Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru
(2015) PLOS ONE. 10(6).- abstract
- Background : Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be associated with poor adherence, but this problem remains a substantial barrier to global TB control. We studied patients in a high-incidence district of Lima, Peru to identify factors associated with premature termination of treatment (treatment default). Methods : We conducted a prospective cohort study of adult smear-positive TB patients enrolled between January 2010 and December 2011 with no history of TB disease. Descriptive statistics and multivariable logistic regression analyses were performed to determine risk factors associated with treatment default. Results : Of the 1233 patients studied, 127 (10%) defaulted from treatment. Patients who defaulted were more likely to have used illegal drugs (OR = 4.78, 95% CI: 3.05-7.49), have multidrug-resistant TB (OR = 3.04, 95% CI: 1.58-5.85), not have been tested for HIV (OR = 2.30, 95% CI: 1.50-3.54), drink alcohol at least weekly (OR = 2.22, 95% CI: 1.40-3.52), be underweight (OR = 2.08, 95% CI: 1.21-3.56), or not have completed secondary education (OR = 1.55, 95% CI: 1.03-2.33). Conclusions : Our study identified several factors associated with defaulting from treatment, suggesting a complex set of causes that might lead to default. Addressing these factors individually would be difficult, but they might help to identify certain high-risk patients for supplemental
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-6997574
- author
- Brian Lackey, Carlos Seas, Patrick Van Der Stuyft UGent and Larissa Otero
- organization
- year
- 2015
- type
- journalArticle (original)
- publication status
- published
- subject
- keyword
- MULTIDRUG-RESISTANT TUBERCULOSIS, RISK-FACTORS, ADHERENCE, PREDICTORS, STRATEGIES, 5-YEAR
- journal title
- PLOS ONE
- PLoS One
- volume
- 10
- issue
- 6
- article number
- e0128541
- pages
- 11 pages
- Web of Science type
- Article
- Web of Science id
- 000355652200076
- JCR category
- MULTIDISCIPLINARY SCIENCES
- JCR impact factor
- 3.057 (2015)
- JCR rank
- 11/63 (2015)
- JCR quartile
- 1 (2015)
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0128541
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have retained and own the full copyright for this publication
- id
- 6997574
- handle
- http://hdl.handle.net/1854/LU-6997574
- date created
- 2015-12-01 11:30:53
- date last changed
- 2017-04-19 12:19:53
@article{6997574, abstract = {Background : Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be associated with poor adherence, but this problem remains a substantial barrier to global TB control. We studied patients in a high-incidence district of Lima, Peru to identify factors associated with premature termination of treatment (treatment default). Methods : We conducted a prospective cohort study of adult smear-positive TB patients enrolled between January 2010 and December 2011 with no history of TB disease. Descriptive statistics and multivariable logistic regression analyses were performed to determine risk factors associated with treatment default. Results : Of the 1233 patients studied, 127 (10\%) defaulted from treatment. Patients who defaulted were more likely to have used illegal drugs (OR = 4.78, 95\% CI: 3.05-7.49), have multidrug-resistant TB (OR = 3.04, 95\% CI: 1.58-5.85), not have been tested for HIV (OR = 2.30, 95\% CI: 1.50-3.54), drink alcohol at least weekly (OR = 2.22, 95\% CI: 1.40-3.52), be underweight (OR = 2.08, 95\% CI: 1.21-3.56), or not have completed secondary education (OR = 1.55, 95\% CI: 1.03-2.33). Conclusions : Our study identified several factors associated with defaulting from treatment, suggesting a complex set of causes that might lead to default. Addressing these factors individually would be difficult, but they might help to identify certain high-risk patients for supplemental}, articleno = {e0128541}, author = {Lackey, Brian and Seas, Carlos and Van Der Stuyft, Patrick and Otero, Larissa}, issn = {1932-6203}, journal = {PLOS ONE}, keyword = {MULTIDRUG-RESISTANT TUBERCULOSIS,RISK-FACTORS,ADHERENCE,PREDICTORS,STRATEGIES,5-YEAR}, language = {eng}, number = {6}, pages = {11}, title = {Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru}, url = {http://dx.doi.org/10.1371/journal.pone.0128541}, volume = {10}, year = {2015}, }
- Chicago
- Lackey, Brian, Carlos Seas, Patrick Van Der Stuyft, and Larissa Otero. 2015. “Patient Characteristics Associated with Tuberculosis Treatment Default: a Cohort Study in a High-incidence Area of Lima, Peru.” Plos One 10 (6).
- APA
- Lackey, B., Seas, C., Van Der Stuyft, P., & Otero, L. (2015). Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru. PLOS ONE, 10(6).
- Vancouver
- 1.Lackey B, Seas C, Van Der Stuyft P, Otero L. Patient characteristics associated with tuberculosis treatment default: a cohort study in a high-incidence area of Lima, Peru. PLOS ONE. 2015;10(6).
- MLA
- Lackey, Brian, Carlos Seas, Patrick Van Der Stuyft, et al. “Patient Characteristics Associated with Tuberculosis Treatment Default: a Cohort Study in a High-incidence Area of Lima, Peru.” PLOS ONE 10.6 (2015): n. pag. Print.