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No effect of insecticide treated curtain deployment on Aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba

Maria Eugenia Toledo, Veerle Vanlerberghe, Isora Lambert, Domingo Montada, Alberto Baly and Patrick Van Der Stuyft UGent (2015) PLOS ONE. 10(3).
abstract
Objective & Methodology : The current study evaluated the effectiveness and cost-effectiveness of Insecticide Treated Curtain (ITC) deployment for reducing dengue vector infestation levels in the Cuban context with intensive routine control activities. A cluster randomized controlled trial took place in Guantanamo city, east Cuba. Twelve neighborhoods (about 500 households each) were selected among the ones with the highest Aedes infestation levels in the previous two years, and were randomly allocated to the intervention and control arms. Long lasting ITC (PermaNet) were distributed in the intervention clusters in March 2009. Routine control activities were continued in the whole study area. In both study arms, we monitored monthly pre-and post-intervention House Index (HI, number of houses with at least 1 container with Aedes immature stages/100 houses inspected), during 12 and 18 months respectively. We evaluated the effect of ITC deployment on HI by fitting a generalized linear regression model with a negative binomial link function to these data. Principal Findings : At distribution, the ITC coverage (% of households using >= 1 ITC) reached 98.4%, with a median of 3 ITC distributed/household. After 18 months, the coverage remained 97.4%. The local Aedes species was susceptible to deltamethrin (mosquito mortality rate of 99.7%) and the residual deltamethrin activity in the ITC was within acceptable levels (mosquito mortality rate of 73.1%) after one year of curtain use. Over the 18 month observation period after ITC distribution, the adjusted HI rate ratio, intervention versus control clusters, was 1.15 (95% CI 0.57 to 2.34). The annualized cost per household of ITC implementation was 3.8 USD, against 16.8 USD for all routine ACP activities. Conclusion : Deployment of ITC in a setting with already intensive routine Aedes control actions does not lead to reductions in Aedes infestation levels.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
THAILAND, AEGYPTI CONTROL, COST, VECTOR CONTROL, PREVENTION, EPIDEMIC, LESSONS
journal title
PLOS ONE
PLoS One
volume
10
issue
3
article number
e0119373
pages
12 pages
Web of Science type
Article
Web of Science id
000352084200076
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
3.057 (2015)
JCR rank
11/63 (2015)
JCR quartile
1 (2015)
ISSN
1932-6203
DOI
10.1371/journal.pone.0119373
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
6997598
handle
http://hdl.handle.net/1854/LU-6997598
date created
2015-12-01 11:30:53
date last changed
2016-12-21 15:41:52
@article{6997598,
  abstract     = {Objective \& Methodology : The current study evaluated the effectiveness and cost-effectiveness of Insecticide Treated Curtain (ITC) deployment for reducing dengue vector infestation levels in the Cuban context with intensive routine control activities. A cluster randomized controlled trial took place in Guantanamo city, east Cuba. Twelve neighborhoods (about 500 households each) were selected among the ones with the highest Aedes infestation levels in the previous two years, and were randomly allocated to the intervention and control arms. Long lasting ITC (PermaNet) were distributed in the intervention clusters in March 2009. Routine control activities were continued in the whole study area. In both study arms, we monitored monthly pre-and post-intervention House Index (HI, number of houses with at least 1 container with Aedes immature stages/100 houses inspected), during 12 and 18 months respectively. We evaluated the effect of ITC deployment on HI by fitting a generalized linear regression model with a negative binomial link function to these data. 
Principal Findings : At distribution, the ITC coverage (\% of households using {\textrangle}= 1 ITC) reached 98.4\%, with a median of 3 ITC distributed/household. After 18 months, the coverage remained 97.4\%. The local Aedes species was susceptible to deltamethrin (mosquito mortality rate of 99.7\%) and the residual deltamethrin activity in the ITC was within acceptable levels (mosquito mortality rate of 73.1\%) after one year of curtain use. Over the 18 month observation period after ITC distribution, the adjusted HI rate ratio, intervention versus control clusters, was 1.15 (95\% CI 0.57 to 2.34). The annualized cost per household of ITC implementation was 3.8 USD, against 16.8 USD for all routine ACP activities. 
Conclusion : Deployment of ITC in a setting with already intensive routine Aedes control actions does not lead to reductions in Aedes infestation levels.},
  articleno    = {e0119373},
  author       = {Toledo, Maria Eugenia and Vanlerberghe, Veerle and Lambert, Isora and Montada, Domingo and Baly, Alberto and Van Der Stuyft, Patrick},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {THAILAND,AEGYPTI CONTROL,COST,VECTOR CONTROL,PREVENTION,EPIDEMIC,LESSONS},
  language     = {eng},
  number       = {3},
  pages        = {12},
  title        = {No effect of insecticide treated curtain deployment on Aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba},
  url          = {http://dx.doi.org/10.1371/journal.pone.0119373},
  volume       = {10},
  year         = {2015},
}

Chicago
Toledo, Maria Eugenia, Veerle Vanlerberghe, Isora Lambert, Domingo Montada, Alberto Baly, and Patrick Van Der Stuyft. 2015. “No Effect of Insecticide Treated Curtain Deployment on Aedes Infestation in a Cluster Randomized Trial in a Setting of Low Dengue Transmission in Guantanamo, Cuba.” Plos One 10 (3).
APA
Toledo, Maria Eugenia, Vanlerberghe, V., Lambert, I., Montada, D., Baly, A., & Van Der Stuyft, P. (2015). No effect of insecticide treated curtain deployment on Aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba. PLOS ONE, 10(3).
Vancouver
1.
Toledo ME, Vanlerberghe V, Lambert I, Montada D, Baly A, Van Der Stuyft P. No effect of insecticide treated curtain deployment on Aedes infestation in a cluster randomized trial in a setting of low dengue transmission in Guantanamo, Cuba. PLOS ONE. 2015;10(3).
MLA
Toledo, Maria Eugenia, Veerle Vanlerberghe, Isora Lambert, et al. “No Effect of Insecticide Treated Curtain Deployment on Aedes Infestation in a Cluster Randomized Trial in a Setting of Low Dengue Transmission in Guantanamo, Cuba.” PLOS ONE 10.3 (2015): n. pag. Print.