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Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators

Nane Vanparijs (UGent) , Ruben De Coen (UGent) , Duchan Laplace (UGent) , Benoit Louage (UGent) , Samarendra Maji (UGent) , Lien Lybaert (UGent) , Richard Hoogenboom (UGent) and Bruno De Geest (UGent)
(2015) CHEMICAL COMMUNICATIONS. 51(73). p.13972-13975
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Abstract
We report on transiently responsive protein-polymer conjugates that temporarily change their protein conformation from the soluble to the particle-like state. 'Grafting-from' RAFT polymerization of a dioxolane-containing acrylamide with a protein macroCTA is used to design polymer-protein conjugates that self-assemble into nano-particles at physiological temperature and pH. Acid triggered hydrolysis of the dioxolane units into diolmoeities rendered the conjugates fully water soluble irrespective of temperature.
Keywords
DENDRITIC CELLS, RADICAL POLYMERIZATION, DRUG-DELIVERY, NANOPARTICLES, VACCINES, ACTIVATION

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MLA
Vanparijs, Nane, et al. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS, vol. 51, no. 73, 2015, pp. 13972–75, doi:10.1039/C5CC04809E.
APA
Vanparijs, N., De Coen, R., Laplace, D., Louage, B., Maji, S., Lybaert, L., … De Geest, B. (2015). Transiently responsive protein–polymer conjugates via a “grafting-from” RAFT approach for intracellular co-delivery of proteins and immune-modulators. CHEMICAL COMMUNICATIONS, 51(73), 13972–13975. https://doi.org/10.1039/C5CC04809E
Chicago author-date
Vanparijs, Nane, Ruben De Coen, Duchan Laplace, Benoit Louage, Samarendra Maji, Lien Lybaert, Richard Hoogenboom, and Bruno De Geest. 2015. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS 51 (73): 13972–75. https://doi.org/10.1039/C5CC04809E.
Chicago author-date (all authors)
Vanparijs, Nane, Ruben De Coen, Duchan Laplace, Benoit Louage, Samarendra Maji, Lien Lybaert, Richard Hoogenboom, and Bruno De Geest. 2015. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS 51 (73): 13972–13975. doi:10.1039/C5CC04809E.
Vancouver
1.
Vanparijs N, De Coen R, Laplace D, Louage B, Maji S, Lybaert L, et al. Transiently responsive protein–polymer conjugates via a “grafting-from” RAFT approach for intracellular co-delivery of proteins and immune-modulators. CHEMICAL COMMUNICATIONS. 2015;51(73):13972–5.
IEEE
[1]
N. Vanparijs et al., “Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators,” CHEMICAL COMMUNICATIONS, vol. 51, no. 73, pp. 13972–13975, 2015.
@article{6973354,
  abstract     = {{We report on transiently responsive protein-polymer conjugates that temporarily change their protein conformation from the soluble to the particle-like state. 'Grafting-from' RAFT polymerization of a dioxolane-containing acrylamide with a protein macroCTA is used to design polymer-protein conjugates that self-assemble into nano-particles at physiological temperature and pH. Acid triggered hydrolysis of the dioxolane units into diolmoeities rendered the conjugates fully water soluble irrespective of temperature.}},
  author       = {{Vanparijs, Nane and De Coen, Ruben and Laplace, Duchan and Louage, Benoit and Maji, Samarendra and Lybaert, Lien and Hoogenboom, Richard and De Geest, Bruno}},
  issn         = {{1359-7345}},
  journal      = {{CHEMICAL COMMUNICATIONS}},
  keywords     = {{DENDRITIC CELLS,RADICAL POLYMERIZATION,DRUG-DELIVERY,NANOPARTICLES,VACCINES,ACTIVATION}},
  language     = {{eng}},
  number       = {{73}},
  pages        = {{13972--13975}},
  title        = {{Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators}},
  url          = {{http://doi.org/10.1039/C5CC04809E}},
  volume       = {{51}},
  year         = {{2015}},
}

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