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Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? : the MeDALL hypothesis

(2015) ALLERGY. 70(9). p.1062-1078
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are associated with allergen-specific IgE and nonallergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono- and polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE-mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal type 2 signalling. Asthma, rhinitis and AD are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This study proposes a new classification of IgE-mediated allergic diseases that allows the definition of novel phenotypes to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis and (iii) propose novel strategies of treatment and prevention.
Keywords
rhinitis, SKIN PRICK TEST, GENOME-WIDE ASSOCIATION, ORAL FOOD CHALLENGES, SOYBEAN EPIDEMIC ASTHMA, SERUM IMMUNOGLOBULIN-E, ACTIVE EOSINOPHILIC ESOPHAGITIS, EPITHELIAL BARRIER FUNCTION, GENERAL-POPULATION SAMPLE, asthma, atopic dermatitis, IgE, polysensitization, SEVERE ATOPIC-DERMATITIS, HEALTH-SURVEY-I

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Citation

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Chicago
Bousquet, J, JM Anto, M Wickman, T Keil, R Valenta, T Haahtela, K Lodrup Carlsen, et al. 2015. “Are Allergic Multimorbidities and IgE Polysensitization Associated with the Persistence or Re-occurrence of Foetal Type 2 Signalling? : the MeDALL Hypothesis.” Allergy 70 (9): 1062–1078.
APA
Bousquet, J, Anto, J., Wickman, M., Keil, T., Valenta, R., Haahtela, T., Lodrup Carlsen, K., et al. (2015). Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? : the MeDALL hypothesis. ALLERGY, 70(9), 1062–1078.
Vancouver
1.
Bousquet J, Anto J, Wickman M, Keil T, Valenta R, Haahtela T, et al. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? : the MeDALL hypothesis. ALLERGY. 2015;70(9):1062–78.
MLA
Bousquet, J, JM Anto, M Wickman, et al. “Are Allergic Multimorbidities and IgE Polysensitization Associated with the Persistence or Re-occurrence of Foetal Type 2 Signalling? : the MeDALL Hypothesis.” ALLERGY 70.9 (2015): 1062–1078. Print.
@article{6973103,
  abstract     = {Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are associated with allergen-specific IgE and nonallergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono- and polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE-mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal type 2 signalling. Asthma, rhinitis and AD are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This study proposes a new classification of IgE-mediated allergic diseases that allows the definition of novel phenotypes to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis and (iii) propose novel strategies of treatment and prevention.},
  author       = {Bousquet, J and Anto, JM and Wickman, M and Keil, T and Valenta, R and Haahtela, T and Lodrup Carlsen, K and van Hage, M and Akdis, C and Bachert, Claus and Akdis, M and Auffray, C and Annesi-Maesano, I and Bindslev-Jensen, C and Cambon-Thomsen, A and Carlsen, KH and Chatzi, L and Forastiere, F and Garcia-Aymerich, J and Gehrig, U and Guerra, S and Heinrich, J and Koppelman, GH and Kowalski, ML and Lambrecht, Bart and Lupinek, C and Maier, D and Mel{\'e}n, E and Momas, I and Palkonen, S and Pinart, M and Postma, D and Siroux, V and Smit, HA and Sunyer, J and Wright, J and Zuberbier, T and Arshad, SH and Nadif, R and Thijs, C and Andersson, N and Asarnoj, A and Ballardini, N and Ballereau, S and Bedbrook, A and Benet, M and Bergstrom, A and Brunekreef, B and Burte, E and Calderon, M and De Carlo, G and Demoly, P and Eller, E and Fantini, MP and Hammad, Hamida and Hohman, C and Just, J and Kerkhof, M and Kogevinas, M and Kull, I and Lau, S and Lemonnier, N and Mommers, M and Nawijn, M and Neubauer, A and Oddie, S and Pellet, J and Pin, I and Porta, D and Saeys, Yvan and Skrindo, I and Tischer, CG and Torrent, M and von Hertzen, L},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {rhinitis,SKIN PRICK TEST,GENOME-WIDE ASSOCIATION,ORAL FOOD CHALLENGES,SOYBEAN EPIDEMIC ASTHMA,SERUM IMMUNOGLOBULIN-E,ACTIVE EOSINOPHILIC ESOPHAGITIS,EPITHELIAL BARRIER FUNCTION,GENERAL-POPULATION SAMPLE,asthma,atopic dermatitis,IgE,polysensitization,SEVERE ATOPIC-DERMATITIS,HEALTH-SURVEY-I},
  language     = {eng},
  number       = {9},
  pages        = {1062--1078},
  title        = {Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? : the MeDALL hypothesis},
  url          = {http://dx.doi.org/10.1111/all.12637},
  volume       = {70},
  year         = {2015},
}

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