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Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study

(2014) PEDIATRIC RESEARCH. 75(6). p.798-802
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Abstract
BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and gamma-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed. RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted beta = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and beta = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
Keywords
FATTY LIVER, METABOLIC RISK-FACTORS, INSULIN-RESISTANCE, ALANINE AMINOTRANSFERASE, CARDIOVASCULAR RISK, LIFE-STYLE, BODY-FAT, CHILDREN, DISEASE, YOUTH

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MLA
Ruiz, Jonatan R et al. “Physical Activity, Sedentary Time, and Liver Enzymes in Adolescents: The HELENA Study.” PEDIATRIC RESEARCH 75.6 (2014): 798–802. Print.
APA
Ruiz, J. R., Labayen, I., Ortega, F. B., Moreno, L. A., Rodriguez, G., Breidenassel, C., Manios, Y., et al. (2014). Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study. PEDIATRIC RESEARCH, 75(6), 798–802.
Chicago author-date
Ruiz, Jonatan R, Idoia Labayen, Francisco B Ortega, Luis A Moreno, Gerardo Rodriguez, Christina Breidenassel, Yannis Manios, et al. 2014. “Physical Activity, Sedentary Time, and Liver Enzymes in Adolescents: The HELENA Study.” Pediatric Research 75 (6): 798–802.
Chicago author-date (all authors)
Ruiz, Jonatan R, Idoia Labayen, Francisco B Ortega, Luis A Moreno, Gerardo Rodriguez, Christina Breidenassel, Yannis Manios, Anthony Kafatos, Denes Molnar, Stefaan De Henauw, Frederic Gottrand, Kurt Widhalm, Manuel J Castillo, and Michael Sjöström. 2014. “Physical Activity, Sedentary Time, and Liver Enzymes in Adolescents: The HELENA Study.” Pediatric Research 75 (6): 798–802.
Vancouver
1.
Ruiz JR, Labayen I, Ortega FB, Moreno LA, Rodriguez G, Breidenassel C, et al. Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study. PEDIATRIC RESEARCH. 2014;75(6):798–802.
IEEE
[1]
J. R. Ruiz et al., “Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study,” PEDIATRIC RESEARCH, vol. 75, no. 6, pp. 798–802, 2014.
@article{7030468,
  abstract     = {BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. 
METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and gamma-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed. 
RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted beta = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and beta = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. 
CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.},
  author       = {Ruiz, Jonatan R and Labayen, Idoia and Ortega, Francisco B and Moreno, Luis A and Rodriguez, Gerardo and Breidenassel, Christina and Manios, Yannis and Kafatos, Anthony and Molnar, Denes and De Henauw, Stefaan and Gottrand, Frederic and Widhalm, Kurt and Castillo, Manuel J and Sjöström, Michael},
  issn         = {0031-3998},
  journal      = {PEDIATRIC RESEARCH},
  keywords     = {FATTY LIVER,METABOLIC RISK-FACTORS,INSULIN-RESISTANCE,ALANINE AMINOTRANSFERASE,CARDIOVASCULAR RISK,LIFE-STYLE,BODY-FAT,CHILDREN,DISEASE,YOUTH},
  language     = {eng},
  number       = {6},
  pages        = {798--802},
  title        = {Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study},
  url          = {http://dx.doi.org/10.1038/pr.2014.26},
  volume       = {75},
  year         = {2014},
}

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