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CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL

Stefano Arcangeli, Lidia Strigari, Guy Soete, Gert De Meerleer UGent, Sara Gomellini, VALERIE FONTEYNE UGent, Guy Storme and Giorgio Arcangeli (2009) INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 73(1). p.39-45
abstract
Purpose: To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer. Materials and Methods: Three institutions included 102 patients with TI-T3N0M0 prostate cancer in a Phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Acute toxicity was scored weekly during treatment and I and 2 months after treatment using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms and the International Prostate Symptom Index (IPSS). Correlation with a number of clinical and dosimetric parameters was assessed by univariate and multivariate analyses. Results: No Grade 3 or 4 GI side effects were observed. Grades I and 2 rectal GI toxicity occurred in 36%, and 38%, respectively. Corresponding figures for Grades 1 and 2 GU toxicity were 42% and 39%, respectively. Grade 3 or higher GU toxicity was detected in 4% of patients. In multivariate analysis, percent rectal volumes higher than 8% receiving doses >= 53 Gy (V-53) were statistically correlated to Grade 2 acute rectal reaction (p = 0.006). For GU morbidity, only the IPSS pretreatment score was independently associated (p = 0.0036) with an increase in GU acute effects. Conclusions: Acute GU and GI toxicity were comparable with other series. Our data show that increased incidence and intensity of acute toxicity is a transient effect related to shorter overall treatment time rather than a larger effect in biological equivalent dose with respect to a conventional fractionation regime.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Int. J. Radiat. Oncol. Biol. Phys.
volume
73
issue
1
pages
39 - 45
Web of Science type
Article
Web of Science id
000261820200008
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.592 (2009)
JCR rank
6/104 (2009)
JCR quartile
1 (2009)
ISSN
0360-3016
DOI
10.1016/j.ijrobp.2008.04.005
language
English
UGent publication?
yes
classification
A1
id
700649
handle
http://hdl.handle.net/1854/LU-700649
date created
2009-06-15 19:32:32
date last changed
2009-06-23 10:10:31
@article{700649,
  abstract     = {Purpose: To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer.

Materials and Methods: Three institutions included 102 patients with TI-T3N0M0 prostate cancer in a Phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Acute toxicity was scored weekly during treatment and I and 2 months after treatment using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms and the International Prostate Symptom Index (IPSS). Correlation with a number of clinical and dosimetric parameters was assessed by univariate and multivariate analyses.

Results: No Grade 3 or 4 GI side effects were observed. Grades I and 2 rectal GI toxicity occurred in 36\%, and 38\%, respectively. Corresponding figures for Grades 1 and 2 GU toxicity were 42\% and 39\%, respectively. Grade 3 or higher GU toxicity was detected in 4\% of patients. In multivariate analysis, percent rectal volumes higher than 8\% receiving doses {\textrangle}= 53 Gy (V-53) were statistically correlated to Grade 2 acute rectal reaction (p = 0.006). For GU morbidity, only the IPSS pretreatment score was independently associated (p = 0.0036) with an increase in GU acute effects.

Conclusions: Acute GU and GI toxicity were comparable with other series. Our data show that increased incidence and intensity of acute toxicity is a transient effect related to shorter overall treatment time rather than a larger effect in biological equivalent dose with respect to a conventional fractionation regime.},
  author       = {Arcangeli, Stefano and Strigari, Lidia and Soete, Guy and De Meerleer, Gert and Gomellini, Sara and FONTEYNE, VALERIE and Storme, Guy and Arcangeli, Giorgio},
  issn         = {0360-3016},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS},
  language     = {eng},
  number       = {1},
  pages        = {39--45},
  title        = {CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL},
  url          = {http://dx.doi.org/10.1016/j.ijrobp.2008.04.005},
  volume       = {73},
  year         = {2009},
}

Chicago
Arcangeli, Stefano, Lidia Strigari, Guy Soete, Gert De Meerleer, Sara Gomellini, Valérie Fonteyne, Guy Storme, and Giorgio Arcangeli. 2009. “CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL.” International Journal of Radiation Oncology Biology Physics 73 (1): 39–45.
APA
Arcangeli, S., Strigari, L., Soete, G., De Meerleer, G., Gomellini, S., Fonteyne, V., Storme, G., et al. (2009). CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 73(1), 39–45.
Vancouver
1.
Arcangeli S, Strigari L, Soete G, De Meerleer G, Gomellini S, Fonteyne V, et al. CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2009;73(1):39–45.
MLA
Arcangeli, Stefano, Lidia Strigari, Guy Soete, et al. “CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL.” INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 73.1 (2009): 39–45. Print.