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The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations

Caro Franck UGent, Charlot Vandevoorde, Ingeborg Goethals UGent, Peter Smeets, Eric Achten UGent, Koenraad Verstraete UGent, Hubert Thierens UGent and Klaus Bacher UGent (2016) EUROPEAN RADIOLOGY. 26(8). p.2646-2655
abstract
To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated. SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models. Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. - Blood dose can be simulated using the patient's clinical CT images. - SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. - SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
X-Ray computed tomography, Radiation dosimetry, Paediatrics, Monte Carlo method, Patient-specific computational modelling, MONTE-CARLO TOOL, COMPUTED-TOMOGRAPHY, RADIATION-EXPOSURE, IN-VIVO, VALIDATION, CHILDREN, SCANS
journal title
EUROPEAN RADIOLOGY
Eur. Radiol.
volume
26
issue
8
pages
2646 - 2655
Web of Science type
Article
Web of Science id
000379192500026
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
3.967 (2016)
JCR rank
15/126 (2016)
JCR quartile
1 (2016)
ISSN
0938-7994
DOI
10.1007/s00330-015-4091-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
7018652
handle
http://hdl.handle.net/1854/LU-7018652
date created
2015-12-21 08:05:37
date last changed
2017-07-04 10:28:47
@article{7018652,
  abstract     = {To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. 
Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated. 
SSDE showed a significant strong linear correlation with organ dose (r {\textrangle} 0.8) and blood dose (r {\textrangle} 0.9) and LAR (r {\textrangle} 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models. 
Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. 
- Blood dose can be simulated using the patient's clinical CT images. 
- SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. 
- SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.},
  author       = {Franck, Caro and Vandevoorde, Charlot and Goethals, Ingeborg and Smeets, Peter and Achten, Eric and Verstraete, Koenraad and Thierens, Hubert and Bacher, Klaus},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keyword      = {X-Ray computed tomography,Radiation dosimetry,Paediatrics,Monte Carlo method,Patient-specific computational modelling,MONTE-CARLO TOOL,COMPUTED-TOMOGRAPHY,RADIATION-EXPOSURE,IN-VIVO,VALIDATION,CHILDREN,SCANS},
  language     = {eng},
  number       = {8},
  pages        = {2646--2655},
  title        = {The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations},
  url          = {http://dx.doi.org/10.1007/s00330-015-4091-7},
  volume       = {26},
  year         = {2016},
}

Chicago
Franck, Caro, Charlot Vandevoorde, Ingeborg Goethals, PETER SMEETS, Eric Achten, Koenraad Verstraete, Hubert Thierens, and Klaus Bacher. 2016. “The Role of Size-Specific Dose Estimate (SSDE) in Patient-specific Organ Dose and Cancer Risk Estimation in Paediatric Chest and Abdominopelvic CT Examinations.” European Radiology 26 (8): 2646–2655.
APA
Franck, C., Vandevoorde, C., Goethals, I., SMEETS, P., Achten, E., Verstraete, K., Thierens, H., et al. (2016). The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations. EUROPEAN RADIOLOGY, 26(8), 2646–2655.
Vancouver
1.
Franck C, Vandevoorde C, Goethals I, SMEETS P, Achten E, Verstraete K, et al. The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations. EUROPEAN RADIOLOGY. 2016;26(8):2646–55.
MLA
Franck, Caro, Charlot Vandevoorde, Ingeborg Goethals, et al. “The Role of Size-Specific Dose Estimate (SSDE) in Patient-specific Organ Dose and Cancer Risk Estimation in Paediatric Chest and Abdominopelvic CT Examinations.” EUROPEAN RADIOLOGY 26.8 (2016): 2646–2655. Print.