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Assessment of model based (input) impedance, pulse wave velocity, and wave reflection in the Asklepios Cohort

(2015) PLOS ONE. 10(10).
Author
Organization
Abstract
Objectives : Arterial stiffness and wave reflection parameters assessed from both invasive and non-invasive pressure and flow readings are used as surrogates for ventricular and vascular load. They have been reported to predict adverse cardiovascular events, but clinical assessment is laborious and may limit widespread use. This study aims to investigate measures of arterial stiffness and central hemodynamics provided by arterial tonometry alone and in combination with aortic root flows derived by echocardiography against surrogates derived by a mathematical pressure and flow model in a healthy middle-aged cohort. Methods : Measurements of carotid artery tonometry and echocardiography were performed on 2226 ASKLEPIOS study participants and parameters of systemic hemodynamics, arterial stiffness and wave reflection based on pressure and flow were measured. In a second step, the analysis was repeated but echocardiography derived flows were substituted by flows provided by a novel mathematical model. This was followed by a quantitative method comparison. Results : All investigated parameters showed a significant association between the methods. Overall agreement was acceptable for all parameters (mean differences: -0.0102 (0.033 SD) mmHg*s/ml for characteristic impedance, 0.36 (4.21 SD) mmHg for forward pressure amplitude, 2.26 (3.51 SD) mmHg for backward pressure amplitude and 0.717 (1.25 SD) m/s for pulse wave velocity). Conclusion : The results indicate that the use of model-based surrogates in a healthy middle aged cohort is feasible and deserves further attention.
Keywords
NONINVASIVE EVALUATION, EXPERT CONSENSUS DOCUMENT, ARTERIAL STIFFNESS, AORTIC STIFFNESS, ORGAN DAMAGE, PRESSURE, AGE, HEALTHY, WOMEN, QUANTIFICATION

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MLA
Hametner, Bernhard et al. “Assessment of Model Based (input) Impedance, Pulse Wave Velocity, and Wave Reflection in the Asklepios Cohort.” PLOS ONE 10.10 (2015): n. pag. Print.
APA
Hametner, B., Parragh, S., Mayer, C., Weber, T., Van Bortel, L., De Buyzere, M., Segers, P., et al. (2015). Assessment of model based (input) impedance, pulse wave velocity, and wave reflection in the Asklepios Cohort. PLOS ONE, 10(10).
Chicago author-date
Hametner, Bernhard, Stephanie Parragh, Christopher Mayer, Thomas Weber, Lucas Van Bortel, Marc De Buyzere, Patrick Segers, Ernst Rietzschel, and Siegfried Wassertheurer. 2015. “Assessment of Model Based (input) Impedance, Pulse Wave Velocity, and Wave Reflection in the Asklepios Cohort.” Plos One 10 (10).
Chicago author-date (all authors)
Hametner, Bernhard, Stephanie Parragh, Christopher Mayer, Thomas Weber, Lucas Van Bortel, Marc De Buyzere, Patrick Segers, Ernst Rietzschel, and Siegfried Wassertheurer. 2015. “Assessment of Model Based (input) Impedance, Pulse Wave Velocity, and Wave Reflection in the Asklepios Cohort.” Plos One 10 (10).
Vancouver
1.
Hametner B, Parragh S, Mayer C, Weber T, Van Bortel L, De Buyzere M, et al. Assessment of model based (input) impedance, pulse wave velocity, and wave reflection in the Asklepios Cohort. PLOS ONE. 2015;10(10).
IEEE
[1]
B. Hametner et al., “Assessment of model based (input) impedance, pulse wave velocity, and wave reflection in the Asklepios Cohort,” PLOS ONE, vol. 10, no. 10, 2015.
@article{7006636,
  abstract     = {Objectives : Arterial stiffness and wave reflection parameters assessed from both invasive and non-invasive pressure and flow readings are used as surrogates for ventricular and vascular load. They have been reported to predict adverse cardiovascular events, but clinical assessment is laborious and may limit widespread use. This study aims to investigate measures of arterial stiffness and central hemodynamics provided by arterial tonometry alone and in combination with aortic root flows derived by echocardiography against surrogates derived by a mathematical pressure and flow model in a healthy middle-aged cohort. 
Methods : Measurements of carotid artery tonometry and echocardiography were performed on 2226 ASKLEPIOS study participants and parameters of systemic hemodynamics, arterial stiffness and wave reflection based on pressure and flow were measured. In a second step, the analysis was repeated but echocardiography derived flows were substituted by flows provided by a novel mathematical model. This was followed by a quantitative method comparison. 
Results : All investigated parameters showed a significant association between the methods. Overall agreement was acceptable for all parameters (mean differences: -0.0102 (0.033 SD) mmHg*s/ml for characteristic impedance, 0.36 (4.21 SD) mmHg for forward pressure amplitude, 2.26 (3.51 SD) mmHg for backward pressure amplitude and 0.717 (1.25 SD) m/s for pulse wave velocity). 
Conclusion : The results indicate that the use of model-based surrogates in a healthy middle aged cohort is feasible and deserves further attention.},
  articleno    = {e0141656},
  author       = {Hametner, Bernhard and Parragh, Stephanie and Mayer, Christopher and Weber, Thomas and Van Bortel, Lucas and De Buyzere, Marc and Segers, Patrick and Rietzschel, Ernst and Wassertheurer, Siegfried},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {NONINVASIVE EVALUATION,EXPERT CONSENSUS DOCUMENT,ARTERIAL STIFFNESS,AORTIC STIFFNESS,ORGAN DAMAGE,PRESSURE,AGE,HEALTHY,WOMEN,QUANTIFICATION},
  language     = {eng},
  number       = {10},
  pages        = {11},
  title        = {Assessment of model based (input) impedance, pulse wave velocity, and wave reflection in the Asklepios Cohort},
  url          = {http://dx.doi.org/10.1371/journal.pone.0141656},
  volume       = {10},
  year         = {2015},
}

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