Advanced search
1 file | 903.37 KB Add to list
Author
Organization
Abstract
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
Keywords
C-REACTIVE-PROTEIN, INDUCED PREMATURE SENESCENCE, MARK-AGE, Human studies, Ageing biomarkers, APOLIPOPROTEIN-E GENOTYPE, T-CELL SUBSETS, OXIDATIVE STRESS, REPLICATIVE SENESCENCE, MITOCHONDRIAL-DNA, TELOMERE LENGTH, HUMAN LONGEVITY, OLD-AGE

Downloads

  • 2553 15Burkler.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 903.37 KB

Citation

Please use this url to cite or link to this publication:

MLA
Bürkle, Alexander et al. “MARK-AGE Biomarkers of Ageing.” MECHANISMS OF AGEING AND DEVELOPMENT 151 (2015): 2–12. Print.
APA
Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H., Toussaint, O., et al. (2015). MARK-AGE biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT, 151, 2–12.
Chicago author-date
Bürkle, Alexander, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan HJ Hoeijmakers, Olivier Toussaint, et al. 2015. “MARK-AGE Biomarkers of Ageing.” Mechanisms of Ageing and Development 151: 2–12.
Chicago author-date (all authors)
Bürkle, Alexander, María Moreno-Villanueva, Jürgen Bernhard, María Blasco, Gerben Zondag, Jan HJ Hoeijmakers, Olivier Toussaint, Beatrix Grubeck-Loebenstein, Eugenio Mocchegiani, Sebastiano Collino, Efstathios S Gonos, Ewa Sikora, Daniela Gradinaru, Martijn Dollé, Michel Salmon, Peter Kristensen, Helen R Griffiths, Claude Libert, Tilman Grune, Nicolle Breusing, Andreas Simm, Claudio Franceschi, Miriam Capri, Duncan Talbot, Paola Caiafa, Bertrand Friguet, P Eline Slagboom, Antti Hervonen, Mikko Hurme, and Richard Aspinall. 2015. “MARK-AGE Biomarkers of Ageing.” Mechanisms of Ageing and Development 151: 2–12.
Vancouver
1.
Bürkle A, Moreno-Villanueva M, Bernhard J, Blasco M, Zondag G, Hoeijmakers JH, et al. MARK-AGE biomarkers of ageing. MECHANISMS OF AGEING AND DEVELOPMENT. 2015;151:2–12.
IEEE
[1]
A. Bürkle et al., “MARK-AGE biomarkers of ageing,” MECHANISMS OF AGEING AND DEVELOPMENT, vol. 151, pp. 2–12, 2015.
@article{7019822,
  abstract     = {Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.},
  author       = {Bürkle, Alexander and Moreno-Villanueva, María and Bernhard, Jürgen and Blasco, María and Zondag, Gerben and Hoeijmakers, Jan HJ and Toussaint, Olivier and Grubeck-Loebenstein, Beatrix and Mocchegiani, Eugenio and Collino, Sebastiano and Gonos, Efstathios S and Sikora, Ewa and Gradinaru, Daniela and Dollé, Martijn and Salmon, Michel and Kristensen, Peter and Griffiths, Helen R and Libert, Claude and Grune, Tilman and Breusing, Nicolle and Simm, Andreas and Franceschi, Claudio and Capri, Miriam and Talbot, Duncan and Caiafa, Paola and Friguet, Bertrand and Slagboom, P Eline and Hervonen, Antti and Hurme, Mikko and Aspinall, Richard},
  issn         = {0047-6374},
  journal      = {MECHANISMS OF AGEING AND DEVELOPMENT},
  keywords     = {C-REACTIVE-PROTEIN,INDUCED PREMATURE SENESCENCE,MARK-AGE,Human studies,Ageing biomarkers,APOLIPOPROTEIN-E GENOTYPE,T-CELL SUBSETS,OXIDATIVE STRESS,REPLICATIVE SENESCENCE,MITOCHONDRIAL-DNA,TELOMERE LENGTH,HUMAN LONGEVITY,OLD-AGE},
  language     = {eng},
  pages        = {2--12},
  title        = {MARK-AGE biomarkers of ageing},
  url          = {http://dx.doi.org/10.1016/j.mad.2015.03.006},
  volume       = {151},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: