Advanced search
1 file | 4.03 MB Add to list

Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue

(2015) JOURNAL OF MOLECULAR HISTOLOGY. 46(4-5). p.443-455
Author
Organization
Abstract
Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.
Keywords
Non-apoptotic, MAST-CELLS, Mast cells, Hair follicles, Development, Caspase-7, GENES, KERATINOCYTES, SKIN, EXPRESSION, ACTIVATION, LOCALIZATION, PROLIFERATION, REGRESSION CATAGEN, TERMINAL DIFFERENTIATION

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 4.03 MB

Citation

Please use this url to cite or link to this publication:

MLA
Vesela, Barbora et al. “Non-apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” JOURNAL OF MOLECULAR HISTOLOGY 46.4-5 (2015): 443–455. Print.
APA
Vesela, B., Svandova, E., Vanden Berghe, T., Tucker, A. S., Vandenabeele, P., & Matalova, E. (2015). Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. JOURNAL OF MOLECULAR HISTOLOGY, 46(4-5), 443–455.
Chicago author-date
Vesela, Barbora, Eva Svandova, Tom Vanden Berghe, Abigail S Tucker, Peter Vandenabeele, and Eva Matalova. 2015. “Non-apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” Journal of Molecular Histology 46 (4-5): 443–455.
Chicago author-date (all authors)
Vesela, Barbora, Eva Svandova, Tom Vanden Berghe, Abigail S Tucker, Peter Vandenabeele, and Eva Matalova. 2015. “Non-apoptotic Role for Caspase-7 in Hair Follicles and the Surrounding Tissue.” Journal of Molecular Histology 46 (4-5): 443–455.
Vancouver
1.
Vesela B, Svandova E, Vanden Berghe T, Tucker AS, Vandenabeele P, Matalova E. Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue. JOURNAL OF MOLECULAR HISTOLOGY. 2015;46(4-5):443–55.
IEEE
[1]
B. Vesela, E. Svandova, T. Vanden Berghe, A. S. Tucker, P. Vandenabeele, and E. Matalova, “Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue,” JOURNAL OF MOLECULAR HISTOLOGY, vol. 46, no. 4–5, pp. 443–455, 2015.
@article{6971767,
  abstract     = {Hair follicles are unique organs undergoing regular cycles of proliferation, differentiation, and apoptosis. The final step of apoptosis is, in general, mediated by executioner caspases comprising caspase-3, -6 and -7. Despite their commonly accepted apoptotic function, executioner caspases also participate in non-apoptotic processes. In the present study, we investigated activation (cleavage) of caspase-7 in mouse hair follicles and surrounding tissue during embryonic development into adulthood. Casp7 (-/-) mice were examined to understand the effect of caspase-7 deficiency in the skin. The activated form of caspase-7 was observed during embryonic hair follicle development, as well as in the first hair cycle. In general, activation of caspase-7 did not correlate with apoptosis and activation of caspase-3, except during physiological hair follicle regression. Notably, cleaved caspase-7 was observed in mast cells and its deficiency in the adult skin resulted in increased mast cell number. Our study shows for the first time activated caspase-7 in hair follicles and mast cells and indicates its non-apoptotic roles in the skin.},
  author       = {Vesela, Barbora and Svandova, Eva and Vanden Berghe, Tom and Tucker, Abigail S and Vandenabeele, Peter and Matalova, Eva},
  issn         = {1567-2379},
  journal      = {JOURNAL OF MOLECULAR HISTOLOGY},
  keywords     = {Non-apoptotic,MAST-CELLS,Mast cells,Hair follicles,Development,Caspase-7,GENES,KERATINOCYTES,SKIN,EXPRESSION,ACTIVATION,LOCALIZATION,PROLIFERATION,REGRESSION CATAGEN,TERMINAL DIFFERENTIATION},
  language     = {eng},
  number       = {4-5},
  pages        = {443--455},
  title        = {Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue},
  url          = {http://dx.doi.org/10.1007/s10735-015-9636-1},
  volume       = {46},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: