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Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

Barbora Vesela, Eva Svandova, Tom Vanden Berghe (UGent) , Abigail S Tucker, Peter Vandenabeele (UGent) and Eva Matalova
(2015) JOURNAL OF MOLECULAR HISTOLOGY. 46(4-5). p.443-455
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Abstract
Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
Keywords
Non-apoptotic, MAST-CELLS, Mast cells, Hair follicles, Development, Caspase-7, GENES, KERATINOCYTES, SKIN, EXPRESSION, ACTIVATION, LOCALIZATION, PROLIFERATION, REGRESSION CATAGEN, TERMINAL DIFFERENTIATION

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Citation

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MLA
Vesela, Barbora, et al. “Non-Apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” JOURNAL OF MOLECULAR HISTOLOGY, vol. 46, no. 4–5, 2015, pp. 443–55, doi:10.1007/s10735-015-9636-1.
APA
Vesela, B., Svandova, E., Vanden Berghe, T., Tucker, A. S., Vandenabeele, P., & Matalova, E. (2015). Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. JOURNAL OF MOLECULAR HISTOLOGY, 46(4–5), 443–455. https://doi.org/10.1007/s10735-015-9636-1
Chicago author-date
Vesela, Barbora, Eva Svandova, Tom Vanden Berghe, Abigail S Tucker, Peter Vandenabeele, and Eva Matalova. 2015. “Non-Apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” JOURNAL OF MOLECULAR HISTOLOGY 46 (4–5): 443–55. https://doi.org/10.1007/s10735-015-9636-1.
Chicago author-date (all authors)
Vesela, Barbora, Eva Svandova, Tom Vanden Berghe, Abigail S Tucker, Peter Vandenabeele, and Eva Matalova. 2015. “Non-Apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” JOURNAL OF MOLECULAR HISTOLOGY 46 (4–5): 443–455. doi:10.1007/s10735-015-9636-1.
Vancouver
1.
Vesela B, Svandova E, Vanden Berghe T, Tucker AS, Vandenabeele P, Matalova E. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. JOURNAL OF MOLECULAR HISTOLOGY. 2015;46(4–5):443–55.
IEEE
[1]
B. Vesela, E. Svandova, T. Vanden Berghe, A. S. Tucker, P. Vandenabeele, and E. Matalova, “Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue,” JOURNAL OF MOLECULAR HISTOLOGY, vol. 46, no. 4–5, pp. 443–455, 2015.
@article{6971767,
  abstract     = {{Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.}},
  author       = {{Vesela, Barbora and Svandova, Eva and Vanden Berghe, Tom and Tucker, Abigail S and Vandenabeele, Peter and Matalova, Eva}},
  issn         = {{1567-2379}},
  journal      = {{JOURNAL OF MOLECULAR HISTOLOGY}},
  keywords     = {{Non-apoptotic,MAST-CELLS,Mast cells,Hair follicles,Development,Caspase-7,GENES,KERATINOCYTES,SKIN,EXPRESSION,ACTIVATION,LOCALIZATION,PROLIFERATION,REGRESSION CATAGEN,TERMINAL DIFFERENTIATION}},
  language     = {{eng}},
  number       = {{4-5}},
  pages        = {{443--455}},
  title        = {{Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue}},
  url          = {{http://dx.doi.org/10.1007/s10735-015-9636-1}},
  volume       = {{46}},
  year         = {{2015}},
}
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