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Cytokinin response factors regulate PIN-FORMED auxin transporters

Mária Braun Šimášková (UGent) , Jose Antonio O'Brien (UGent) , Mamoona Khan, Giel Van Noorden (UGent) , Krisztina Otvos, Anne Vieten, Inge De Clercq (UGent) , Johanna Maria Adriana Van Haperen, Candela Cuesta, Klára Hoyerová, et al.
(2015) NATURE COMMUNICATIONS. 6.
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Abstract
Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.
Keywords
SYSTEM, EXPRESSION, REVERSE GENETICS, SIGNAL-TRANSDUCTION, EFFLUX, PLANT ORGANOGENESIS, CELL-DIFFERENTIATION, ARABIDOPSIS-THALIANA, TRANSCRIPTION FACTORS, ROOT-MERISTEM

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Citation

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MLA
Braun Šimášková, Mária, et al. “Cytokinin Response Factors Regulate PIN-FORMED Auxin Transporters.” NATURE COMMUNICATIONS, vol. 6, 2015, doi:10.1038/ncomms9717.
APA
Braun Šimášková, M., O’Brien, J. A., Khan, M., Van Noorden, G., Otvos, K., Vieten, A., … Benkova, E. (2015). Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATIONS, 6. https://doi.org/10.1038/ncomms9717
Chicago author-date
Braun Šimášková, Mária, Jose Antonio O’Brien, Mamoona Khan, Giel Van Noorden, Krisztina Otvos, Anne Vieten, Inge De Clercq, et al. 2015. “Cytokinin Response Factors Regulate PIN-FORMED Auxin Transporters.” NATURE COMMUNICATIONS 6. https://doi.org/10.1038/ncomms9717.
Chicago author-date (all authors)
Braun Šimášková, Mária, Jose Antonio O’Brien, Mamoona Khan, Giel Van Noorden, Krisztina Otvos, Anne Vieten, Inge De Clercq, Johanna Maria Adriana Van Haperen, Candela Cuesta, Klára Hoyerová, Steffen Vanneste, Peter Marhavy, Krzysztof Wabnik, Frank Van Breusegem, Moritz Nowack, Angus Murphy, Jiri Friml, Dolf Weijers, Tom Beeckman, and Eva Benkova. 2015. “Cytokinin Response Factors Regulate PIN-FORMED Auxin Transporters.” NATURE COMMUNICATIONS 6. doi:10.1038/ncomms9717.
Vancouver
1.
Braun Šimášková M, O’Brien JA, Khan M, Van Noorden G, Otvos K, Vieten A, et al. Cytokinin response factors regulate PIN-FORMED auxin transporters. NATURE COMMUNICATIONS. 2015;6.
IEEE
[1]
M. Braun Šimášková et al., “Cytokinin response factors regulate PIN-FORMED auxin transporters,” NATURE COMMUNICATIONS, vol. 6, 2015.
@article{7035328,
  abstract     = {{Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.}},
  articleno    = {{8717}},
  author       = {{Braun Šimášková, Mária and O'Brien, Jose Antonio and Khan, Mamoona and Van Noorden, Giel and Otvos, Krisztina and Vieten, Anne and De Clercq, Inge and Van Haperen, Johanna Maria Adriana and Cuesta, Candela and Hoyerová, Klára and Vanneste, Steffen and Marhavy, Peter and Wabnik, Krzysztof and Van Breusegem, Frank and Nowack, Moritz and Murphy, Angus and Friml, Jiri and Weijers, Dolf and Beeckman, Tom and Benkova, Eva}},
  issn         = {{2041-1723}},
  journal      = {{NATURE COMMUNICATIONS}},
  keywords     = {{SYSTEM,EXPRESSION,REVERSE GENETICS,SIGNAL-TRANSDUCTION,EFFLUX,PLANT ORGANOGENESIS,CELL-DIFFERENTIATION,ARABIDOPSIS-THALIANA,TRANSCRIPTION FACTORS,ROOT-MERISTEM}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{Cytokinin response factors regulate PIN-FORMED auxin transporters}},
  url          = {{http://doi.org/10.1038/ncomms9717}},
  volume       = {{6}},
  year         = {{2015}},
}
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