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Abstract
The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall mmunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other mmunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Keywords
immunogenicity, immunotherapy, anti-tumor immunity, molecular dicine, oncoimmunology, patient prognosis, translational medicine, HUMAN TUMOR-CELLS, HIGH HYDROSTATIC-PRESSURE, APOPTOTIC CALRETICULIN EXPOSURE, ANTICANCER IMMUNE-RESPONSES, ACTIVATING POLYPEPTIDE-II, FORMYL PEPTIDE RECEPTORS, RIBOSOMAL-PROTEIN DIMER, CYTOTOXIC T-LYMPHOCYTES, NEGATIVE BREAST-CANCER, PHOTODYNAMIC THERAPY

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Citation

Please use this url to cite or link to this publication:

Chicago
Garg, Abhishek D, Lorenzo Galluzzi, Lionel Apetoh, Thais Baert, Raymond B Birge, José Manuel Bravo-San Pedro, Karine Breckpot, et al. 2015. “Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.” Frontiers in Immunology 6.
APA
Garg, Abhishek D, Galluzzi, L., Apetoh, L., Baert, T., Birge, R. B., Bravo-San Pedro, J. M., Breckpot, K., et al. (2015). Molecular and translational classifications of DAMPs in immunogenic cell death. FRONTIERS IN IMMUNOLOGY, 6.
Vancouver
1.
Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, et al. Molecular and translational classifications of DAMPs in immunogenic cell death. FRONTIERS IN IMMUNOLOGY. 2015;6.
MLA
Garg, Abhishek D, Lorenzo Galluzzi, Lionel Apetoh, et al. “Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.” FRONTIERS IN IMMUNOLOGY 6 (2015): n. pag. Print.
@article{7039085,
  abstract     = {The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall mmunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called {\textacutedbl}damage-associated molecular patterns{\textacutedbl} (DAMPs). The emission of DAMPs and other mmunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.},
  articleno    = {588},
  author       = {Garg, Abhishek D and Galluzzi, Lorenzo and Apetoh, Lionel and Baert, Thais and Birge, Raymond B and Bravo-San Pedro, Jos{\'e} Manuel and Breckpot, Karine and Brough, David and Chaurio, Ricardo and Cirone, Mara and Coosemans, An and Coulie, Pierre G and De Ruysscher, Dirk and Dini, Luciana and de Witte, Peter and Dudek-Peric, Aleksandra M and Faggioni, Alberto and Fucikova, Jitka and Gaipl, Udo S and Golab, Jakub and Gougeon, Marie-Lise and Hamblin, Michael R and Hemminki, Akseli and Herrmann, Martin and Hodge, James W and Kepp, Oliver and Kroemer, Guido and Krysko, Dmitri and Land, Walter G and Madeo, Frank and Manfredi, Angelo A and Mattarollo, Stephen R and Maueroder, Christian and Merendino, Nicol{\`o} and Multhoff, Gabriele and Pabst, Thomas and Ricci, Jean-Ehrland and Riganti, Chiara and Romano, Erminia and Rufo, Nicole and Smyth, Mark J and Sonnemann, J{\"u}rgen and Spisek, Radek and Stagg, John and Vacchelli, Erika and Vandenabeele, Peter and Vandenberk, Lien and Van den Eynde, Benoit J and Van Gool, Stefaan and Velotti, Francesca and Zitvogel, Laurence and Agostinis, Patrizia},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keyword      = {immunogenicity,immunotherapy,anti-tumor immunity,molecular dicine,oncoimmunology,patient prognosis,translational medicine,HUMAN TUMOR-CELLS,HIGH HYDROSTATIC-PRESSURE,APOPTOTIC CALRETICULIN EXPOSURE,ANTICANCER IMMUNE-RESPONSES,ACTIVATING POLYPEPTIDE-II,FORMYL PEPTIDE RECEPTORS,RIBOSOMAL-PROTEIN DIMER,CYTOTOXIC T-LYMPHOCYTES,NEGATIVE BREAST-CANCER,PHOTODYNAMIC THERAPY},
  language     = {eng},
  pages        = {24},
  title        = {Molecular and translational classifications of DAMPs in immunogenic cell death},
  url          = {http://dx.doi.org/10.3389/fimmu.2015.00588},
  volume       = {6},
  year         = {2015},
}

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