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Protein modification and maintenance systems as biomarkers of ageing

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Abstract
Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.
Keywords
Protein modification, Protein maintenance, Biomarkers, Ageing, METHIONINE-SULFOXIDE-REDUCTASE, GLYCATION END-PRODUCTS, HIGH-DENSITY-LIPOPROTEIN, UBIQUITIN-PROTEASOME PATHWAY, HUMAN EMBRYONIC FIBROBLASTS, TYPE-2 DIABETES-MELLITUS, GENOME-WIDE ASSOCIATION, CORONARY-HEART-DISEASE, HUMAN BJ FIBROBLASTS, LIFE-SPAN EXTENSION

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Citation

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MLA
Vanhooren, Valerie et al. “Protein Modification and Maintenance Systems as Biomarkers of Ageing.” MECHANISMS OF AGEING AND DEVELOPMENT 151 (2015): 71–84. Print.
APA
Vanhooren, V., Santos, A. N., Voutetakis, K., Petropoulos, I., Libert, C., Simm, A., Gonos, E. S., et al. (2015). Protein modification and maintenance systems as biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 151, 71–84.
Chicago author-date
Vanhooren, Valerie, Alexander Navarrete Santos, Konstantinos Voutetakis, Isabelle Petropoulos, Claude Libert, Andreas Simm, Efstathios S Gonos, and Bertrand Friguet. 2015. “Protein Modification and Maintenance Systems as Biomarkers of Ageing.” Mechanisms of Ageing and Development 151: 71–84.
Chicago author-date (all authors)
Vanhooren, Valerie, Alexander Navarrete Santos, Konstantinos Voutetakis, Isabelle Petropoulos, Claude Libert, Andreas Simm, Efstathios S Gonos, and Bertrand Friguet. 2015. “Protein Modification and Maintenance Systems as Biomarkers of Ageing.” Mechanisms of Ageing and Development 151: 71–84.
Vancouver
1.
Vanhooren V, Santos AN, Voutetakis K, Petropoulos I, Libert C, Simm A, et al. Protein modification and maintenance systems as biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT. 2015;151:71–84.
IEEE
[1]
V. Vanhooren et al., “Protein modification and maintenance systems as biomarkers of ageing,” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 151, pp. 71–84, 2015.
@article{7019859,
  abstract     = {Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.},
  author       = {Vanhooren, Valerie and Santos, Alexander Navarrete and Voutetakis, Konstantinos and Petropoulos, Isabelle and Libert, Claude and Simm, Andreas and Gonos, Efstathios S and Friguet, Bertrand},
  issn         = {0047-6374},
  journal      = {MECHANISMS OF AGEING AND DEVELOPMENT},
  keywords     = {Protein modification,Protein maintenance,Biomarkers,Ageing,METHIONINE-SULFOXIDE-REDUCTASE,GLYCATION END-PRODUCTS,HIGH-DENSITY-LIPOPROTEIN,UBIQUITIN-PROTEASOME PATHWAY,HUMAN EMBRYONIC FIBROBLASTS,TYPE-2 DIABETES-MELLITUS,GENOME-WIDE ASSOCIATION,CORONARY-HEART-DISEASE,HUMAN BJ FIBROBLASTS,LIFE-SPAN EXTENSION},
  language     = {eng},
  pages        = {71--84},
  title        = {Protein modification and maintenance systems as biomarkers of ageing},
  url          = {http://dx.doi.org/10.1016/j.mad.2015.03.009},
  volume       = {151},
  year         = {2015},
}

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