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Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites

Jonathan Coquet, Martijn Schuijs UGent, Mark J Smyth, Kim Deswarte UGent, Rudi Beyaert UGent, Harald Braun UGent, Louis Boon, Gunilla B Karlsson Hedestam, Steven L Nutt, Hamida Hammad UGent, et al. (2015) IMMUNITY. 43(2). p.318-330
abstract
Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ALLERGIC LUNG INFLAMMATION, FOLLICULAR-HELPER-CELLS, INNATE LYMPHOID-CELLS, TH2 EFFECTOR FUNCTION, B-CELLS, IN-VIVO, CYTOKINE PRODUCTION, HELMINTH INFECTION, DENDRITIC CELLS, RECEPTOR
journal title
IMMUNITY
Immunity
volume
43
issue
2
pages
318 - 330
Web of Science type
Article
Web of Science id
000360101200014
JCR category
IMMUNOLOGY
JCR impact factor
24.082 (2015)
JCR rank
3/150 (2015)
JCR quartile
1 (2015)
ISSN
1074-7613
DOI
10.1016/j.immuni.2015.07.015
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors are co-first authors
copyright statement
I have transferred the copyright for this publication to the publisher
id
6971911
handle
http://hdl.handle.net/1854/LU-6971911
date created
2015-10-30 17:03:24
date last changed
2016-12-19 15:45:17
@article{6971911,
  abstract     = {Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.},
  author       = {Coquet, Jonathan and Schuijs, Martijn and Smyth, Mark J and Deswarte, Kim and Beyaert, Rudi and Braun, Harald and Boon, Louis and Hedestam, Gunilla B Karlsson and Nutt, Steven L and Hammad, Hamida and Lambrecht, Bart},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keyword      = {ALLERGIC LUNG INFLAMMATION,FOLLICULAR-HELPER-CELLS,INNATE LYMPHOID-CELLS,TH2 EFFECTOR FUNCTION,B-CELLS,IN-VIVO,CYTOKINE PRODUCTION,HELMINTH INFECTION,DENDRITIC CELLS,RECEPTOR},
  language     = {eng},
  number       = {2},
  pages        = {318--330},
  title        = {Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites},
  url          = {http://dx.doi.org/10.1016/j.immuni.2015.07.015},
  volume       = {43},
  year         = {2015},
}

Chicago
Coquet, Jonathan, Martijn Schuijs, Mark J Smyth, Kim Deswarte, Rudi Beyaert, Harald Braun, Louis Boon, et al. 2015. “Interleukin-21-producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.” Immunity 43 (2): 318–330.
APA
Coquet, J., Schuijs, M., Smyth, M. J., Deswarte, K., Beyaert, R., Braun, H., Boon, L., et al. (2015). Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites. IMMUNITY, 43(2), 318–330.
Vancouver
1.
Coquet J, Schuijs M, Smyth MJ, Deswarte K, Beyaert R, Braun H, et al. Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites. IMMUNITY. 2015;43(2):318–30.
MLA
Coquet, Jonathan, Martijn Schuijs, Mark J Smyth, et al. “Interleukin-21-producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites.” IMMUNITY 43.2 (2015): 318–330. Print.