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Acacia gum improves the gut barrier functionality in vitro

(2015) AGRO FOOD INDUSTRY HI-TECH. 26(4). p.29-33
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Abstract
The Leaky Gut Syndrome - impairment of the gut wall functionality - is involved in many inflammatory diseases, among them IBS. The aim of this work was to evaluate the effect of arabinogalactan (AG) and fructo-oligosaccharides (FOS) on gut wall modulation using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME(R)) inoculated with faecal material from an IBS donor-coupled with co-cultures of enterocytes and macrophages (transwell approach using Caco-2 and THP1 cells). AG and FOS showed a different fermentation profile (more proximal for FOS and distal for AG) and both fibres exerted a potential positive effect on gut barrier (increased TEER parameter) and inflammation (modulation of cytokines IL-8, IL-6, IL-10 and NF-kappa B) in their main area of fermentation. AG could be an interesting nutritional supplement for the treatment of those conditions characterized by inflammation and increased permeability in the distal colon.
Keywords
IBS, Fibregum, gut inflammation, SHIME (R), colonic fermentation, Gut permeability, INTESTINAL MICROBIAL ECOSYSTEM, IRRITABLE-BOWEL-SYNDROME, CHAIN FATTY-ACIDS, FERMENTATION PROFILE, DISEASE PATHOGENESIS, KAPPA-B, INFLAMMATION, HOMEOSTASIS, SIMULATOR, HEALTH

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Chicago
Daguet, David, Iris Pinheiro, An Verhelst, Sam Possemiers, and Massimo Marzorati. 2015. “Acacia Gum Improves the Gut Barrier Functionality in Vitro.” Agro Food Industry Hi-tech 26 (4): 29–33.
APA
Daguet, D., Pinheiro, I., Verhelst, A., Possemiers, S., & Marzorati, M. (2015). Acacia gum improves the gut barrier functionality in vitro. AGRO FOOD INDUSTRY HI-TECH, 26(4), 29–33.
Vancouver
1.
Daguet D, Pinheiro I, Verhelst A, Possemiers S, Marzorati M. Acacia gum improves the gut barrier functionality in vitro. AGRO FOOD INDUSTRY HI-TECH. 2015;26(4):29–33.
MLA
Daguet, David, Iris Pinheiro, An Verhelst, et al. “Acacia Gum Improves the Gut Barrier Functionality in Vitro.” AGRO FOOD INDUSTRY HI-TECH 26.4 (2015): 29–33. Print.
@article{7021012,
  abstract     = {The Leaky Gut Syndrome - impairment of the gut wall functionality - is involved in many inflammatory diseases, among them IBS. The aim of this work was to evaluate the effect of arabinogalactan (AG) and fructo-oligosaccharides (FOS) on gut wall modulation using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME(R)) inoculated with faecal material from an IBS donor-coupled with co-cultures of enterocytes and macrophages (transwell approach using Caco-2 and THP1 cells). AG and FOS showed a different fermentation profile (more proximal for FOS and distal for AG) and both fibres exerted a potential positive effect on gut barrier (increased TEER parameter) and inflammation (modulation of cytokines IL-8, IL-6, IL-10 and NF-kappa B) in their main area of fermentation. AG could be an interesting nutritional supplement for the treatment of those conditions characterized by inflammation and increased permeability in the distal colon.},
  author       = {Daguet, David and Pinheiro, Iris and Verhelst, An and Possemiers, Sam and Marzorati, Massimo},
  issn         = {1722-6996},
  journal      = {AGRO FOOD INDUSTRY HI-TECH},
  keyword      = {IBS,Fibregum,gut inflammation,SHIME (R),colonic fermentation,Gut permeability,INTESTINAL MICROBIAL ECOSYSTEM,IRRITABLE-BOWEL-SYNDROME,CHAIN FATTY-ACIDS,FERMENTATION PROFILE,DISEASE PATHOGENESIS,KAPPA-B,INFLAMMATION,HOMEOSTASIS,SIMULATOR,HEALTH},
  language     = {eng},
  number       = {4},
  pages        = {29--33},
  title        = {Acacia gum improves the gut barrier functionality in vitro},
  volume       = {26},
  year         = {2015},
}

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