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MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

Inna Afonina (UGent) , Lynn Elton (UGent) , Isabelle Carpentier (UGent) and Rudi Beyaert (UGent)
(2015) FEBS JOURNAL. 282(17). p.3286-3297
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Abstract
The paracaspase MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1) is an intracellular signaling protein that plays a key role in innate and adaptive immunity. It is essential for nuclear factor kappa B (NF-kappa B) activation and proinflammatory gene expression downstream of several cell surface receptors. MALT1 has been most studied in the context of T-cell receptor-induced NF-kappa B signaling, supporting T-cell activation and proliferation. In addition, MALT1 hyperactivation is associated with specific subtypes of B-cell lymphoma, where it controls tumor cell proliferation and survival. For a long time, MALT1 was believed to function solely as a scaffold protein, providing a platform for the assembly of other NF-kappa B signaling proteins. However, this view changed dramatically when MALT1 was found to have proteolytic activity that further fine-tunes signaling. MALT1 proteolytic activity is essential for T-cell activation and lymphomagenesis, suggesting that MALT1 is a promising therapeutic target for the treatment of autoimmune diseases and distinct lymphoma entities. However, interference with MALT1 activity may pose a dangerous threat to the normal functioning of the immune system and should be evaluated with great care. Here we discuss the current knowledge on the scaffold and protease functions of MALT1, including an overview of its substrates and the functional implications of their cleavage.
Keywords
inflammation, immunity, MALT1, nuclear factor-kappa B, paracaspase, protease substrates, proteases, T-cell receptor, T-CELL-ACTIVATION, PARACASPASE MALT1, LYMPHOCYTE-ACTIVATION, SIGNALING PATHWAY, PROTEASE ACTIVITY, ANTIGEN RECEPTOR, PHARMACOLOGICAL INHIBITION, COMBINED IMMUNODEFICIENCY, IMMUNE-RESPONSES, TUMOR-SUPPRESSOR, cancer, B-cell lymphoma

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Citation

Please use this url to cite or link to this publication:

MLA
Afonina, Inna et al. “MALT1-a Universal Soldier: Multiple Strategies to Ensure NF-κB Activation and Target Gene Expression.” FEBS JOURNAL 282.17 (2015): 3286–3297. Print.
APA
Afonina, I., Elton, L., Carpentier, I., & Beyaert, R. (2015). MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression. FEBS JOURNAL, 282(17), 3286–3297.
Chicago author-date
Afonina, Inna, Lynn Elton, Isabelle Carpentier, and Rudi Beyaert. 2015. “MALT1-a Universal Soldier: Multiple Strategies to Ensure NF-κB Activation and Target Gene Expression.” Febs Journal 282 (17): 3286–3297.
Chicago author-date (all authors)
Afonina, Inna, Lynn Elton, Isabelle Carpentier, and Rudi Beyaert. 2015. “MALT1-a Universal Soldier: Multiple Strategies to Ensure NF-κB Activation and Target Gene Expression.” Febs Journal 282 (17): 3286–3297.
Vancouver
1.
Afonina I, Elton L, Carpentier I, Beyaert R. MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression. FEBS JOURNAL. 2015;282(17):3286–97.
IEEE
[1]
I. Afonina, L. Elton, I. Carpentier, and R. Beyaert, “MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression,” FEBS JOURNAL, vol. 282, no. 17, pp. 3286–3297, 2015.
@article{6973179,
  abstract     = {The paracaspase MALT1 (mucosa associated lymphoid tissue lymphoma translocation gene 1) is an intracellular signaling protein that plays a key role in innate and adaptive immunity. It is essential for nuclear factor kappa B (NF-kappa B) activation and proinflammatory gene expression downstream of several cell surface receptors. MALT1 has been most studied in the context of T-cell receptor-induced NF-kappa B signaling, supporting T-cell activation and proliferation. In addition, MALT1 hyperactivation is associated with specific subtypes of B-cell lymphoma, where it controls tumor cell proliferation and survival. For a long time, MALT1 was believed to function solely as a scaffold protein, providing a platform for the assembly of other NF-kappa B signaling proteins. However, this view changed dramatically when MALT1 was found to have proteolytic activity that further fine-tunes signaling. MALT1 proteolytic activity is essential for T-cell activation and lymphomagenesis, suggesting that MALT1 is a promising therapeutic target for the treatment of autoimmune diseases and distinct lymphoma entities. However, interference with MALT1 activity may pose a dangerous threat to the normal functioning of the immune system and should be evaluated with great care. Here we discuss the current knowledge on the scaffold and protease functions of MALT1, including an overview of its substrates and the functional implications of their cleavage.},
  author       = {Afonina, Inna and Elton, Lynn and Carpentier, Isabelle and Beyaert, Rudi},
  issn         = {1742-464X},
  journal      = {FEBS JOURNAL},
  keywords     = {inflammation,immunity,MALT1,nuclear factor-kappa B,paracaspase,protease substrates,proteases,T-cell receptor,T-CELL-ACTIVATION,PARACASPASE MALT1,LYMPHOCYTE-ACTIVATION,SIGNALING PATHWAY,PROTEASE ACTIVITY,ANTIGEN RECEPTOR,PHARMACOLOGICAL INHIBITION,COMBINED IMMUNODEFICIENCY,IMMUNE-RESPONSES,TUMOR-SUPPRESSOR,cancer,B-cell lymphoma},
  language     = {eng},
  number       = {17},
  pages        = {3286--3297},
  title        = {MALT1-a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression},
  url          = {http://dx.doi.org/10.1111/febs.13325},
  volume       = {282},
  year         = {2015},
}

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