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Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells

Ariane De Ganck UGent, VEERLE DE CORTE UGent, Erik Bruyneel, Marc Bracke UGent, Joël Vandekerckhove UGent and Jan Gettemans UGent (2009) INTERNATIONAL JOURNAL OF ONCOLOGY. 34(5). p.1403-1409
abstract
Enhanced motility of cancer cells by remodelling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. Although several studies propose a tumor suppressor role for the actin bundling protein myopodin, it was also shown previously that overexpression of mouse myopodin promotes invasion in vitro. In the present study, the role of myopodin in human cancer cell motility and invasion was explored using RNA interference with siRNA duplexes designed to down-regulate all human myopodin isoforms currently identified. We show that down-regulation of myopodin expression in human cancer cells significantly reduces the invasive properties of these cells both in collagen type I and in Matrigel (R). Furthermore, the motile characteristics of cancer cells are also curbed by reduced myopodin expression whereas cell-cell contacts are reinforced. These results point to a role for myopodin as tumor activator. While these findings are at variance with the suggested tumor suppressor role for myopodin, we hypothesize that the subcellular localization of the protein is involved in its suppressor or activator function in tumorigenesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
Int. J. Oncol.
volume
34
issue
5
pages
1403 - 1409
Web of Science type
Article
Web of Science id
000265261200024
JCR category
ONCOLOGY
JCR impact factor
2.447 (2009)
JCR rank
82/163 (2009)
JCR quartile
3 (2009)
ISSN
1019-6439
DOI
10.3892/ijo_00000268
language
English
UGent publication?
yes
classification
A1
id
700329
handle
http://hdl.handle.net/1854/LU-700329
date created
2009-06-15 16:42:28
date last changed
2013-01-30 09:41:41
@article{700329,
  abstract     = {Enhanced motility of cancer cells by remodelling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. Although several studies propose a tumor suppressor role for the actin bundling protein myopodin, it was also shown previously that overexpression of mouse myopodin promotes invasion in vitro. In the present study, the role of myopodin in human cancer cell motility and invasion was explored using RNA interference with siRNA duplexes designed to down-regulate all human myopodin isoforms currently identified. We show that down-regulation of myopodin expression in human cancer cells significantly reduces the invasive properties of these cells both in collagen type I and in Matrigel (R). Furthermore, the motile characteristics of cancer cells are also curbed by reduced myopodin expression whereas cell-cell contacts are reinforced. These results point to a role for myopodin as tumor activator. While these findings are at variance with the suggested tumor suppressor role for myopodin, we hypothesize that the subcellular localization of the protein is involved in its suppressor or activator function in tumorigenesis.},
  author       = {De Ganck, Ariane and DE CORTE, VEERLE and Bruyneel, Erik and Bracke, Marc and Vandekerckhove, Jo{\"e}l and Gettemans, Jan},
  issn         = {1019-6439},
  journal      = {INTERNATIONAL JOURNAL OF ONCOLOGY},
  language     = {eng},
  number       = {5},
  pages        = {1403--1409},
  title        = {Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells},
  url          = {http://dx.doi.org/10.3892/ijo\_00000268},
  volume       = {34},
  year         = {2009},
}

Chicago
De Ganck, Ariane, VEERLE DE CORTE, Erik Bruyneel, Marc Bracke, Joël Vandekerckhove, and Jan Gettemans. 2009. “Down-regulation of Myopodin Expression Reduces Invasion and Motility of PC-3 Prostate Cancer Cells.” International Journal of Oncology 34 (5): 1403–1409.
APA
De Ganck, A., DE CORTE, V., Bruyneel, E., Bracke, M., Vandekerckhove, J., & Gettemans, J. (2009). Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY, 34(5), 1403–1409.
Vancouver
1.
De Ganck A, DE CORTE V, Bruyneel E, Bracke M, Vandekerckhove J, Gettemans J. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY. 2009;34(5):1403–9.
MLA
De Ganck, Ariane, VEERLE DE CORTE, Erik Bruyneel, et al. “Down-regulation of Myopodin Expression Reduces Invasion and Motility of PC-3 Prostate Cancer Cells.” INTERNATIONAL JOURNAL OF ONCOLOGY 34.5 (2009): 1403–1409. Print.