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Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium : results from the BIO-HF registry

(2015) ACTA CARDIOLOGICA. 70(4). p.375-385
Author
Organization
Abstract
Aims: Hospitalization for acute decompensated heart failure (HF) is associated with poor outcome. As specific data for Belgium are currently not available, the aim of the Belgian BIO-HF registry is to evaluate the clinical characteristics, in-hospital mortality and outcomes after discharge of patients hospitalized for acute HF. Methods and results: This is a prospective observational cohort study conducted in 2 Belgian hospitals. For the current analysis, the first 904 patients who were enrolled between 2008 and 2012 were selected for assessment of clinical characteristics and short-term outcome (all-cause mortality and all-cause mortality + rehospitalization 3 months after discharge). Mean age of patients was 77 years (51% >= 80 years), 44% were women and 64% had an eGFR <60 ml/min/m(2). Mean LVEF was 42% with only 40% with LVEF <= 35%, 20% with LVEF between 36 and 49% and 40% with LVEF >= 50%. In-hospital mortality was 7.1% with a mortality of 22% in the subgroup of patients with a creatinine >= 2 mg/dl and systolic blood pressure <= 110 mmHg on admission. Three months after discharge, the all-cause mortality rate was 7.6% and the all-cause mortality or hospitalization for HF 18.3%. Multivariate Cox regression analysis revealed eGFR, COPD, absence of beta blockers and atrial fibrillation at discharge (all P < 0.05)as independent predictors of all-cause mortality. Conclusions: In this Belgian registry of mainly elderly patients admitted with acute HF, a relatively preserved EF and a reduced kidney function were present in the majority of patients. In-hospital and short-term mortality after discharge remain high and are mainly related to the presence of co-morbidities such as renal failure and COPD. Co-morbidities should be the focus for future efforts to improve the dire outcome of these patients.
Keywords
outcome, Clinical characteristics, heart failure, hospitalization, OBSTRUCTIVE PULMONARY-DISEASE, EJECTION FRACTION, EUROPEAN-SOCIETY, OPTIMIZE-HF, MORTALITY, COEXISTENT, IMPACT, ESC, HOSPITALIZATIONS, ASSOCIATION

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MLA
De Sutter, Johan, et al. “Clinical Characteristics and Short-Term Outcome of Patients Admitted with Heart Failure in Belgium : Results from the BIO-HF Registry.” ACTA CARDIOLOGICA, vol. 70, no. 4, 2015, pp. 375–85, doi:10.2143/AC.70.4.3094645.
APA
De Sutter, J., Pardaens, S., Audenaert, T., Weytjens, C., Vande Kerckhove, B., Willems, A.-M., … Van Camp, G. (2015). Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium : results from the BIO-HF registry. ACTA CARDIOLOGICA, 70(4), 375–385. https://doi.org/10.2143/AC.70.4.3094645
Chicago author-date
De Sutter, Johan, Sofie Pardaens, Tjorven Audenaert, Caroline Weytjens, Barbara Vande Kerckhove, Anne-Marie Willems, Nancy De Laet, and Guy Van Camp. 2015. “Clinical Characteristics and Short-Term Outcome of Patients Admitted with Heart Failure in Belgium : Results from the BIO-HF Registry.” ACTA CARDIOLOGICA 70 (4): 375–85. https://doi.org/10.2143/AC.70.4.3094645.
Chicago author-date (all authors)
De Sutter, Johan, Sofie Pardaens, Tjorven Audenaert, Caroline Weytjens, Barbara Vande Kerckhove, Anne-Marie Willems, Nancy De Laet, and Guy Van Camp. 2015. “Clinical Characteristics and Short-Term Outcome of Patients Admitted with Heart Failure in Belgium : Results from the BIO-HF Registry.” ACTA CARDIOLOGICA 70 (4): 375–385. doi:10.2143/AC.70.4.3094645.
Vancouver
1.
De Sutter J, Pardaens S, Audenaert T, Weytjens C, Vande Kerckhove B, Willems A-M, et al. Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium : results from the BIO-HF registry. ACTA CARDIOLOGICA. 2015;70(4):375–85.
IEEE
[1]
J. De Sutter et al., “Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium : results from the BIO-HF registry,” ACTA CARDIOLOGICA, vol. 70, no. 4, pp. 375–385, 2015.
@article{6999163,
  abstract     = {{Aims: Hospitalization for acute decompensated heart failure (HF) is associated with poor outcome. As specific data for Belgium are currently not available, the aim of the Belgian BIO-HF registry is to evaluate the clinical characteristics, in-hospital mortality and outcomes after discharge of patients hospitalized for acute HF. 
Methods and results: This is a prospective observational cohort study conducted in 2 Belgian hospitals. For the current analysis, the first 904 patients who were enrolled between 2008 and 2012 were selected for assessment of clinical characteristics and short-term outcome (all-cause mortality and all-cause mortality + rehospitalization 3 months after discharge). Mean age of patients was 77 years (51% >= 80 years), 44% were women and 64% had an eGFR <60 ml/min/m(2). Mean LVEF was 42% with only 40% with LVEF <= 35%, 20% with LVEF between 36 and 49% and 40% with LVEF >= 50%. In-hospital mortality was 7.1% with a mortality of 22% in the subgroup of patients with a creatinine >= 2 mg/dl and systolic blood pressure <= 110 mmHg on admission. Three months after discharge, the all-cause mortality rate was 7.6% and the all-cause mortality or hospitalization for HF 18.3%. Multivariate Cox regression analysis revealed eGFR, COPD, absence of beta blockers and atrial fibrillation at discharge (all P < 0.05)as independent predictors of all-cause mortality. 
Conclusions: In this Belgian registry of mainly elderly patients admitted with acute HF, a relatively preserved EF and a reduced kidney function were present in the majority of patients. In-hospital and short-term mortality after discharge remain high and are mainly related to the presence of co-morbidities such as renal failure and COPD. Co-morbidities should be the focus for future efforts to improve the dire outcome of these patients.}},
  author       = {{De Sutter, Johan and Pardaens, Sofie and Audenaert, Tjorven and Weytjens, Caroline and Vande Kerckhove, Barbara and Willems, Anne-Marie and De Laet, Nancy and Van Camp, Guy}},
  issn         = {{0001-5385}},
  journal      = {{ACTA CARDIOLOGICA}},
  keywords     = {{outcome,Clinical characteristics,heart failure,hospitalization,OBSTRUCTIVE PULMONARY-DISEASE,EJECTION FRACTION,EUROPEAN-SOCIETY,OPTIMIZE-HF,MORTALITY,COEXISTENT,IMPACT,ESC,HOSPITALIZATIONS,ASSOCIATION}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{375--385}},
  title        = {{Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium : results from the BIO-HF registry}},
  url          = {{http://doi.org/10.2143/AC.70.4.3094645}},
  volume       = {{70}},
  year         = {{2015}},
}

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