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TAS1R3 and UCN2 transcript levels in blood cells are associated with sugary and fatty food consumption in children

T Priego, J Sánchez, C Picó, W Ahrens, Stefaan De Henauw UGent, Y Kourides, L Lissner, D Molnár, LA Moreno, P Russo, et al. (2015) JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 100(9). p.3556-3564
abstract
Context: New types of dietary exposure biomarkers are needed to implement effective strategies for obesity prevention in children. Of special interest are biomarkers of consumption of food rich in simple sugars and fat because their intake has been associated with obesity development. Peripheral blood cells (PBCs) represent a promising new tool for identifying novel, transcript-based biomarkers. Objective: This study aimed to study potential associations between the transcripts of taste receptor type 1 member 3 (TAS1R3) and urocortin II (UCN2) genes in PBCs and the frequency of sugary and fatty food consumption in children. Design, Setting, and Participants: Four hundred sixty-three children from the IDEFICS cohort were selected to include a similar number of boys and girls, both normal-weight and overweight, belonging to eight European countries. Main Outcome Measures: Anthropometric parameters (measured at baseline and in a subset of 193 children after 2 years), food consumption frequency and transcript levels of TAS1R3 and UCN2 genes in PBCs were measured. Results: Children with low-frequency consumption of sugary foods displayed higher TAS1R3 expression levels with respect to those with intermediate or high frequency. In turn, children with high-frequency consumption of fatty foods showed lower UCN2 expression levels with respect to those with low or intermediate frequency. Moreover, transcripts of TAS1R3 were related with body mass index and fat-mass changes after a 2-year follow-up period, with low expression levels of this gene being related with increased fat accumulation overtime. Conclusion: The transcripts of TAS1R3 and UCN2 in PBCs may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FISH-OIL SUPPLEMENTATION, MONONUCLEAR-CELLS, GENE-EXPRESSION PROFILES, WHOLE-BLOOD, INDUCED OBESITY, UROCORTIN 2, IDEFICS, DIET, RISK, IDENTIFICATION
journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
J. Clin. Endocrinol. Metab.
volume
100
issue
9
pages
3556 - 3564
Web of Science type
Article
Web of Science id
000364867800065
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
5.531 (2015)
JCR rank
16/131 (2015)
JCR quartile
1 (2015)
ISSN
0021-972X
DOI
10.1210/JC.2015-1976
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7031588
handle
http://hdl.handle.net/1854/LU-7031588
date created
2016-01-11 09:47:36
date last changed
2016-12-19 15:47:34
@article{7031588,
  abstract     = {Context: New types of dietary exposure biomarkers are needed to implement effective strategies for obesity prevention in children. Of special interest are biomarkers of consumption of food rich in simple sugars and fat because their intake has been associated with obesity development. Peripheral blood cells (PBCs) represent a promising new tool for identifying novel, transcript-based biomarkers. 
Objective: This study aimed to study potential associations between the transcripts of taste receptor type 1 member 3 (TAS1R3) and urocortin II (UCN2) genes in PBCs and the frequency of sugary and fatty food consumption in children. 
Design, Setting, and Participants: Four hundred sixty-three children from the IDEFICS cohort were selected to include a similar number of boys and girls, both normal-weight and overweight, belonging to eight European countries. 
Main Outcome Measures: Anthropometric parameters (measured at baseline and in a subset of 193 children after 2 years), food consumption frequency and transcript levels of TAS1R3 and UCN2 genes in PBCs were measured. 
Results: Children with low-frequency consumption of sugary foods displayed higher TAS1R3 expression levels with respect to those with intermediate or high frequency. In turn, children with high-frequency consumption of fatty foods showed lower UCN2 expression levels with respect to those with low or intermediate frequency. Moreover, transcripts of TAS1R3 were related with body mass index and fat-mass changes after a 2-year follow-up period, with low expression levels of this gene being related with increased fat accumulation overtime. 
Conclusion: The transcripts of TAS1R3 and UCN2 in PBCs may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires.},
  author       = {Priego, T and S{\'a}nchez, J and Pic{\'o}, C and Ahrens, W and De Henauw, Stefaan and Kourides, Y and Lissner, L and Moln{\'a}r, D and Moreno, LA and Russo, P and Siani, A and Veidebaum, T and Palou, A},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {FISH-OIL SUPPLEMENTATION,MONONUCLEAR-CELLS,GENE-EXPRESSION PROFILES,WHOLE-BLOOD,INDUCED OBESITY,UROCORTIN 2,IDEFICS,DIET,RISK,IDENTIFICATION},
  language     = {eng},
  number       = {9},
  pages        = {3556--3564},
  title        = {TAS1R3 and UCN2 transcript levels in blood cells are associated with sugary and fatty food consumption in children},
  url          = {http://dx.doi.org/10.1210/JC.2015-1976},
  volume       = {100},
  year         = {2015},
}

Chicago
Priego, T, J Sánchez, C Picó, W Ahrens, Stefaan De Henauw, Y Kourides, L Lissner, et al. 2015. “TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated with Sugary and Fatty Food Consumption in Children.” Journal of Clinical Endocrinology & Metabolism 100 (9): 3556–3564.
APA
Priego, T., Sánchez, J., Picó, C., Ahrens, W., De Henauw, S., Kourides, Y., Lissner, L., et al. (2015). TAS1R3 and UCN2 transcript levels in blood cells are associated with sugary and fatty food consumption in children. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 100(9), 3556–3564.
Vancouver
1.
Priego T, Sánchez J, Picó C, Ahrens W, De Henauw S, Kourides Y, et al. TAS1R3 and UCN2 transcript levels in blood cells are associated with sugary and fatty food consumption in children. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(9):3556–64.
MLA
Priego, T, J Sánchez, C Picó, et al. “TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated with Sugary and Fatty Food Consumption in Children.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 100.9 (2015): 3556–3564. Print.