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Desaturase activity is associated with weight status and metabolic risk markers in young children

Maike Wolters, Heike Schlenz, Claudia Börnhorst, Patrizia Risé, Claudio Galli, Luis A Moreno, Valeria Pala, Alfonso Siani, Toomas Veidebaum, Michael Tornaritis, et al. (2015) JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 100(10). p.3760-3769
abstract
Context: Activity of delta-9, delta-6, and delta-5 desaturases (D9D, D6D, D5D) are associated with obesity, insulin resistance, and dyslipidemia. Objective: To investigate the association of estimated desaturase activities with weight status, insulin resistance, and dyslipidemia in children, cross-sectionally and longitudinally. Design: The IDEFICS (Identification and Prevention of Dietary-and Lifestyle-Induced Health Effects in Children and Infants) cohort study was used, with examinations at baseline (T0) and after 2 years (T1). Setting and Participants: Children aged 2 to less than 10 years from eight European countries were recruited in kindergartens/primary schools. Children with available data on fatty acids, outcome, and covariate information were included in the analyses. Methods: Whole blood fatty acids were analyzed in 2600 children at baseline. D9D (16: 1n-7/16: 0), D6D(20: 3n-6/18: 2n-6), andD5D(20: 4n-6/20: 3n-6) activities were estimated from product-precursor fatty acids ratios. Body mass index (BMI), Homeostatic Model Assessment index, and high-density lipoprotein cholesterol (HDL), and triglycerides (TG) served as outcomes for weight status, insulin resistance, and dyslipidemia, respectively. Linear and logistic regression and repeated measures models were used to assess the cross-sectional and longitudinal associations between desaturase activity and outcomes. Results: In the cross-sectional analysis, D9D and D6D were positively associated with BMI and TG z-scores and inversely with HDL z-scores. D5D was inversely associated with BMI and TG z-scores (ie, a D5D increase of 1 unit is associated with a BMI z-score decrease of 0.07 and a 28% lower odds ratio for TG >= 75th percentile). Longitudinally, similar associations were found for T0 desaturase activities with BMI and for T0 D6D with HDL at follow-up (T1). Baseline D6D and D5D were positively associated with the change of HDL z-score from T0 to T1, and D6D with the change of Homeostatic Model Assessment index z-score. Conclusion: Desaturase activities are associated with metabolic risk markers already in young children and appear to predict the metabolic risk.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PLASMA PALMITOLEIC ACID, STEAROYL-COA DESATURASE, MEMBRANE FATTY-ACIDS, INSULIN-RESISTANCE, EUROPEAN CHILDREN, ABDOMINAL ADIPOSITY, CHILDHOOD OBESITY, IDEFICS COHORT, LINOLEIC-ACID, EPIC-POTSDAM
journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
J. Clin. Endocrinol. Metab.
volume
100
issue
10
pages
3760 - 3769
Web of Science type
Article
Web of Science id
000364922600045
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
5.531 (2015)
JCR rank
16/131 (2015)
JCR quartile
1 (2015)
ISSN
0021-972X
DOI
10.1210/jc.2015-2693
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7031613
handle
http://hdl.handle.net/1854/LU-7031613
date created
2016-01-11 09:47:36
date last changed
2016-12-19 15:39:13
@article{7031613,
  abstract     = {Context: Activity of delta-9, delta-6, and delta-5 desaturases (D9D, D6D, D5D) are associated with obesity, insulin resistance, and dyslipidemia. 
Objective: To investigate the association of estimated desaturase activities with weight status, insulin resistance, and dyslipidemia in children, cross-sectionally and longitudinally. 
Design: The IDEFICS (Identification and Prevention of Dietary-and Lifestyle-Induced Health Effects in Children and Infants) cohort study was used, with examinations at baseline (T0) and after 2 years (T1). 
Setting and Participants: Children aged 2 to less than 10 years from eight European countries were recruited in kindergartens/primary schools. Children with available data on fatty acids, outcome, and covariate information were included in the analyses. 
Methods: Whole blood fatty acids were analyzed in 2600 children at baseline. D9D (16: 1n-7/16: 0), D6D(20: 3n-6/18: 2n-6), andD5D(20: 4n-6/20: 3n-6) activities were estimated from product-precursor fatty acids ratios. Body mass index (BMI), Homeostatic Model Assessment index, and high-density lipoprotein cholesterol (HDL), and triglycerides (TG) served as outcomes for weight status, insulin resistance, and dyslipidemia, respectively. Linear and logistic regression and repeated measures models were used to assess the cross-sectional and longitudinal associations between desaturase activity and outcomes. 
Results: In the cross-sectional analysis, D9D and D6D were positively associated with BMI and TG z-scores and inversely with HDL z-scores. D5D was inversely associated with BMI and TG z-scores (ie, a D5D increase of 1 unit is associated with a BMI z-score decrease of 0.07 and a 28\% lower odds ratio for TG {\textrangle}= 75th percentile). Longitudinally, similar associations were found for T0 desaturase activities with BMI and for T0 D6D with HDL at follow-up (T1). Baseline D6D and D5D were positively associated with the change of HDL z-score from T0 to T1, and D6D with the change of Homeostatic Model Assessment index z-score. 
Conclusion: Desaturase activities are associated with metabolic risk markers already in young children and appear to predict the metabolic risk.},
  author       = {Wolters, Maike and Schlenz, Heike and B{\"o}rnhorst, Claudia and Ris{\'e}, Patrizia and Galli, Claudio and Moreno, Luis A and Pala, Valeria and Siani, Alfonso and Veidebaum, Toomas and Tornaritis, Michael and Fraterman, Arno and De Henauw, Stefaan and Marild, Staffan and Molnar, Denes and Ahrens, Wolfgang},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {PLASMA PALMITOLEIC ACID,STEAROYL-COA DESATURASE,MEMBRANE FATTY-ACIDS,INSULIN-RESISTANCE,EUROPEAN CHILDREN,ABDOMINAL ADIPOSITY,CHILDHOOD OBESITY,IDEFICS COHORT,LINOLEIC-ACID,EPIC-POTSDAM},
  language     = {eng},
  number       = {10},
  pages        = {3760--3769},
  title        = {Desaturase activity is associated with weight status and metabolic risk markers in young children},
  url          = {http://dx.doi.org/10.1210/jc.2015-2693},
  volume       = {100},
  year         = {2015},
}

Chicago
Wolters, Maike, Heike Schlenz, Claudia Börnhorst, Patrizia Risé, Claudio Galli, Luis A Moreno, Valeria Pala, et al. 2015. “Desaturase Activity Is Associated with Weight Status and Metabolic Risk Markers in Young Children.” Journal of Clinical Endocrinology & Metabolism 100 (10): 3760–3769.
APA
Wolters, Maike, Schlenz, H., Börnhorst, C., Risé, P., Galli, C., Moreno, L. A., Pala, V., et al. (2015). Desaturase activity is associated with weight status and metabolic risk markers in young children. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 100(10), 3760–3769.
Vancouver
1.
Wolters M, Schlenz H, Börnhorst C, Risé P, Galli C, Moreno LA, et al. Desaturase activity is associated with weight status and metabolic risk markers in young children. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(10):3760–9.
MLA
Wolters, Maike, Heike Schlenz, Claudia Börnhorst, et al. “Desaturase Activity Is Associated with Weight Status and Metabolic Risk Markers in Young Children.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 100.10 (2015): 3760–3769. Print.