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Evanescent field biosensor using polymer slab waveguide-based cartridges for the optical detection of nanoparticles

Nuria Teigell Beneitez (UGent) , Jeroen Missinne (UGent) , Emiel WA Visser, Leo J van IJzendoorn, Menno WJ Prins, Jean JHB Schleipen, Jan L Vinkenborg, Gerard Rietjens, Marc A Verschuuren, Ganeshram Krishnamoorthy, et al.
(2016) IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. 22(3).
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Organization
Abstract
We present a polymer optical waveguide integration technology for the detection of nanoparticles in an evanescent field (EF)-based biosensor. Polymer waveguides together with their light coupling structures are designed to be integrated in a novel cartridge concept which will eventually lead to cost-effective, rapid, and easy-to-use point-of-care testing (POCT). The selected slab waveguides generate a homogeneous and well-defined EF, illuminating magnetic nanoparticles that are used as optical contrast labels and are measured using dark-field microscopy. The nanoparticles quantitatively bind to the sensor surface in the presence of target molecules, mediated by antibodies. Compatibility of the waveguide materials with these biomolecules is therefore a strong requirement. When designing a biosensor for POCT, it is also necessary to consider fabrication and manipulation tolerances, targeting the compatibility with mass-production technologies. In this context, polymer optics offer unique advantages, and in combination with the optical contrast labels a very high sensitivity can be achieved. The sensing concept was assessed by comparing various commercially available polymer materials (LightLink, Ormocer, Epocore/Epoclad) in terms of waveguide design and fabrication, optical performance (detection of nanoparticles), and biological compatibility and performance as a sensor surface in an immuno-assay for cardiac troponin I.
Keywords
optical, nanoparticle, point-of-care testing (POCT), point-of-care, polymer, penetration depth, slab waveguide, INTERFEROMETER, dark-field, evanescent field, cardiac troponin I (cTnI), biosensor, biomarker, Antibody

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MLA
Teigell Beneitez, Nuria, et al. “Evanescent Field Biosensor Using Polymer Slab Waveguide-Based Cartridges for the Optical Detection of Nanoparticles.” IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, vol. 22, no. 3, IEEE, 2016, doi:10.1109/JSTQE.2015.2481080.
APA
Teigell Beneitez, N., Missinne, J., Visser, E. W., van IJzendoorn, L. J., Prins, M. W., Schleipen, J. J., … Van Steenberge, G. (2016). Evanescent field biosensor using polymer slab waveguide-based cartridges for the optical detection of nanoparticles. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 22(3). https://doi.org/10.1109/JSTQE.2015.2481080
Chicago author-date
Teigell Beneitez, Nuria, Jeroen Missinne, Emiel WA Visser, Leo J van IJzendoorn, Menno WJ Prins, Jean JHB Schleipen, Jan L Vinkenborg, et al. 2016. “Evanescent Field Biosensor Using Polymer Slab Waveguide-Based Cartridges for the Optical Detection of Nanoparticles.” IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 22 (3). https://doi.org/10.1109/JSTQE.2015.2481080.
Chicago author-date (all authors)
Teigell Beneitez, Nuria, Jeroen Missinne, Emiel WA Visser, Leo J van IJzendoorn, Menno WJ Prins, Jean JHB Schleipen, Jan L Vinkenborg, Gerard Rietjens, Marc A Verschuuren, Ganeshram Krishnamoorthy, Joke G Orsel, and Geert Van Steenberge. 2016. “Evanescent Field Biosensor Using Polymer Slab Waveguide-Based Cartridges for the Optical Detection of Nanoparticles.” IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 22 (3). doi:10.1109/JSTQE.2015.2481080.
Vancouver
1.
Teigell Beneitez N, Missinne J, Visser EW, van IJzendoorn LJ, Prins MW, Schleipen JJ, et al. Evanescent field biosensor using polymer slab waveguide-based cartridges for the optical detection of nanoparticles. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS. 2016;22(3).
IEEE
[1]
N. Teigell Beneitez et al., “Evanescent field biosensor using polymer slab waveguide-based cartridges for the optical detection of nanoparticles,” IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, vol. 22, no. 3, 2016.
@article{6982449,
  abstract     = {{We present a polymer optical waveguide integration technology for the detection of nanoparticles in an evanescent field (EF)-based biosensor. Polymer waveguides together with their light coupling structures are designed to be integrated in a novel cartridge concept which will eventually lead to cost-effective, rapid, and easy-to-use point-of-care testing (POCT). The selected slab waveguides generate a homogeneous and well-defined EF, illuminating magnetic nanoparticles that are used as optical contrast labels and are measured using dark-field microscopy. The nanoparticles quantitatively bind to the sensor surface in the presence of target molecules, mediated by antibodies. Compatibility of the waveguide materials with these biomolecules is therefore a strong requirement. When designing a biosensor for POCT, it is also necessary to consider fabrication and manipulation tolerances, targeting the compatibility with mass-production technologies. In this context, polymer optics offer unique advantages, and in combination with the optical contrast labels a very high sensitivity can be achieved. The sensing concept was assessed by comparing various commercially available polymer materials (LightLink, Ormocer, Epocore/Epoclad) in terms of waveguide design and fabrication, optical performance (detection of nanoparticles), and biological compatibility and performance as a sensor surface in an immuno-assay for cardiac troponin I.}},
  articleno    = {{6900108}},
  author       = {{Teigell Beneitez, Nuria and Missinne, Jeroen and Visser, Emiel WA and van IJzendoorn, Leo J and Prins, Menno WJ and Schleipen, Jean JHB and Vinkenborg, Jan L and Rietjens, Gerard and Verschuuren, Marc A and Krishnamoorthy, Ganeshram and Orsel, Joke G and Van Steenberge, Geert}},
  issn         = {{1077-260X}},
  journal      = {{IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS}},
  keywords     = {{optical,nanoparticle,point-of-care testing (POCT),point-of-care,polymer,penetration depth,slab waveguide,INTERFEROMETER,dark-field,evanescent field,cardiac troponin I (cTnI),biosensor,biomarker,Antibody}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{8}},
  publisher    = {{IEEE}},
  title        = {{Evanescent field biosensor using polymer slab waveguide-based cartridges for the optical detection of nanoparticles}},
  url          = {{http://doi.org/10.1109/JSTQE.2015.2481080}},
  volume       = {{22}},
  year         = {{2016}},
}
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