Ghent University Academic Bibliography

Advanced

Cytokinin response factors regulate PIN-FORMED auxin transporters

Mária Braun Šimášková UGent, Jose Antonio O'Brien, Mamoona Khan, Giel Van Noorden UGent, Krisztina Otvos, Anne Vieten, Inge De Clercq UGent, Johanna Maria Adriana Van Haperen, Candela Cuesta, Klára Hoyerová, et al. (2015) NATURE COMMUNICATIONS. 6.
abstract
Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SYSTEM, EXPRESSION, REVERSE GENETICS, SIGNAL-TRANSDUCTION, EFFLUX, PLANT ORGANOGENESIS, CELL-DIFFERENTIATION, ARABIDOPSIS-THALIANA, TRANSCRIPTION FACTORS, ROOT-MERISTEM
journal title
NATURE COMMUNICATIONS
Nat. Commun.
volume
6
article number
8717
pages
11 pages
Web of Science type
Article
Web of Science id
000366289800001
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
11.329 (2015)
JCR rank
3/63 (2015)
JCR quartile
1 (2015)
ISSN
2041-1723
DOI
10.1038/ncomms9717
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
7035328
handle
http://hdl.handle.net/1854/LU-7035328
date created
2016-01-12 15:12:29
date last changed
2017-05-04 14:00:55
@article{7035328,
  abstract     = {Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.},
  articleno    = {8717},
  author       = {Braun \v{S}im{\'a}\v{s}kov{\'a}, M{\'a}ria and O'Brien, Jose Antonio and Khan, Mamoona and Van Noorden, Giel and Otvos, Krisztina and Vieten, Anne and De Clercq, Inge and Van Haperen, Johanna Maria Adriana and Cuesta, Candela and Hoyerov{\'a}, Kl{\'a}ra and Vanneste, Steffen and Marhavy, Peter and Wabnik, Krzysztof and Van Breusegem, Frank and Nowack, Moritz and Murphy, Angus and Friml, Jiri and Weijers, Dolf and Beeckman, Tom and Benkova, Eva},
  issn         = {2041-1723},
  journal      = {NATURE COMMUNICATIONS},
  keyword      = {SYSTEM,EXPRESSION,REVERSE GENETICS,SIGNAL-TRANSDUCTION,EFFLUX,PLANT ORGANOGENESIS,CELL-DIFFERENTIATION,ARABIDOPSIS-THALIANA,TRANSCRIPTION FACTORS,ROOT-MERISTEM},
  language     = {eng},
  pages        = {11},
  title        = {Cytokinin response factors regulate PIN-FORMED auxin transporters},
  url          = {http://dx.doi.org/10.1038/ncomms9717},
  volume       = {6},
  year         = {2015},
}

Chicago
Braun Šimášková, Mária, Jose Antonio O’Brien, Mamoona Khan, Giel Van Noorden, Krisztina Otvos, Anne Vieten, Inge De Clercq, et al. 2015. “Cytokinin Response Factors Regulate PIN-FORMED Auxin Transporters.” Nature Communications 6.
APA
Braun Šimášková, M., O’Brien, J. A., Khan, M., Van Noorden, G., Otvos, K., Vieten, A., De Clercq, I., et al. (2015). Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATIONS, 6.
Vancouver
1.
Braun Šimášková M, O’Brien JA, Khan M, Van Noorden G, Otvos K, Vieten A, et al. Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATIONS. 2015;6.
MLA
Braun Šimášková, Mária, Jose Antonio O’Brien, Mamoona Khan, et al. “Cytokinin Response Factors Regulate PIN-FORMED Auxin Transporters.” NATURE COMMUNICATIONS 6 (2015): n. pag. Print.