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Divergence between the highly virulent zoonotic pathogen Helicobacter heilmannii and its closest relative, the low-virulence 'Helicobacter ailurogastricus' sp. nov.

Myrthe Joosten (UGent) , Sara Lindén, Mirko Rossi, Alfred Chin Yen Tay, Emma Skoog, Médea Padra, Fanny Peters, Tim Perkins, Peter Vandamme (UGent) , Filip Van Nieuwerburgh (UGent) , et al.
(2016) INFECTION AND IMMUNITY. 84(1). p.293-306
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Abstract
Helicobacter heilmannii naturally colonizes the stomachs of dogs and cats and has been associated with gastric disorders in humans. Nine feline Helicobacter strains, classified as H. heilmannii based on ureAB and 16S rRNA gene sequences, were divided into a highly virulent and a low-virulence group. The genomes of these strains were sequenced to investigate their phylogenetic relationships, to define their gene content and diversity, and to determine if the differences in pathogenicity were associated with the presence or absence of potential virulence genes. The capacities of these helicobacters to bind to the gastric mucosa were investigated as well. Our analyses revealed that the low-virulence strains do not belong to the species H. heilmannii but to a novel, closely related species for which we propose the name Helicobacter ailurogastricus. Several homologs of H. pylori virulence factors, such as IceA1, HrgA, and jhp0562-like glycosyltransferase, are present in H. heilmannii but absent in H. ailurogastricus. Both species contain a VacA-like autotransporter, for which the passenger domain is remarkably larger in H. ailurogastricus than in H. heilmannii. In addition, H. ailurogastricus shows clear differences in binding to the gastric mucosa compared to H. heilmannii. These findings highlight the low-virulence character of this novel Helicobacter species.
Keywords
MALT LYMPHOMA, INFECTION, PHASE VARIATION, PYLORI BINDING, BIZZOZERONII, SUBSYSTEMS TECHNOLOGY, COMPARATIVE GENOMICS, GASTRIC EPITHELIAL-CELLS, Helicobacter ailurogastricus sp. nov., Helicobacter heilmannii, MULTIPLE SEQUENCE ALIGNMENT, OUTER-MEMBRANE PROTEINS

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Citation

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MLA
Joosten, Myrthe, et al. “Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter Heilmannii and Its Closest Relative, the Low-Virulence ‘Helicobacter Ailurogastricus’ Sp. Nov.” INFECTION AND IMMUNITY, vol. 84, no. 1, 2016, pp. 293–306, doi:10.1128/IAI.01300-15.
APA
Joosten, M., Lindén, S., Rossi, M., Chin Yen Tay, A., Skoog, E., Padra, M., … Smet, A. (2016). Divergence between the highly virulent zoonotic pathogen Helicobacter heilmannii and its closest relative, the low-virulence “Helicobacter ailurogastricus” sp. nov. INFECTION AND IMMUNITY, 84(1), 293–306. https://doi.org/10.1128/IAI.01300-15
Chicago author-date
Joosten, Myrthe, Sara Lindén, Mirko Rossi, Alfred Chin Yen Tay, Emma Skoog, Médea Padra, Fanny Peters, et al. 2016. “Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter Heilmannii and Its Closest Relative, the Low-Virulence ‘Helicobacter Ailurogastricus’ Sp. Nov.” INFECTION AND IMMUNITY 84 (1): 293–306. https://doi.org/10.1128/IAI.01300-15.
Chicago author-date (all authors)
Joosten, Myrthe, Sara Lindén, Mirko Rossi, Alfred Chin Yen Tay, Emma Skoog, Médea Padra, Fanny Peters, Tim Perkins, Peter Vandamme, Filip Van Nieuwerburgh, Katharina D’Herde, Wim Van Den Broeck, Bram Flahou, Dieter Deforce, Richard Ducatelle, Barry Marshall, Freddy Haesebrouck, and Annemieke Smet. 2016. “Divergence between the Highly Virulent Zoonotic Pathogen Helicobacter Heilmannii and Its Closest Relative, the Low-Virulence ‘Helicobacter Ailurogastricus’ Sp. Nov.” INFECTION AND IMMUNITY 84 (1): 293–306. doi:10.1128/IAI.01300-15.
Vancouver
1.
Joosten M, Lindén S, Rossi M, Chin Yen Tay A, Skoog E, Padra M, et al. Divergence between the highly virulent zoonotic pathogen Helicobacter heilmannii and its closest relative, the low-virulence “Helicobacter ailurogastricus” sp. nov. INFECTION AND IMMUNITY. 2016;84(1):293–306.
IEEE
[1]
M. Joosten et al., “Divergence between the highly virulent zoonotic pathogen Helicobacter heilmannii and its closest relative, the low-virulence ‘Helicobacter ailurogastricus’ sp. nov.,” INFECTION AND IMMUNITY, vol. 84, no. 1, pp. 293–306, 2016.
@article{7029558,
  abstract     = {{Helicobacter heilmannii naturally colonizes the stomachs of dogs and cats and has been associated with gastric disorders in humans. Nine feline Helicobacter strains, classified as H. heilmannii based on ureAB and 16S rRNA gene sequences, were divided into a highly virulent and a low-virulence group. The genomes of these strains were sequenced to investigate their phylogenetic relationships, to define their gene content and diversity, and to determine if the differences in pathogenicity were associated with the presence or absence of potential virulence genes. The capacities of these helicobacters to bind to the gastric mucosa were investigated as well. Our analyses revealed that the low-virulence strains do not belong to the species H. heilmannii but to a novel, closely related species for which we propose the name Helicobacter ailurogastricus. Several homologs of H. pylori virulence factors, such as IceA1, HrgA, and jhp0562-like glycosyltransferase, are present in H. heilmannii but absent in H. ailurogastricus. Both species contain a VacA-like autotransporter, for which the passenger domain is remarkably larger in H. ailurogastricus than in H. heilmannii. In addition, H. ailurogastricus shows clear differences in binding to the gastric mucosa compared to H. heilmannii. These findings highlight the low-virulence character of this novel Helicobacter species.}},
  author       = {{Joosten, Myrthe and Lindén, Sara and Rossi, Mirko and Chin Yen Tay, Alfred and Skoog, Emma and Padra, Médea and Peters, Fanny and Perkins, Tim and Vandamme, Peter and Van Nieuwerburgh, Filip and D'Herde, Katharina and Van Den Broeck, Wim and Flahou, Bram and Deforce, Dieter and Ducatelle, Richard and Marshall, Barry and Haesebrouck, Freddy and Smet, Annemieke}},
  issn         = {{0019-9567}},
  journal      = {{INFECTION AND IMMUNITY}},
  keywords     = {{MALT LYMPHOMA,INFECTION,PHASE VARIATION,PYLORI BINDING,BIZZOZERONII,SUBSYSTEMS TECHNOLOGY,COMPARATIVE GENOMICS,GASTRIC EPITHELIAL-CELLS,Helicobacter ailurogastricus sp. nov.,Helicobacter heilmannii,MULTIPLE SEQUENCE ALIGNMENT,OUTER-MEMBRANE PROTEINS}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{293--306}},
  title        = {{Divergence between the highly virulent zoonotic pathogen Helicobacter heilmannii and its closest relative, the low-virulence 'Helicobacter ailurogastricus' sp. nov.}},
  url          = {{http://doi.org/10.1128/IAI.01300-15}},
  volume       = {{84}},
  year         = {{2016}},
}
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