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Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody

(2016) JOURNAL OF VIROLOGY. 90(1). p.611-615
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Abstract
We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal beta-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
Keywords
SITE, HIV-1, ECTODOMAIN, COMPLEX, M2 PROTEIN, PEPTIDE ANTIGEN, HUMAN RHINOVIRUS, NEUTRALIZING ANTIBODY, MONOCLONAL-ANTIBODY, EPITOPE

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Citation

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Chicago
Cho, Ki Joon, Bert Schepens, Kristof Moonens, Lei Deng, Walter Fiers, Han Remaut, and Xavier Saelens. 2016. “Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.” Journal of Virology 90 (1): 611–615.
APA
Cho, K. J., Schepens, B., Moonens, K., Deng, L., Fiers, W., Remaut, H., & Saelens, X. (2016). Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody. JOURNAL OF VIROLOGY, 90(1), 611–615.
Vancouver
1.
Cho KJ, Schepens B, Moonens K, Deng L, Fiers W, Remaut H, et al. Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody. JOURNAL OF VIROLOGY. 2016;90(1):611–5.
MLA
Cho, Ki Joon, Bert Schepens, Kristof Moonens, et al. “Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.” JOURNAL OF VIROLOGY 90.1 (2016): 611–615. Print.
@article{7039165,
  abstract     = {We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal beta-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.},
  author       = {Cho, Ki Joon and Schepens, Bert and Moonens, Kristof and Deng, Lei and Fiers, Walter and Remaut, Han and Saelens, Xavier},
  issn         = {0022-538X},
  journal      = {JOURNAL OF VIROLOGY},
  language     = {eng},
  number       = {1},
  pages        = {611--615},
  title        = {Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody},
  url          = {http://dx.doi.org/10.1128/JVI.02105-15},
  volume       = {90},
  year         = {2016},
}

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