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Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange

Charlotte Sarre, Ana González Hernández UGent, Stefanie Van Coppernolle UGent, Grietje Grit, Korneel Grauwet, Frederik Van Meulder UGent, Koen Chiers UGent, Wim Van Den Broeck UGent, Peter Geldhof UGent and Edwin Claerebout UGent (2015) VETERINARY RESEARCH. 46.
abstract
The sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high susceptibility remain unknown. Different immune responses could be a potential cause; thus in this study, the cutaneous immune response and in vitro cellular immune response after antigen re-stimulation were examined in naturally infested BB. Cytokine production in the skin and in circulating re-stimulated peripheral blood mononuclear cells (PBMC) demonstrated a mixed pro-inflammatory Th2/Th17 profile, with transcription of IL-4, IL-13, IL-6 and IL-17. Strong IL-17 up-regulation in the skin of BB was associated with an influx of eosinophils and other immune cells, potentially leading towards more severe symptoms. Virtually no changes in cutaneous IFN-gamma transcription were detected, while there was substantial IFN-gamma up-regulation in re-stimulated PBMC from infested and uninfested animals, potentially indicating a role of this pro-inflammatory cytokine in the innate immune response. In Holstein-Friesian (HF) cattle, generally more resistant to P.ovis infection, a largely similar immunologic response was observed. Differences between HF and BB were the lack of cutaneous IL-17 response in infested HF and low transcription levels of IFN-gamma and high IL-10 transcription in re-stimulated PBMC from both infested and uninfested animals. Further research is needed to identify potential cell sources and biological functions for these cytokines and to fully unravel the basis of this different breed susceptibility to P. ovis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CALVES, RESISTANCE, PATHOGENESIS, IMMUNOLOGY, INDUCTION, INFESTATION, DENDRITIC CELLS, STANCHIONED CATTLE, SARCOPTES-SCABIEI, SHEEP SCAB MITE
journal title
VETERINARY RESEARCH
Vet. Res.
volume
46
article number
131
pages
10 pages
Web of Science type
Article
Web of Science id
000364906300001
JCR category
VETERINARY SCIENCES
JCR impact factor
2.928 (2015)
JCR rank
3/138 (2015)
JCR quartile
1 (2015)
ISSN
0928-4249
DOI
10.1186/s13567-015-0277-x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7037658
handle
http://hdl.handle.net/1854/LU-7037658
date created
2016-01-14 12:53:12
date last changed
2016-12-21 15:42:31
@article{7037658,
  abstract     = {The sheep scab mite, Psoroptes ovis, is a major problem in the beef cattle industry, especially in Belgian Blue (BB) cattle. This breed is naturally more predisposed to psoroptic mange but reasons for this high susceptibility remain unknown. Different immune responses could be a potential cause; thus in this study, the cutaneous immune response and in vitro cellular immune response after antigen re-stimulation were examined in naturally infested BB. Cytokine production in the skin and in circulating re-stimulated peripheral blood mononuclear cells (PBMC) demonstrated a mixed pro-inflammatory Th2/Th17 profile, with transcription of IL-4, IL-13, IL-6 and IL-17. Strong IL-17 up-regulation in the skin of BB was associated with an influx of eosinophils and other immune cells, potentially leading towards more severe symptoms. Virtually no changes in cutaneous IFN-gamma transcription were detected, while there was substantial IFN-gamma up-regulation in re-stimulated PBMC from infested and uninfested animals, potentially indicating a role of this pro-inflammatory cytokine in the innate immune response. In Holstein-Friesian (HF) cattle, generally more resistant to P.ovis infection, a largely similar immunologic response was observed. Differences between HF and BB were the lack of cutaneous IL-17 response in infested HF and low transcription levels of IFN-gamma and high IL-10 transcription in re-stimulated PBMC from both infested and uninfested animals. Further research is needed to identify potential cell sources and biological functions for these cytokines and to fully unravel the basis of this different breed susceptibility to P. ovis.},
  articleno    = {131},
  author       = {Sarre, Charlotte and Gonz{\'a}lez Hern{\'a}ndez, Ana and Van Coppernolle, Stefanie and Grit, Grietje and Grauwet, Korneel and Van Meulder, Frederik and Chiers, Koen and Van Den Broeck, Wim and Geldhof, Peter and Claerebout, Edwin},
  issn         = {0928-4249},
  journal      = {VETERINARY RESEARCH},
  keyword      = {CALVES,RESISTANCE,PATHOGENESIS,IMMUNOLOGY,INDUCTION,INFESTATION,DENDRITIC CELLS,STANCHIONED CATTLE,SARCOPTES-SCABIEI,SHEEP SCAB MITE},
  language     = {eng},
  pages        = {10},
  title        = {Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange},
  url          = {http://dx.doi.org/10.1186/s13567-015-0277-x},
  volume       = {46},
  year         = {2015},
}

Chicago
Sarre, Charlotte, Ana González Hernández, Stefanie Van Coppernolle, Grietje Grit, Korneel Grauwet, Frederik Van Meulder, Koen Chiers, Wim Van Den Broeck, Peter Geldhof, and Edwin Claerebout. 2015. “Comparative Immune Responses Against Psoroptes Ovis in Two Cattle Breeds with Different Susceptibility to Mange.” Veterinary Research 46.
APA
Sarre, C., González Hernández, A., Van Coppernolle, S., Grit, G., Grauwet, K., Van Meulder, F., Chiers, K., et al. (2015). Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange. VETERINARY RESEARCH, 46.
Vancouver
1.
Sarre C, González Hernández A, Van Coppernolle S, Grit G, Grauwet K, Van Meulder F, et al. Comparative immune responses against Psoroptes ovis in two cattle breeds with different susceptibility to mange. VETERINARY RESEARCH. 2015;46.
MLA
Sarre, Charlotte, Ana González Hernández, Stefanie Van Coppernolle, et al. “Comparative Immune Responses Against Psoroptes Ovis in Two Cattle Breeds with Different Susceptibility to Mange.” VETERINARY RESEARCH 46 (2015): n. pag. Print.