoma, but none have successfully been applied in the clinic. Here we have developed a clinically applicable prognostic gene signature, both with regards to number of genes and analysis platform. Importantly, it does not require comparison between patients and is applicable amongst high-risk patients. The signature is based on a two-gene score (R-score) with prognostic power in high-stage tumours (stage 4 and/or MYCN-amplified diagnosed after 18 months of age). QPCR-based and array-based analyses of matched cDNAs confirmed cross platform (array-qPCR) transferability. We also defined a fixed cut-off value identifying prognostically differing subsets of high-risk patients on an individual patient basis. This gene expression signature independently contributes to the current neuroblastoma classification system, and if prospectively validated could provide further stratification of high-risk patients, and potential upfront identification of a group of patients that are in need of new/additional treatment regimens.
Keywords
OVEREXPRESSION, STAGE, AMPLIFICATION, GENES, CANCER, CELL LINES, R-score, EXPRESSION-BASED CLASSIFICATION, METASTATIC NEUROBLASTOMA, MULTIGENE SIGNATURE, GOOD PROGNOSIS, high-risk, prognosis, neuroblastoma

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Citation

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Chicago
von Stedingk, Kristoffer, Katleen De Preter, Jo Vandesompele, Rosa Noguera, Ingrid Øra, Jan Koster, Rogier Versteeg, Sven Påhlman, David Lindgren, and Håkan Axelson. 2015. “Individual Patient Risk Stratification of High-risk Neuroblastomas Using a Two-gene Score Suited for Clinical Use.” International Journal of Cancer 137 (4): 868–877.
APA
von Stedingk, K., De Preter, K., Vandesompele, J., Noguera, R., Øra, I., Koster, J., Versteeg, R., et al. (2015). Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use. INTERNATIONAL JOURNAL OF CANCER, 137(4), 868–877.
Vancouver
1.
von Stedingk K, De Preter K, Vandesompele J, Noguera R, Øra I, Koster J, et al. Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use. INTERNATIONAL JOURNAL OF CANCER. 2015;137(4):868–77.
MLA
von Stedingk, Kristoffer et al. “Individual Patient Risk Stratification of High-risk Neuroblastomas Using a Two-gene Score Suited for Clinical Use.” INTERNATIONAL JOURNAL OF CANCER 137.4 (2015): 868–877. Print.
@article{7040581,
  abstract     = {Several gene expression-based prognostic signatures have been described in neuroblastoma, but none have successfully been applied in the clinic. Here we have developed a clinically applicable prognostic gene signature, both with regards to number of genes and analysis platform. Importantly, it does not require comparison between patients and is applicable amongst high-risk patients. The signature is based on a two-gene score (R-score) with prognostic power in high-stage tumours (stage 4 and/or MYCN-amplified diagnosed after 18 months of age). QPCR-based and array-based analyses of matched cDNAs confirmed cross platform (array-qPCR) transferability. We also defined a fixed cut-off value identifying prognostically differing subsets of high-risk patients on an individual patient basis. This gene expression signature independently contributes to the current neuroblastoma classification system, and if prospectively validated could provide further stratification of high-risk patients, and potential upfront identification of a group of patients that are in need of new/additional treatment regimens.},
  author       = {von Stedingk, Kristoffer and De Preter, Katleen and Vandesompele, Jo and Noguera, Rosa and Øra, Ingrid and Koster, Jan and Versteeg, Rogier and Påhlman, Sven and Lindgren, David and Axelson, Håkan},
  issn         = {0020-7136},
  journal      = {INTERNATIONAL JOURNAL OF CANCER},
  keywords     = {OVEREXPRESSION,STAGE,AMPLIFICATION,GENES,CANCER,CELL LINES,R-score,EXPRESSION-BASED CLASSIFICATION,METASTATIC NEUROBLASTOMA,MULTIGENE SIGNATURE,GOOD PROGNOSIS,high-risk,prognosis,neuroblastoma},
  language     = {eng},
  number       = {4},
  pages        = {868--877},
  title        = {Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use},
  url          = {http://dx.doi.org/10.1002/ijc.29461},
  volume       = {137},
  year         = {2015},
}

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