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Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study

Jonatan R Ruiz, Idoia Labayen, Francisco B Ortega, Luis A Moreno, Gerardo Rodriguez, Christina Breidenassel, Yannis Manios, Anthony Kafatos, Denes Molnar, Stefaan De Henauw UGent, et al. (2014) PEDIATRIC RESEARCH. 75(6). p.798-802
abstract
BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and gamma-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed. RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted beta = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and beta = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FATTY LIVER, METABOLIC RISK-FACTORS, INSULIN-RESISTANCE, ALANINE AMINOTRANSFERASE, CARDIOVASCULAR RISK, LIFE-STYLE, BODY-FAT, CHILDREN, DISEASE, YOUTH
journal title
PEDIATRIC RESEARCH
Pediatr. Res.
volume
75
issue
6
pages
798 - 802
Web of Science type
Article
Web of Science id
000336197300017
JCR category
PEDIATRICS
JCR impact factor
2.314 (2014)
JCR rank
29/120 (2014)
JCR quartile
1 (2014)
ISSN
0031-3998
DOI
10.1038/pr.2014.26
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7030468
handle
http://hdl.handle.net/1854/LU-7030468
date created
2016-01-11 09:42:27
date last changed
2016-12-19 15:39:13
@article{7030468,
  abstract     = {BACKGROUND: To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries. 
METHODS: The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and gamma-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed. 
RESULTS: There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted beta = 0.096, 95\% confidence interval (CI): 0.016 to 0.118; and beta = 0.090, 95\% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels. 
CONCLUSION: Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.},
  author       = {Ruiz, Jonatan R and Labayen, Idoia and Ortega, Francisco B and Moreno, Luis A and Rodriguez, Gerardo and Breidenassel, Christina and Manios, Yannis and Kafatos, Anthony and Molnar, Denes and De Henauw, Stefaan and Gottrand, Frederic and Widhalm, Kurt and Castillo, Manuel J and Sj{\"o}str{\"o}m, Michael},
  issn         = {0031-3998},
  journal      = {PEDIATRIC RESEARCH},
  keyword      = {FATTY LIVER,METABOLIC RISK-FACTORS,INSULIN-RESISTANCE,ALANINE AMINOTRANSFERASE,CARDIOVASCULAR RISK,LIFE-STYLE,BODY-FAT,CHILDREN,DISEASE,YOUTH},
  language     = {eng},
  number       = {6},
  pages        = {798--802},
  title        = {Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study},
  url          = {http://dx.doi.org/10.1038/pr.2014.26},
  volume       = {75},
  year         = {2014},
}

Chicago
Ruiz, Jonatan R, Idoia Labayen, Francisco B Ortega, Luis A Moreno, Gerardo Rodriguez, Christina Breidenassel, Yannis Manios, et al. 2014. “Physical Activity, Sedentary Time, and Liver Enzymes in Adolescents: The HELENA Study.” Pediatric Research 75 (6): 798–802.
APA
Ruiz, J. R., Labayen, I., Ortega, F. B., Moreno, L. A., Rodriguez, G., Breidenassel, C., Manios, Y., et al. (2014). Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study. PEDIATRIC RESEARCH, 75(6), 798–802.
Vancouver
1.
Ruiz JR, Labayen I, Ortega FB, Moreno LA, Rodriguez G, Breidenassel C, et al. Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study. PEDIATRIC RESEARCH. 2014;75(6):798–802.
MLA
Ruiz, Jonatan R, Idoia Labayen, Francisco B Ortega, et al. “Physical Activity, Sedentary Time, and Liver Enzymes in Adolescents: The HELENA Study.” PEDIATRIC RESEARCH 75.6 (2014): 798–802. Print.