Advanced search
1 file | 281.97 KB
Author
Organization
Abstract
Objectives: To estimate the proportion of tuberculosis cases attributable to recent transmission and the risk factors possibly associated with tuberculosis clustering. Methods: Population-based study combining information from epidemiological investigation of tuberculosis cases notified to the National Tuberculosis Control Program in Havana, Cuba, in 2009 with the results of genotyping of Mycobacterium tuberculosis isolates with variable number tandem repeat of mycobacterial interspersed repetitive units (MIRU-VNTR) typing. Results: Of 186 cases, 61 were genotyped: 33 patterns and five clusters with 19, 7, 3, 2 and 2 cases were found. The proportion of cases due to recent transmission was 45% (95% confidence interval 33-58%). Routine contact investigation failed to identify a substantial number of epidemiological links. A history of living in a closed setting was strongly associated with clustering. Conclusions: The proportion of cases due to recent transmission in Havana in 2009 is high. The existing control measures in closed settings should be strengthened. A study on a larger number of cases and for a longer time period should be carried out to obtain more precise estimates. Further studies on the utility and cost-effectiveness of the addition of molecular epidemiology techniques to support the progress towards tuberculosis elimination in Cuba, a low-incidence resource-limited setting, are also needed.
Keywords
tuberculosis, molecular epidemiology, MIRU-VNTR typing, Havana, Cuba, FRAGMENT-LENGTH-POLYMORPHISM, MYCOBACTERIUM-TUBERCULOSIS, TRANSMISSION, RESISTANCE, CITY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 281.97 KB

Citation

Please use this url to cite or link to this publication:

Chicago
González Díaz, Alexander, Tullia Battaglioli, Raúl Díaz Rodríguez, Roxana Goza Valdés, Edilberto González Ochoa, and Patrick Van Der Stuyft. 2015. “Molecular Epidemiology of Tuberculosis in Havana, Cuba, 2009.” Tropical Medicine & International Health 20 (11): 1534–1542.
APA
González Díaz, A., Battaglioli, T., Díaz Rodríguez, R., Goza Valdés, R., González Ochoa, E., & Van Der Stuyft, P. (2015). Molecular epidemiology of tuberculosis in Havana, Cuba, 2009. TROPICAL MEDICINE & INTERNATIONAL HEALTH, 20(11), 1534–1542.
Vancouver
1.
González Díaz A, Battaglioli T, Díaz Rodríguez R, Goza Valdés R, González Ochoa E, Van Der Stuyft P. Molecular epidemiology of tuberculosis in Havana, Cuba, 2009. TROPICAL MEDICINE & INTERNATIONAL HEALTH. 2015;20(11):1534–42.
MLA
González Díaz, Alexander et al. “Molecular Epidemiology of Tuberculosis in Havana, Cuba, 2009.” TROPICAL MEDICINE & INTERNATIONAL HEALTH 20.11 (2015): 1534–1542. Print.
@article{6997537,
  abstract     = {Objectives: To estimate the proportion of tuberculosis cases attributable to recent transmission and the risk factors possibly associated with tuberculosis clustering. 
Methods: Population-based study combining information from epidemiological investigation of tuberculosis cases notified to the National Tuberculosis Control Program in Havana, Cuba, in 2009 with the results of genotyping of Mycobacterium tuberculosis isolates with variable number tandem repeat of mycobacterial interspersed repetitive units (MIRU-VNTR) typing. 
Results: Of 186 cases, 61 were genotyped: 33 patterns and five clusters with 19, 7, 3, 2 and 2 cases were found. The proportion of cases due to recent transmission was 45% (95% confidence interval 33-58%). Routine contact investigation failed to identify a substantial number of epidemiological links. A history of living in a closed setting was strongly associated with clustering. 
Conclusions: The proportion of cases due to recent transmission in Havana in 2009 is high. The existing control measures in closed settings should be strengthened. A study on a larger number of cases and for a longer time period should be carried out to obtain more precise estimates. Further studies on the utility and cost-effectiveness of the addition of molecular epidemiology techniques to support the progress towards tuberculosis elimination in Cuba, a low-incidence resource-limited setting, are also needed.},
  author       = {González Díaz, Alexander and Battaglioli, Tullia and Díaz Rodríguez, Raúl and Goza Valdés, Roxana and González Ochoa, Edilberto and Van Der Stuyft, Patrick},
  issn         = {1360-2276},
  journal      = {TROPICAL MEDICINE & INTERNATIONAL HEALTH},
  keywords     = {tuberculosis,molecular epidemiology,MIRU-VNTR typing,Havana,Cuba,FRAGMENT-LENGTH-POLYMORPHISM,MYCOBACTERIUM-TUBERCULOSIS,TRANSMISSION,RESISTANCE,CITY},
  language     = {eng},
  number       = {11},
  pages        = {1534--1542},
  title        = {Molecular epidemiology of tuberculosis in Havana, Cuba, 2009},
  url          = {http://dx.doi.org/10.1111/tmi.12569},
  volume       = {20},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: