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The effect of experimental low back pain on lumbar muscle activity in people with a history of clinical low back pain: a muscle functional MRI study

Lieven Danneels (UGent) , Barbara Cagnie (UGent) , Roseline D'hooge (UGent) , Yves De Deene (UGent) , Geert Crombez (UGent) , Guy Vanderstraeten (UGent) , Thierry Parlevliet (UGent) and Jessica Van Oosterwijck (UGent)
(2016) JOURNAL OF NEUROPHYSIOLOGY. 115(2). p.851-857
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Abstract
In people with a history of low back pain (LBP), structural and functional alterations have been observed at several peripheral and central levels of the sensorimotor pathway. These existing alterations might interact with the way the sensorimotor system responds to pain. We examined this assumption by evaluating the lumbar motor responses to experimental nociceptive input of 15 participants during remission of unilateral recurrent LBP. Quantitative T2 images (muscle functional MRI) were taken bilaterally of multifidus, erector spinae, and psoas at several segmental levels (L3 upper and L4 upper and lower endplate) and during several conditions: 1) at rest, 2) upon trunk-extension exercise without pain, and 3) upon trunk-extension exercise with experimental induced pain at the clinical pain-side (1.5-ml intramuscular hypertonic saline injections in erector spinae). Following experimental pain induction, muscle activity levels similarly reduced for all three muscles, on both painful and nonpainful sides, and at multiple segmental levels (P = 0.038). Pain intensity and localization from experimental LBP were similar as during recalled clinical LBP episodes. In conclusion, unilateral and unisegmental experimental LBP exerts a generalized and widespread decrease in lumbar muscle activity during remission of recurrent LBP. This muscle response is consistent with previous observed patterns in healthy people subjected to the same experimental pain paradigm. It is striking that similar inhibitory patterns in response to pain could be observed, despite the presence of preexisting alterations in the lumbar musculature during remission of recurrent LBP. These results suggest that motor output can modify along the course of recurrent LBP.
Keywords
ACTIVATION, STRATEGY, INDIVIDUALS, ELECTROMYOGRAPHY, REMISSION, MULTIFIDUS, TRUNK MUSCLES, muscle recruitment, lumbar paraspinal muscles, muscle functional magnetic resonance imaging, experimental muscle pain, recurrent low back pain

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MLA
Danneels, Lieven et al. “The Effect of Experimental Low Back Pain on Lumbar Muscle Activity in People with a History of Clinical Low Back Pain: a Muscle Functional MRI Study.” JOURNAL OF NEUROPHYSIOLOGY 115.2 (2016): 851–857. Print.
APA
Danneels, L., Cagnie, B., D’hooge, R., De Deene, Y., Crombez, G., Vanderstraeten, G., Parlevliet, T., et al. (2016). The effect of experimental low back pain on lumbar muscle activity in people with a history of clinical low back pain: a muscle functional MRI study. JOURNAL OF NEUROPHYSIOLOGY, 115(2), 851–857.
Chicago author-date
Danneels, Lieven, Barbara Cagnie, Roseline D’hooge, Yves De Deene, Geert Crombez, Guy Vanderstraeten, Thierry Parlevliet, and Jessica Van Oosterwijck. 2016. “The Effect of Experimental Low Back Pain on Lumbar Muscle Activity in People with a History of Clinical Low Back Pain: a Muscle Functional MRI Study.” Journal of Neurophysiology 115 (2): 851–857.
Chicago author-date (all authors)
Danneels, Lieven, Barbara Cagnie, Roseline D’hooge, Yves De Deene, Geert Crombez, Guy Vanderstraeten, Thierry Parlevliet, and Jessica Van Oosterwijck. 2016. “The Effect of Experimental Low Back Pain on Lumbar Muscle Activity in People with a History of Clinical Low Back Pain: a Muscle Functional MRI Study.” Journal of Neurophysiology 115 (2): 851–857.
Vancouver
1.
Danneels L, Cagnie B, D’hooge R, De Deene Y, Crombez G, Vanderstraeten G, et al. The effect of experimental low back pain on lumbar muscle activity in people with a history of clinical low back pain: a muscle functional MRI study. JOURNAL OF NEUROPHYSIOLOGY. 2016;115(2):851–7.
IEEE
[1]
L. Danneels et al., “The effect of experimental low back pain on lumbar muscle activity in people with a history of clinical low back pain: a muscle functional MRI study,” JOURNAL OF NEUROPHYSIOLOGY, vol. 115, no. 2, pp. 851–857, 2016.
@article{7021694,
  abstract     = {In people with a history of low back pain (LBP), structural and functional alterations have been observed at several peripheral and central levels of the sensorimotor pathway. These existing alterations might interact with the way the sensorimotor system responds to pain. We examined this assumption by evaluating the lumbar motor responses to experimental nociceptive input of 15 participants during remission of unilateral recurrent LBP. Quantitative T2 images (muscle functional MRI) were taken bilaterally of multifidus, erector spinae, and psoas at several segmental levels (L3 upper and L4 upper and lower endplate) and during several conditions: 1) at rest, 2) upon trunk-extension exercise without pain, and 3) upon trunk-extension exercise with experimental induced pain at the clinical pain-side (1.5-ml intramuscular hypertonic saline injections in erector spinae). Following experimental pain induction, muscle activity levels similarly reduced for all three muscles, on both painful and nonpainful sides, and at multiple segmental levels (P = 0.038). Pain intensity and localization from experimental LBP were similar as during recalled clinical LBP episodes. In conclusion, unilateral and unisegmental experimental LBP exerts a generalized and widespread decrease in lumbar muscle activity during remission of recurrent LBP. This muscle response is consistent with previous observed patterns in healthy people subjected to the same experimental pain paradigm. It is striking that similar inhibitory patterns in response to pain could be observed, despite the presence of preexisting alterations in the lumbar musculature during remission of recurrent LBP. These results suggest that motor output can modify along the course of recurrent LBP.},
  author       = {Danneels, Lieven and Cagnie, Barbara and D'hooge, Roseline and De Deene, Yves and Crombez, Geert and Vanderstraeten, Guy and Parlevliet, Thierry and Van Oosterwijck, Jessica},
  issn         = {0022-3077},
  journal      = {JOURNAL OF NEUROPHYSIOLOGY},
  keywords     = {ACTIVATION,STRATEGY,INDIVIDUALS,ELECTROMYOGRAPHY,REMISSION,MULTIFIDUS,TRUNK MUSCLES,muscle recruitment,lumbar paraspinal muscles,muscle functional magnetic resonance imaging,experimental muscle pain,recurrent low back pain},
  language     = {eng},
  number       = {2},
  pages        = {851--857},
  title        = {The effect of experimental low back pain on lumbar muscle activity in people with a history of clinical low back pain: a muscle functional MRI study},
  url          = {http://dx.doi.org/10.1152/jn.00192.2015},
  volume       = {115},
  year         = {2016},
}

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