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Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium: results from the BIO-HF registry

Johan De Sutter UGent, Sofie Pardaens UGent, Tjorven Audenaert, Caroline Weytjens, Barbara Vande Kerckhove, Anne-Marie Willems, Nancy De Laet and Guy Van Camp (2015) ACTA CARDIOLOGICA. 70(4). p.375-385
abstract
Aims: Hospitalization for acute decompensated heart failure (HF) is associated with poor outcome. As specific data for Belgium are currently not available, the aim of the Belgian BIO-HF registry is to evaluate the clinical characteristics, in-hospital mortality and outcomes after discharge of patients hospitalized for acute HF. Methods and results: This is a prospective observational cohort study conducted in 2 Belgian hospitals. For the current analysis, the first 904 patients who were enrolled between 2008 and 2012 were selected for assessment of clinical characteristics and short-term outcome (all-cause mortality and all-cause mortality + rehospitalization 3 months after discharge). Mean age of patients was 77 years (51% >= 80 years), 44% were women and 64% had an eGFR <60 ml/min/m(2). Mean LVEF was 42% with only 40% with LVEF <= 35%, 20% with LVEF between 36 and 49% and 40% with LVEF >= 50%. In-hospital mortality was 7.1% with a mortality of 22% in the subgroup of patients with a creatinine >= 2 mg/dl and systolic blood pressure <= 110 mmHg on admission. Three months after discharge, the all-cause mortality rate was 7.6% and the all-cause mortality or hospitalization for HF 18.3%. Multivariate Cox regression analysis revealed eGFR, COPD, absence of beta blockers and atrial fibrillation at discharge (all P < 0.05)as independent predictors of all-cause mortality. Conclusions: In this Belgian registry of mainly elderly patients admitted with acute HF, a relatively preserved EF and a reduced kidney function were present in the majority of patients. In-hospital and short-term mortality after discharge remain high and are mainly related to the presence of co-morbidities such as renal failure and COPD. Co-morbidities should be the focus for future efforts to improve the dire outcome of these patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
outcome, Clinical characteristics, heart failure, hospitalization, OBSTRUCTIVE PULMONARY-DISEASE, EJECTION FRACTION, EUROPEAN-SOCIETY, OPTIMIZE-HF, MORTALITY, COEXISTENT, IMPACT, ESC, HOSPITALIZATIONS, ASSOCIATION
journal title
ACTA CARDIOLOGICA
Acta Cardiol.
volume
70
issue
4
pages
375 - 385
Web of Science type
Article
Web of Science id
000360326200001
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
0.6 (2015)
JCR rank
118/124 (2015)
JCR quartile
4 (2015)
ISSN
0001-5385
DOI
10.2143/AC.70.4.3094645
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6999163
handle
http://hdl.handle.net/1854/LU-6999163
date created
2015-12-02 10:16:24
date last changed
2016-12-19 15:46:55
@article{6999163,
  abstract     = {Aims: Hospitalization for acute decompensated heart failure (HF) is associated with poor outcome. As specific data for Belgium are currently not available, the aim of the Belgian BIO-HF registry is to evaluate the clinical characteristics, in-hospital mortality and outcomes after discharge of patients hospitalized for acute HF. 
Methods and results: This is a prospective observational cohort study conducted in 2 Belgian hospitals. For the current analysis, the first 904 patients who were enrolled between 2008 and 2012 were selected for assessment of clinical characteristics and short-term outcome (all-cause mortality and all-cause mortality + rehospitalization 3 months after discharge). Mean age of patients was 77 years (51\% {\textrangle}= 80 years), 44\% were women and 64\% had an eGFR {\textlangle}60 ml/min/m(2). Mean LVEF was 42\% with only 40\% with LVEF {\textlangle}= 35\%, 20\% with LVEF between 36 and 49\% and 40\% with LVEF {\textrangle}= 50\%. In-hospital mortality was 7.1\% with a mortality of 22\% in the subgroup of patients with a creatinine {\textrangle}= 2 mg/dl and systolic blood pressure {\textlangle}= 110 mmHg on admission. Three months after discharge, the all-cause mortality rate was 7.6\% and the all-cause mortality or hospitalization for HF 18.3\%. Multivariate Cox regression analysis revealed eGFR, COPD, absence of beta blockers and atrial fibrillation at discharge (all P {\textlangle} 0.05)as independent predictors of all-cause mortality. 
Conclusions: In this Belgian registry of mainly elderly patients admitted with acute HF, a relatively preserved EF and a reduced kidney function were present in the majority of patients. In-hospital and short-term mortality after discharge remain high and are mainly related to the presence of co-morbidities such as renal failure and COPD. Co-morbidities should be the focus for future efforts to improve the dire outcome of these patients.},
  author       = {De Sutter, Johan and Pardaens, Sofie and Audenaert, Tjorven and Weytjens, Caroline and Vande Kerckhove, Barbara and Willems, Anne-Marie and De Laet, Nancy and Van Camp, Guy},
  issn         = {0001-5385},
  journal      = {ACTA CARDIOLOGICA},
  keyword      = {outcome,Clinical characteristics,heart failure,hospitalization,OBSTRUCTIVE PULMONARY-DISEASE,EJECTION FRACTION,EUROPEAN-SOCIETY,OPTIMIZE-HF,MORTALITY,COEXISTENT,IMPACT,ESC,HOSPITALIZATIONS,ASSOCIATION},
  language     = {eng},
  number       = {4},
  pages        = {375--385},
  title        = {Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium: results from the BIO-HF registry},
  url          = {http://dx.doi.org/10.2143/AC.70.4.3094645},
  volume       = {70},
  year         = {2015},
}

Chicago
De Sutter, Johan, Sofie Pardaens, Tjorven Audenaert, Caroline Weytjens, Barbara Vande Kerckhove, Anne-Marie Willems, Nancy De Laet, and Guy Van Camp. 2015. “Clinical Characteristics and Short-term Outcome of Patients Admitted with Heart Failure in Belgium: Results from the BIO-HF Registry.” Acta Cardiologica 70 (4): 375–385.
APA
De Sutter, J., Pardaens, S., Audenaert, T., Weytjens, C., Vande Kerckhove, B., Willems, A.-M., De Laet, N., et al. (2015). Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium: results from the BIO-HF registry. ACTA CARDIOLOGICA, 70(4), 375–385.
Vancouver
1.
De Sutter J, Pardaens S, Audenaert T, Weytjens C, Vande Kerckhove B, Willems A-M, et al. Clinical characteristics and short-term outcome of patients admitted with heart failure in Belgium: results from the BIO-HF registry. ACTA CARDIOLOGICA. 2015;70(4):375–85.
MLA
De Sutter, Johan, Sofie Pardaens, Tjorven Audenaert, et al. “Clinical Characteristics and Short-term Outcome of Patients Admitted with Heart Failure in Belgium: Results from the BIO-HF Registry.” ACTA CARDIOLOGICA 70.4 (2015): 375–385. Print.