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Responsive neurostimulation in epilepsy

Sofie Carrette (UGent) , Paul Boon (UGent) , Mathieu Sprengers (UGent) , Robrecht Raedt (UGent) and Kristl Vonck (UGent)
(2015) EXPERT REVIEW OF NEUROTHERAPEUTICS. 15(12). p.1445-1454
Author
Organization
Project
The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Various neurostimulation modalities have emerged in the field of epilepsy. Despite the fact that delivery of an electrical current to the hyperexcitable epileptic brain might, at first, seem contradictory, neurostimulation has become an established therapeutic option with a promising efficacy and adverse effects profile. In responsive neurostimulation the strategy is to interfere as early as possible with the accumulation of seizure activity to prematurely abort or even prevent an upcoming seizure. The design of technology required for responsive stimulation is more challenging compared with devices for open-loop neurostimulation. The achievement of therapeutic success is dependent on adequate sensing and stimulation algorithms and a fast coupling between both. The benefits of delivering current only at the time of an approaching seizure merit further investigation. Current experience with responsive neurostimulation in epilepsy is still limited, but seems promising.
Keywords
responsive, responsive neurostimulation system (RNS), deep brain stimulation (DBS), closed-loop, drug delivery system, epilepsy, neurostimulation, optogenetics, VAGUS-NERVE-STIMULATION, vagus nerve stimulation (VNS), HEART-RATE-VARIABILITY, REFRACTORY EPILEPSY, ELECTRICAL-STIMULATION, OPTOGENETIC CONTROL, CORTICAL STIMULATION, BRAIN-STIMULATION, PARTIAL SEIZURES, IMPLANTATION, EXCITABILITY

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Citation

Please use this url to cite or link to this publication:

Chicago
Carrette, Sofie, Paul Boon, Mathieu Sprengers, Robrecht Raedt, and Kristl Vonck. 2015. “Responsive Neurostimulation in Epilepsy.” Expert Review of Neurotherapeutics 15 (12): 1445–1454.
APA
Carrette, S., Boon, P., Sprengers, M., Raedt, R., & Vonck, K. (2015). Responsive neurostimulation in epilepsy. EXPERT REVIEW OF NEUROTHERAPEUTICS, 15(12), 1445–1454.
Vancouver
1.
Carrette S, Boon P, Sprengers M, Raedt R, Vonck K. Responsive neurostimulation in epilepsy. EXPERT REVIEW OF NEUROTHERAPEUTICS. 2015;15(12):1445–54.
MLA
Carrette, Sofie, Paul Boon, Mathieu Sprengers, et al. “Responsive Neurostimulation in Epilepsy.” EXPERT REVIEW OF NEUROTHERAPEUTICS 15.12 (2015): 1445–1454. Print.
@article{6988111,
  abstract     = {Various neurostimulation modalities have emerged in the field of epilepsy. Despite the fact that delivery of an electrical current to the hyperexcitable epileptic brain might, at first, seem contradictory, neurostimulation has become an established therapeutic option with a promising efficacy and adverse effects profile. In responsive neurostimulation the strategy is to interfere as early as possible with the accumulation of seizure activity to prematurely abort or even prevent an upcoming seizure. The design of technology required for responsive stimulation is more challenging compared with devices for open-loop neurostimulation. The achievement of therapeutic success is dependent on adequate sensing and stimulation algorithms and a fast coupling between both. The benefits of delivering current only at the time of an approaching seizure merit further investigation. Current experience with responsive neurostimulation in epilepsy is still limited, but seems promising.},
  author       = {Carrette, Sofie and Boon, Paul and Sprengers, Mathieu and Raedt, Robrecht and Vonck, Kristl},
  issn         = {1473-7175},
  journal      = {EXPERT REVIEW OF NEUROTHERAPEUTICS},
  language     = {eng},
  number       = {12},
  pages        = {1445--1454},
  title        = {Responsive neurostimulation in epilepsy},
  url          = {http://dx.doi.org/10.1586/14737175.2015.1113875},
  volume       = {15},
  year         = {2015},
}

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