- Author
- Alexander Bürkle, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan HJ Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R Griffiths, Claude Libert (UGent) , Tilman Grune, Nicolle Breusing, Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P Eline Slagboom, Antti Hervonen, Mikko Hurme and Richard Aspinall
- Organization
- Abstract
- Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
- Keywords
- C-REACTIVE-PROTEIN, INDUCED PREMATURE SENESCENCE, MARK-AGE, Human studies, Ageing biomarkers, APOLIPOPROTEIN-E GENOTYPE, T-CELL SUBSETS, OXIDATIVE STRESS, REPLICATIVE SENESCENCE, MITOCHONDRIAL-DNA, TELOMERE LENGTH, HUMAN LONGEVITY, OLD-AGE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-7019822
- MLA
- Bürkle, Alexander, et al. “MARK-AGE Biomarkers of Ageing.” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 151, 2015, pp. 2–12, doi:10.1016/j.mad.2015.03.006.
- APA
- Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H., … Aspinall, R. (2015). MARK-AGE biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 151, 2–12. https://doi.org/10.1016/j.mad.2015.03.006
- Chicago author-date
- Bürkle, Alexander, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan HJ Hoeijmakers, Olivier Toussaint, et al. 2015. “MARK-AGE Biomarkers of Ageing.” MECHANISMS OF AGEING AND DEVELOPMENT 151: 2–12. https://doi.org/10.1016/j.mad.2015.03.006.
- Chicago author-date (all authors)
- Bürkle, Alexander, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan HJ Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R Griffiths, Claude Libert, Tilman Grune, Nicolle Breusing, Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P Eline Slagboom, Antti Hervonen, Mikko Hurme, and Richard Aspinall. 2015. “MARK-AGE Biomarkers of Ageing.” MECHANISMS OF AGEING AND DEVELOPMENT 151: 2–12. doi:10.1016/j.mad.2015.03.006.
- Vancouver
- 1.Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, et al. MARK-AGE biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT. 2015;151:2–12.
- IEEE
- [1]A. Bürkle et al., “MARK-AGE biomarkers of ageing,” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 151, pp. 2–12, 2015.
@article{7019822, abstract = {{Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.}}, author = {{Bürkle, Alexander and Moreno-Villanueva, María and Bernhard, Jürgen and Blasco, María and Zondag, Gerben and Hoeijmakers, Jan HJ and Toussaint, Olivier and Grubeck-Loebenstein, Beatrix and Mocchegiani, Eugenio and Collino, Sebastiano and Gonos, Efstathios S and Sikora, Ewa and Gradinaru, Daniela and Dollé, Martijn and Salmon, Michel and Kristensen, Peter and Griffiths, Helen R and Libert, Claude and Grune, Tilman and Breusing, Nicolle and Simm, Andreas and Franceschi, Claudio and Capri, Miriam and Talbot, Duncan and Caiafa, Paola and Friguet, Bertrand and Slagboom, P Eline and Hervonen, Antti and Hurme, Mikko and Aspinall, Richard}}, issn = {{0047-6374}}, journal = {{MECHANISMS OF AGEING AND DEVELOPMENT}}, keywords = {{C-REACTIVE-PROTEIN,INDUCED PREMATURE SENESCENCE,MARK-AGE,Human studies,Ageing biomarkers,APOLIPOPROTEIN-E GENOTYPE,T-CELL SUBSETS,OXIDATIVE STRESS,REPLICATIVE SENESCENCE,MITOCHONDRIAL-DNA,TELOMERE LENGTH,HUMAN LONGEVITY,OLD-AGE}}, language = {{eng}}, pages = {{2--12}}, title = {{MARK-AGE biomarkers of ageing}}, url = {{http://doi.org/10.1016/j.mad.2015.03.006}}, volume = {{151}}, year = {{2015}}, }
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