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Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders

(2015) DRUG DISCOVERY TODAY. 20(8). p.928-941
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Abstract
The choroid plexus (CP) is a highly vascularized organ located in the brain ventricles and contains a single epithelial cell layer forming the blood-cerebrospinal fluid barrier (BCSFB). This barrier is crucial for immune surveillance in health and is an underestimated gate for entry of immune cells during numerous inflammatory disorders. Several of these disorders are accompanied by disturbance of the BCSFB and increased leukocyte infiltration, which affects neuroinflammation. Understanding the mechanism of immune cell entry at the CP might lead to identification of new therapeutic targets. Here, we focus on current knowledge of leukocyte infiltration at the CP in inflammatory conditions and its therapeutic implications.
Keywords
TRAUMATIC BRAIN-INJURY, CEREBROSPINAL FLUID BARRIER, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, CENTRAL-NERVOUS-SYSTEM, SPINAL-CORD-INJURY, MONOCYTE CHEMOATTRACTANT PROTEIN-1, FELINE IMMUNODEFICIENCY VIRUS, BLOOD-CSF BARRIER, WEST NILE VIRUS, PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY

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Citation

Please use this url to cite or link to this publication:

Chicago
Demeestere, Delphine, Claude Libert, and Roosmarijn Vandenbroucke. 2015. “Clinical Implications of Leukocyte Infiltration at the Choroid Plexus in (neuro)inflammatory Disorders.” Drug Discovery Today 20 (8): 928–941.
APA
Demeestere, D., Libert, C., & Vandenbroucke, R. (2015). Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders. DRUG DISCOVERY TODAY, 20(8), 928–941.
Vancouver
1.
Demeestere D, Libert C, Vandenbroucke R. Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders. DRUG DISCOVERY TODAY. 2015;20(8):928–41.
MLA
Demeestere, Delphine, Claude Libert, and Roosmarijn Vandenbroucke. “Clinical Implications of Leukocyte Infiltration at the Choroid Plexus in (neuro)inflammatory Disorders.” DRUG DISCOVERY TODAY 20.8 (2015): 928–941. Print.
@article{6973333,
  abstract     = {The choroid plexus (CP) is a highly vascularized organ located in the brain ventricles and contains a single epithelial cell layer forming the blood-cerebrospinal fluid barrier (BCSFB). This barrier is crucial for immune surveillance in health and is an underestimated gate for entry of immune cells during numerous inflammatory disorders. Several of these disorders are accompanied by disturbance of the BCSFB and increased leukocyte infiltration, which affects neuroinflammation. Understanding the mechanism of immune cell entry at the CP might lead to identification of new therapeutic targets. Here, we focus on current knowledge of leukocyte infiltration at the CP in inflammatory conditions and its therapeutic implications.},
  author       = {Demeestere, Delphine and Libert, Claude and Vandenbroucke, Roosmarijn},
  issn         = {1359-6446},
  journal      = {DRUG DISCOVERY TODAY},
  language     = {eng},
  number       = {8},
  pages        = {928--941},
  title        = {Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders},
  url          = {http://dx.doi.org/10.1016/j.drudis.2015.05.003},
  volume       = {20},
  year         = {2015},
}

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