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INTENSITY-MODULATED RADIOTHERAPY FOR SINONASAL TUMORS: GHENT UNIVERSITY HOSPITAL UPDATE

Indira Madani UGent, KATRIEN BONTE UGent, Luc Vakaet UGent, Tom Boterberg UGent and Wilfried De Neve UGent (2009) INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 73(2). p.424-432
abstract
Purpose: To report the long-term outcome of intensity-modulated radiotherapy (IMRT) for sinonasal tumors. Methods and Materials: Between July 1998 and November 2006, 84 patients with sinonasal tumors were treated with IMRT to a median dose of 70 Gy in 35 fractions. Of the 84 patients, 73 had a primary tumor and 11 had local recurrence. The tumor histologic type was adenocarcinoma in 54, squamous; cell carcinoma in 17, esthesioneuroblastoma in 9, and adenoid cystic carcinoma in 4. The tumors were located in the ethmoid sinus in 47, maxillary sinus in 19, nasal cavity in 16, and multiple sites in 2. Postoperative IMRT was performed in 75 patients and 9 patients received primary IMRT. Results: The median follow-up of living patients was 40 months (range, 8-106). The 5-year local control, overall survival, disease-specific survival, disease-free survival, and freedom from distant metastasis rate was 70.7%, 58.5%, 67%, 59.3%, and 82.2%, respectively. No difference was found in local control and survival between patients with primary or recurrent tumors. On multivariate analysis, invasion of the cribriform plate was significantly associated with lower local control (p = 0.0001) and overall survival (p = 0.0001). Local and distant recurrence was detected in 19 and 10 patients, respectively. Radiation-induced blindness was not observed. One patient developed Grade 3 radiation-induced retinopathy and neovascular glaucoma. Nonocular late radiation-induced toxicity comprised complete lacrimal duct stenosis in 1 patient and brain necrosis in 3 patients. Osteoradionecrosis of the maxilla and brain necrosis were detected in 1 of the 5 reirradiated patients. Conclusion: IMRT for sinonasal tumors provides low rates of radiation-induced toxicity without blindness with high local control and survival. IMRT could be considered as the treatment of choice.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Int. J. Radiat. Oncol. Biol. Phys.
volume
73
issue
2
pages
424 - 432
Web of Science type
Article
Web of Science id
000262543800016
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.592 (2009)
JCR rank
6/104 (2009)
JCR quartile
1 (2009)
ISSN
0360-3016
DOI
10.1016/j.ijrobp.2008.04.037
language
English
UGent publication?
yes
classification
A1
id
700587
handle
http://hdl.handle.net/1854/LU-700587
date created
2009-06-15 19:25:10
date last changed
2009-06-23 09:59:09
@article{700587,
  abstract     = {Purpose: To report the long-term outcome of intensity-modulated radiotherapy (IMRT) for sinonasal tumors.

Methods and Materials: Between July 1998 and November 2006, 84 patients with sinonasal tumors were treated with IMRT to a median dose of 70 Gy in 35 fractions. Of the 84 patients, 73 had a primary tumor and 11 had local recurrence. The tumor histologic type was adenocarcinoma in 54, squamous; cell carcinoma in 17, esthesioneuroblastoma in 9, and adenoid cystic carcinoma in 4. The tumors were located in the ethmoid sinus in 47, maxillary sinus in 19, nasal cavity in 16, and multiple sites in 2. Postoperative IMRT was performed in 75 patients and 9 patients received primary IMRT.

Results: The median follow-up of living patients was 40 months (range, 8-106). The 5-year local control, overall survival, disease-specific survival, disease-free survival, and freedom from distant metastasis rate was 70.7\%, 58.5\%, 67\%, 59.3\%, and 82.2\%, respectively. No difference was found in local control and survival between patients with primary or recurrent tumors. On multivariate analysis, invasion of the cribriform plate was significantly associated with lower local control (p = 0.0001) and overall survival (p = 0.0001). Local and distant recurrence was detected in 19 and 10 patients, respectively. Radiation-induced blindness was not observed. One patient developed Grade 3 radiation-induced retinopathy and neovascular glaucoma. Nonocular late radiation-induced toxicity comprised complete lacrimal duct stenosis in 1 patient and brain necrosis in 3 patients. Osteoradionecrosis of the maxilla and brain necrosis were detected in 1 of the 5 reirradiated patients.

Conclusion: IMRT for sinonasal tumors provides low rates of radiation-induced toxicity without blindness with high local control and survival. IMRT could be considered as the treatment of choice.},
  author       = {Madani, Indira and BONTE, KATRIEN and Vakaet, Luc and Boterberg, Tom and De Neve, Wilfried},
  issn         = {0360-3016},
  journal      = {INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS},
  language     = {eng},
  number       = {2},
  pages        = {424--432},
  title        = {INTENSITY-MODULATED RADIOTHERAPY FOR SINONASAL TUMORS: GHENT UNIVERSITY HOSPITAL UPDATE},
  url          = {http://dx.doi.org/10.1016/j.ijrobp.2008.04.037},
  volume       = {73},
  year         = {2009},
}

Chicago
Madani, Indira, KATRIEN BONTE, Luc Vakaet, Tom Boterberg, and Wilfried De Neve. 2009. “Intensity-modulated Radiotherapy for Sinonasal Tumors: Ghent University Hospital Update.” International Journal of Radiation Oncology Biology Physics 73 (2): 424–432.
APA
Madani, I., BONTE, K., Vakaet, L., Boterberg, T., & De Neve, W. (2009). INTENSITY-MODULATED RADIOTHERAPY FOR SINONASAL TUMORS: GHENT UNIVERSITY HOSPITAL UPDATE. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 73(2), 424–432.
Vancouver
1.
Madani I, BONTE K, Vakaet L, Boterberg T, De Neve W. INTENSITY-MODULATED RADIOTHERAPY FOR SINONASAL TUMORS: GHENT UNIVERSITY HOSPITAL UPDATE. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2009;73(2):424–32.
MLA
Madani, Indira, KATRIEN BONTE, Luc Vakaet, et al. “Intensity-modulated Radiotherapy for Sinonasal Tumors: Ghent University Hospital Update.” INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 73.2 (2009): 424–432. Print.