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Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases

Marjana Brkić (UGent) , Sriram Balusu (UGent) , Claude Libert (UGent) and Roosmarijn Vandenbroucke (UGent)
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Abstract
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shownthat neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases(MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro) inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.
Keywords
AMYOTROPHIC-LATERAL-SCLEROSIS, CENTRAL-NERVOUS-SYSTEM, BLOOD-BRAIN-BARRIER, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, NECROSIS-FACTOR-ALPHA, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, AMYLOID-BETA-PROTEIN, EXPERIMENTAL PNEUMOCOCCAL MENINGITIS, SYNUCLEIN ACTIVATES MICROGLIA, MULTIPLE-SCLEROSIS

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Chicago
Brkić, Marjana, Sriram Balusu, Claude Libert, and Roosmarijn Vandenbroucke. 2015. “Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.” Mediators of Inflammation.
APA
Brkić, M., Balusu, S., Libert, C., & Vandenbroucke, R. (2015). Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases. MEDIATORS OF INFLAMMATION.
Vancouver
1.
Brkić M, Balusu S, Libert C, Vandenbroucke R. Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases. MEDIATORS OF INFLAMMATION. 2015;
MLA
Brkić, Marjana, Sriram Balusu, Claude Libert, et al. “Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases.” MEDIATORS OF INFLAMMATION (2015): n. pag. Print.
@article{6982310,
  abstract     = {Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shownthat neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases(MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro) inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.},
  articleno    = {620581},
  author       = {Brki\'{c}, Marjana and Balusu, Sriram and Libert, Claude and Vandenbroucke, Roosmarijn},
  issn         = {0962-9351},
  journal      = {MEDIATORS OF INFLAMMATION},
  language     = {eng},
  pages        = {27},
  title        = {Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases},
  url          = {http://dx.doi.org/10.1155/2015/620581},
  year         = {2015},
}

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