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Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru

Brian Lackey, Carlos Seas, Patrick Van Der Stuyft UGent and Larissa Otero (2015) PLOS ONE. 10(6).
abstract
Background : Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be associated with poor adherence, but this problem remains a substantial barrier to global TB control. We studied patients in a high-incidence district of Lima, Peru to identify factors associated with premature termination of treatment (treatment default). Methods : We conducted a prospective cohort study of adult smear-positive TB patients enrolled between January 2010 and December 2011 with no history of TB disease. Descriptive statistics and multivariable logistic regression analyses were performed to determine risk factors associated with treatment default. Results : Of the 1233 patients studied, 127 (10%) defaulted from treatment. Patients who defaulted were more likely to have used illegal drugs (OR = 4.78, 95% CI: 3.05-7.49), have multidrug-resistant TB (OR = 3.04, 95% CI: 1.58-5.85), not have been tested for HIV (OR = 2.30, 95% CI: 1.50-3.54), drink alcohol at least weekly (OR = 2.22, 95% CI: 1.40-3.52), be underweight (OR = 2.08, 95% CI: 1.21-3.56), or not have completed secondary education (OR = 1.55, 95% CI: 1.03-2.33). Conclusions : Our study identified several factors associated with defaulting from treatment, suggesting a complex set of causes that might lead to default. Addressing these factors individually would be difficult, but they might help to identify certain high-risk patients for supplemental
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MULTIDRUG-RESISTANT TUBERCULOSIS, RISK-FACTORS, ADHERENCE, PREDICTORS, STRATEGIES, 5-YEAR
journal title
PLOS ONE
PLoS One
volume
10
issue
6
article number
e0128541
pages
11 pages
Web of Science type
Article
Web of Science id
000355652200076
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
3.057 (2015)
JCR rank
11/63 (2015)
JCR quartile
1 (2015)
ISSN
1932-6203
DOI
10.1371/journal.pone.0128541
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
6997574
handle
http://hdl.handle.net/1854/LU-6997574
date created
2015-12-01 11:30:53
date last changed
2017-04-19 12:19:53
@article{6997574,
  abstract     = {Background : Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be associated with poor adherence, but this problem remains a substantial barrier to global TB control. We studied patients in a high-incidence district of Lima, Peru to identify factors associated with premature termination of treatment (treatment default). 
Methods : We conducted a prospective cohort study of adult smear-positive TB patients enrolled between January 2010 and December 2011 with no history of TB disease. Descriptive statistics and multivariable logistic regression analyses were performed to determine risk factors associated with treatment default. 
Results : Of the 1233 patients studied, 127 (10\%) defaulted from treatment. Patients who defaulted were more likely to have used illegal drugs (OR = 4.78, 95\% CI: 3.05-7.49), have multidrug-resistant TB (OR = 3.04, 95\% CI: 1.58-5.85), not have been tested for HIV (OR = 2.30, 95\% CI: 1.50-3.54), drink alcohol at least weekly (OR = 2.22, 95\% CI: 1.40-3.52), be underweight (OR = 2.08, 95\% CI: 1.21-3.56), or not have completed secondary education (OR = 1.55, 95\% CI: 1.03-2.33). 
Conclusions : Our study identified several factors associated with defaulting from treatment, suggesting a complex set of causes that might lead to default. Addressing these factors individually would be difficult, but they might help to identify certain high-risk patients for supplemental},
  articleno    = {e0128541},
  author       = {Lackey, Brian and Seas, Carlos and Van Der Stuyft, Patrick and Otero, Larissa},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {MULTIDRUG-RESISTANT TUBERCULOSIS,RISK-FACTORS,ADHERENCE,PREDICTORS,STRATEGIES,5-YEAR},
  language     = {eng},
  number       = {6},
  pages        = {11},
  title        = {Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru},
  url          = {http://dx.doi.org/10.1371/journal.pone.0128541},
  volume       = {10},
  year         = {2015},
}

Chicago
Lackey, Brian, Carlos Seas, Patrick Van Der Stuyft, and Larissa Otero. 2015. “Patient Characteristics Associated with Tuberculosis Treatment Default: a Cohort Study in a High-incidence Area of Lima, Peru.” Plos One 10 (6).
APA
Lackey, B., Seas, C., Van Der Stuyft, P., & Otero, L. (2015). Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru. PLOS ONE, 10(6).
Vancouver
1.
Lackey B, Seas C, Van Der Stuyft P, Otero L. Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru. PLOS ONE. 2015;10(6).
MLA
Lackey, Brian, Carlos Seas, Patrick Van Der Stuyft, et al. “Patient Characteristics Associated with Tuberculosis Treatment Default: a Cohort Study in a High-incidence Area of Lima, Peru.” PLOS ONE 10.6 (2015): n. pag. Print.