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The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations

Caro Franck (UGent) , Charlot Vandevoorde (UGent) , Ingeborg Goethals (UGent) , Peter Smeets (UGent) , Eric Achten (UGent) , Koenraad Verstraete (UGent) , Hubert Thierens (UGent) and Klaus Bacher (UGent)
(2016) EUROPEAN RADIOLOGY. 26(8). p.2646-2655
Author
Organization
Abstract
To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated. SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models. Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. - Blood dose can be simulated using the patient's clinical CT images. - SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. - SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.
Keywords
X-Ray computed tomography, Radiation dosimetry, Paediatrics, Monte Carlo method, Patient-specific computational modelling, MONTE-CARLO TOOL, COMPUTED-TOMOGRAPHY, RADIATION-EXPOSURE, IN-VIVO, VALIDATION, CHILDREN, SCANS

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MLA
Franck, Caro et al. “The Role of Size-Specific Dose Estimate (SSDE) in Patient-specific Organ Dose and Cancer Risk Estimation in Paediatric Chest and Abdominopelvic CT Examinations.” EUROPEAN RADIOLOGY 26.8 (2016): 2646–2655. Print.
APA
Franck, C., Vandevoorde, C., Goethals, I., Smeets, P., Achten, E., Verstraete, K., Thierens, H., et al. (2016). The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations. EUROPEAN RADIOLOGY, 26(8), 2646–2655.
Chicago author-date
Franck, Caro, Charlot Vandevoorde, Ingeborg Goethals, Peter Smeets, Eric Achten, Koenraad Verstraete, Hubert Thierens, and Klaus Bacher. 2016. “The Role of Size-Specific Dose Estimate (SSDE) in Patient-specific Organ Dose and Cancer Risk Estimation in Paediatric Chest and Abdominopelvic CT Examinations.” European Radiology 26 (8): 2646–2655.
Chicago author-date (all authors)
Franck, Caro, Charlot Vandevoorde, Ingeborg Goethals, Peter Smeets, Eric Achten, Koenraad Verstraete, Hubert Thierens, and Klaus Bacher. 2016. “The Role of Size-Specific Dose Estimate (SSDE) in Patient-specific Organ Dose and Cancer Risk Estimation in Paediatric Chest and Abdominopelvic CT Examinations.” European Radiology 26 (8): 2646–2655.
Vancouver
1.
Franck C, Vandevoorde C, Goethals I, Smeets P, Achten E, Verstraete K, et al. The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations. EUROPEAN RADIOLOGY. 2016;26(8):2646–55.
IEEE
[1]
C. Franck et al., “The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations,” EUROPEAN RADIOLOGY, vol. 26, no. 8, pp. 2646–2655, 2016.
@article{7018652,
  abstract     = {To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. 
Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated. 
SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models. 
Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. 
- Blood dose can be simulated using the patient's clinical CT images. 
- SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. 
- SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.},
  author       = {Franck, Caro and Vandevoorde, Charlot and Goethals, Ingeborg and Smeets, Peter and Achten, Eric and Verstraete, Koenraad and Thierens, Hubert and Bacher, Klaus},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keywords     = {X-Ray computed tomography,Radiation dosimetry,Paediatrics,Monte Carlo method,Patient-specific computational modelling,MONTE-CARLO TOOL,COMPUTED-TOMOGRAPHY,RADIATION-EXPOSURE,IN-VIVO,VALIDATION,CHILDREN,SCANS},
  language     = {eng},
  number       = {8},
  pages        = {2646--2655},
  title        = {The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations},
  url          = {http://dx.doi.org/10.1007/s00330-015-4091-7},
  volume       = {26},
  year         = {2016},
}

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