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CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL

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Abstract
Purpose: To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer. Materials and Methods: Three institutions included 102 patients with TI-T3N0M0 prostate cancer in a Phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Acute toxicity was scored weekly during treatment and I and 2 months after treatment using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms and the International Prostate Symptom Index (IPSS). Correlation with a number of clinical and dosimetric parameters was assessed by univariate and multivariate analyses. Results: No Grade 3 or 4 GI side effects were observed. Grades I and 2 rectal GI toxicity occurred in 36%, and 38%, respectively. Corresponding figures for Grades 1 and 2 GU toxicity were 42% and 39%, respectively. Grade 3 or higher GU toxicity was detected in 4% of patients. In multivariate analysis, percent rectal volumes higher than 8% receiving doses >= 53 Gy (V-53) were statistically correlated to Grade 2 acute rectal reaction (p = 0.006). For GU morbidity, only the IPSS pretreatment score was independently associated (p = 0.0036) with an increase in GU acute effects. Conclusions: Acute GU and GI toxicity were comparable with other series. Our data show that increased incidence and intensity of acute toxicity is a transient effect related to shorter overall treatment time rather than a larger effect in biological equivalent dose with respect to a conventional fractionation regime.

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Chicago
Arcangeli, Stefano, Lidia Strigari, Guy Soete, Gert De Meerleer, Sara Gomellini, Valérie Fonteyne, Guy Storme, and Giorgio Arcangeli. 2009. “CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL.” International Journal of Radiation Oncology Biology Physics 73 (1): 39–45.
APA
Arcangeli, S., Strigari, L., Soete, G., De Meerleer, G., Gomellini, S., Fonteyne, V., Storme, G., et al. (2009). CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 73(1), 39–45.
Vancouver
1.
Arcangeli S, Strigari L, Soete G, De Meerleer G, Gomellini S, Fonteyne V, et al. CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2009;73(1):39–45.
MLA
Arcangeli, Stefano, Lidia Strigari, Guy Soete, et al. “CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL.” INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 73.1 (2009): 39–45. Print.
@article{700649,
  abstract     = {Purpose: To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer.

Materials and Methods: Three institutions included 102 patients with TI-T3N0M0 prostate cancer in a Phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Acute toxicity was scored weekly during treatment and I and 2 months after treatment using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms and the International Prostate Symptom Index (IPSS). Correlation with a number of clinical and dosimetric parameters was assessed by univariate and multivariate analyses.

Results: No Grade 3 or 4 GI side effects were observed. Grades I and 2 rectal GI toxicity occurred in 36\%, and 38\%, respectively. Corresponding figures for Grades 1 and 2 GU toxicity were 42\% and 39\%, respectively. Grade 3 or higher GU toxicity was detected in 4\% of patients. In multivariate analysis, percent rectal volumes higher than 8\% receiving doses {\textrangle}= 53 Gy (V-53) were statistically correlated to Grade 2 acute rectal reaction (p = 0.006). For GU morbidity, only the IPSS pretreatment score was independently associated (p = 0.0036) with an increase in GU acute effects.

Conclusions: Acute GU and GI toxicity were comparable with other series. Our data show that increased incidence and intensity of acute toxicity is a transient effect related to shorter overall treatment time rather than a larger effect in biological equivalent dose with respect to a conventional fractionation regime.},
  author       = {Arcangeli, Stefano and Strigari, Lidia and Soete, Guy and De Meerleer, Gert and Gomellini, Sara and FONTEYNE, VALERIE and Storme, Guy and Arcangeli, Giorgio},
  issn         = {0360-3016},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS},
  language     = {eng},
  number       = {1},
  pages        = {39--45},
  title        = {CLINICAL AND DOSIMETRIC PREDICTORS OF ACUTE TOXICITY AFTER A 4-WEEK HYPOFRACTIONATED EXTERNAL BEAM RADIOTHERAPY REGIMEN FOR PROSTATE CANCER: RESULTS FROM A MULTICENTRIC PROSPECTIVE TRIAL},
  url          = {http://dx.doi.org/10.1016/j.ijrobp.2008.04.005},
  volume       = {73},
  year         = {2009},
}

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