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A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system

Martin Guilliams (UGent) and Lianne van de Laar (UGent)
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Abstract
The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization. We have recently proposed a novel classification system of mononuclear phagocytes based on their ontogeny. Here, we discuss the practical application of such a classification system through a number of prototypical examples we have encountered while hitchhiking from one subset to another, across species and between steady-state and inflammatory settings. Finally, we discuss the advantages and drawbacks of such a classification system and propose a number of improvements to move from theoretical concepts to concrete guidelines.
Keywords
monocytes, CD8-ALPHA(+) DENDRITIC CELLS, macrophages, dendritic cells, classification, nomenclature, COLONY-STIMULATING FACTOR, TISSUE-RESIDENT MACROPHAGES, BONE-MARROW CULTURES, TRANSCRIPTION FACTOR E2-2, REGULATORY T-CELLS, HUMAN CORD BLOOD, STEADY-STATE, RETINOIC-ACID, IN-VITRO

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Please use this url to cite or link to this publication:

Chicago
Guilliams, Martin, and Lianne van de Laar. 2015. “A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System.” Frontiers in Immunology 6.
APA
Guilliams, M., & van de Laar, L. (2015). A hitchhiker’s guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system. FRONTIERS IN IMMUNOLOGY, 6.
Vancouver
1.
Guilliams M, van de Laar L. A hitchhiker’s guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system. FRONTIERS IN IMMUNOLOGY. 2015;6.
MLA
Guilliams, Martin, and Lianne van de Laar. “A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System.” FRONTIERS IN IMMUNOLOGY 6 (2015): n. pag. Print.
@article{6975404,
  abstract     = {The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization. We have recently proposed a novel classification system of mononuclear phagocytes based on their ontogeny. Here, we discuss the practical application of such a classification system through a number of prototypical examples we have encountered while hitchhiking from one subset to another, across species and between steady-state and inflammatory settings. Finally, we discuss the advantages and drawbacks of such a classification system and propose a number of improvements to move from theoretical concepts to concrete guidelines.},
  articleno    = {406},
  author       = {Guilliams, Martin and van de Laar, Lianne},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {monocytes,CD8-ALPHA(+) DENDRITIC CELLS,macrophages,dendritic cells,classification,nomenclature,COLONY-STIMULATING FACTOR,TISSUE-RESIDENT MACROPHAGES,BONE-MARROW CULTURES,TRANSCRIPTION FACTOR E2-2,REGULATORY T-CELLS,HUMAN CORD BLOOD,STEADY-STATE,RETINOIC-ACID,IN-VITRO},
  language     = {eng},
  pages        = {12},
  title        = {A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system},
  url          = {http://dx.doi.org/10.3389/fimmu.2015.00406},
  volume       = {6},
  year         = {2015},
}

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