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Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS

(2015) RHEUMATOLOGY. 54(4). p.633-640
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Abstract
Objective. The aim of this study was to identify characteristics associated with the presence and development of extra-articular manifestations (EAMs) in a prevalence cohort of patients with AS. Methods. Twelve-year follow-up data from the Outcome in Ankylosing Spondylitis International Study (OASIS) were used. In addition, medical charts were checked for the presence of acute anterior uveitis (AAU), IBD and psoriasis. Demographic, clinical and radiographic characteristics associated with the presence of (any) EAM at baseline or new development during follow-up were identified. Results. Two hundred and sixteen patients were included [mean age 43.6 years (S.D. 12.7), 154 (71%) men, mean symptom duration 20.5 years (S.D. 11.7), mean follow-up 8.3 years (S.D. 4.3)]. At baseline, 39 (18%) patients had AAU, 15 (7%) had IBD and 9 (4%) had psoriasis. The history of AAU was univariably associated with increased age [odds ratio (OR) 1.04 (95% CI 1.01, 1.07)], longer symptom duration [OR 1.05 (95% CI 1.02, 1.08)] and more radiographic damage [OR 1.02 (95% CI 1.00, 1.04)]. The history of psoriasis was associated with greater age [OR 1.05 (95% CI 1.00, 1.11)] and lower CRP [OR 0.77 (95% CI 0.59, 1.00)]. At follow-up, 27 patients developed a new EAM. Newly developed IBD was associated with a higher time-varying AS Disease Activity Score [hazard ratio (HR) 2.80 (95% CI 1.43, 5.52)], worse physical function [HR 1.40 (95% CI 1.09, 1.80)] and worse patient global well-being [HR 1.46 (95% CI 1.10, 1.93)]. Newly developed AAU was associated with an elevated time-varying CRP [HR 1.02 (95% CI 1.01, 1.04)]. Conclusion. Development of EAMs was infrequent in this cohort, despite relatively long follow-up. In particular, markers of disease activity were associated with the development of IBD.
Keywords
anterior uveitis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, SOCIETY CLASSIFICATION CRITERIA, INFLAMMATORY BOWEL DISEASES, AXIAL SPONDYLOARTHRITIS, BACK-PAIN, BATH, PREVALENCE, INDEX, PHENOTYPE, PSORIASIS, THERAPY

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MLA
Essers, Ivette et al. “Characteristics Associated with the Presence and Development of Extra-articular Manifestations in Ankylosing Spondylitis: 12-year Results from OASIS.” RHEUMATOLOGY 54.4 (2015): 633–640. Print.
APA
Essers, I., Ramiro, S., Stolwijk, C., Blaauw, M., Landewé, R., van der Heijde, D., Van den Bosch, F., et al. (2015). Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS. RHEUMATOLOGY, 54(4), 633–640.
Chicago author-date
Essers, Ivette, Sofia Ramiro, Carmen Stolwijk, Marc Blaauw, Robert Landewé, Désirée van der Heijde, Filip Van den Bosch, Maxime Dougados, and Astrid van Tubergen. 2015. “Characteristics Associated with the Presence and Development of Extra-articular Manifestations in Ankylosing Spondylitis: 12-year Results from OASIS.” Rheumatology 54 (4): 633–640.
Chicago author-date (all authors)
Essers, Ivette, Sofia Ramiro, Carmen Stolwijk, Marc Blaauw, Robert Landewé, Désirée van der Heijde, Filip Van den Bosch, Maxime Dougados, and Astrid van Tubergen. 2015. “Characteristics Associated with the Presence and Development of Extra-articular Manifestations in Ankylosing Spondylitis: 12-year Results from OASIS.” Rheumatology 54 (4): 633–640.
Vancouver
1.
Essers I, Ramiro S, Stolwijk C, Blaauw M, Landewé R, van der Heijde D, et al. Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS. RHEUMATOLOGY. 2015;54(4):633–40.
IEEE
[1]
I. Essers et al., “Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS,” RHEUMATOLOGY, vol. 54, no. 4, pp. 633–640, 2015.
@article{7025465,
  abstract     = {Objective. The aim of this study was to identify characteristics associated with the presence and development of extra-articular manifestations (EAMs) in a prevalence cohort of patients with AS. 
Methods. Twelve-year follow-up data from the Outcome in Ankylosing Spondylitis International Study (OASIS) were used. In addition, medical charts were checked for the presence of acute anterior uveitis (AAU), IBD and psoriasis. Demographic, clinical and radiographic characteristics associated with the presence of (any) EAM at baseline or new development during follow-up were identified. 
Results. Two hundred and sixteen patients were included [mean age 43.6 years (S.D. 12.7), 154 (71%) men, mean symptom duration 20.5 years (S.D. 11.7), mean follow-up 8.3 years (S.D. 4.3)]. At baseline, 39 (18%) patients had AAU, 15 (7%) had IBD and 9 (4%) had psoriasis. The history of AAU was univariably associated with increased age [odds ratio (OR) 1.04 (95% CI 1.01, 1.07)], longer symptom duration [OR 1.05 (95% CI 1.02, 1.08)] and more radiographic damage [OR 1.02 (95% CI 1.00, 1.04)]. The history of psoriasis was associated with greater age [OR 1.05 (95% CI 1.00, 1.11)] and lower CRP [OR 0.77 (95% CI 0.59, 1.00)]. At follow-up, 27 patients developed a new EAM. Newly developed IBD was associated with a higher time-varying AS Disease Activity Score [hazard ratio (HR) 2.80 (95% CI 1.43, 5.52)], worse physical function [HR 1.40 (95% CI 1.09, 1.80)] and worse patient global well-being [HR 1.46 (95% CI 1.10, 1.93)]. Newly developed AAU was associated with an elevated time-varying CRP [HR 1.02 (95% CI 1.01, 1.04)]. 
Conclusion. Development of EAMs was infrequent in this cohort, despite relatively long follow-up. In particular, markers of disease activity were associated with the development of IBD.},
  author       = {Essers, Ivette and Ramiro, Sofia and Stolwijk, Carmen and Blaauw, Marc and Landewé, Robert and van der Heijde, Désirée and Van den Bosch, Filip and Dougados, Maxime and van Tubergen, Astrid},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {anterior uveitis,ankylosing spondylitis,inflammatory bowel disease,psoriasis,SOCIETY CLASSIFICATION CRITERIA,INFLAMMATORY BOWEL DISEASES,AXIAL SPONDYLOARTHRITIS,BACK-PAIN,BATH,PREVALENCE,INDEX,PHENOTYPE,PSORIASIS,THERAPY},
  language     = {eng},
  number       = {4},
  pages        = {633--640},
  title        = {Characteristics associated with the presence and development of extra-articular manifestations in ankylosing spondylitis: 12-year results from OASIS},
  url          = {http://dx.doi.org/10.1093/rheumatology/keu388},
  volume       = {54},
  year         = {2015},
}

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