Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators
- Author
- Nane Vanparijs (UGent) , Ruben De Coen (UGent) , Duchan Laplace (UGent) , Benoit Louage (UGent) , Samarendra Maji (UGent) , Lien Lybaert (UGent) , Richard Hoogenboom (UGent) and Bruno De Geest (UGent)
- Organization
- Abstract
- We report on transiently responsive protein-polymer conjugates that temporarily change their protein conformation from the soluble to the particle-like state. 'Grafting-from' RAFT polymerization of a dioxolane-containing acrylamide with a protein macroCTA is used to design polymer-protein conjugates that self-assemble into nano-particles at physiological temperature and pH. Acid triggered hydrolysis of the dioxolane units into diolmoeities rendered the conjugates fully water soluble irrespective of temperature.
- Keywords
- DENDRITIC CELLS, RADICAL POLYMERIZATION, DRUG-DELIVERY, NANOPARTICLES, VACCINES, ACTIVATION
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-6973354
- MLA
- Vanparijs, Nane, et al. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS, vol. 51, no. 73, 2015, pp. 13972–75, doi:10.1039/C5CC04809E.
- APA
- Vanparijs, N., De Coen, R., Laplace, D., Louage, B., Maji, S., Lybaert, L., … De Geest, B. (2015). Transiently responsive protein–polymer conjugates via a “grafting-from” RAFT approach for intracellular co-delivery of proteins and immune-modulators. CHEMICAL COMMUNICATIONS, 51(73), 13972–13975. https://doi.org/10.1039/C5CC04809E
- Chicago author-date
- Vanparijs, Nane, Ruben De Coen, Duchan Laplace, Benoit Louage, Samarendra Maji, Lien Lybaert, Richard Hoogenboom, and Bruno De Geest. 2015. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS 51 (73): 13972–75. https://doi.org/10.1039/C5CC04809E.
- Chicago author-date (all authors)
- Vanparijs, Nane, Ruben De Coen, Duchan Laplace, Benoit Louage, Samarendra Maji, Lien Lybaert, Richard Hoogenboom, and Bruno De Geest. 2015. “Transiently Responsive Protein–Polymer Conjugates via a ‘grafting-from’ RAFT Approach for Intracellular Co-Delivery of Proteins and Immune-Modulators.” CHEMICAL COMMUNICATIONS 51 (73): 13972–13975. doi:10.1039/C5CC04809E.
- Vancouver
- 1.Vanparijs N, De Coen R, Laplace D, Louage B, Maji S, Lybaert L, et al. Transiently responsive protein–polymer conjugates via a “grafting-from” RAFT approach for intracellular co-delivery of proteins and immune-modulators. CHEMICAL COMMUNICATIONS. 2015;51(73):13972–5.
- IEEE
- [1]N. Vanparijs et al., “Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators,” CHEMICAL COMMUNICATIONS, vol. 51, no. 73, pp. 13972–13975, 2015.
@article{6973354, abstract = {{We report on transiently responsive protein-polymer conjugates that temporarily change their protein conformation from the soluble to the particle-like state. 'Grafting-from' RAFT polymerization of a dioxolane-containing acrylamide with a protein macroCTA is used to design polymer-protein conjugates that self-assemble into nano-particles at physiological temperature and pH. Acid triggered hydrolysis of the dioxolane units into diolmoeities rendered the conjugates fully water soluble irrespective of temperature.}}, author = {{Vanparijs, Nane and De Coen, Ruben and Laplace, Duchan and Louage, Benoit and Maji, Samarendra and Lybaert, Lien and Hoogenboom, Richard and De Geest, Bruno}}, issn = {{1359-7345}}, journal = {{CHEMICAL COMMUNICATIONS}}, keywords = {{DENDRITIC CELLS,RADICAL POLYMERIZATION,DRUG-DELIVERY,NANOPARTICLES,VACCINES,ACTIVATION}}, language = {{eng}}, number = {{73}}, pages = {{13972--13975}}, title = {{Transiently responsive protein–polymer conjugates via a 'grafting-from' RAFT approach for intracellular co-delivery of proteins and immune-modulators}}, url = {{http://doi.org/10.1039/C5CC04809E}}, volume = {{51}}, year = {{2015}}, }
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