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Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster

J Garcia-Aymerich, M Benet, Yvan Saeys UGent, M Pinart, X Basagaña, HA Smit, V Siroux, J Just, I Momas, F Rancière, et al. (2015) ALLERGY. 70(8). p.973-984
abstract
Background: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques. Methods: We included 17209 children at 4years and 14585 at 8years from seven European population-based birth cohorts (MeDALL project). At each age period, children were grouped, using partitioning cluster analysis, according to the distribution of 23 variables covering symptoms ever' and in the last 12months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and eczema; immunoglobulin E sensitization; weight; and height. We tested the sensitivity of our estimates to subject and variable selections, and to different statistical approaches, including latent class analysis and self-organizing maps. Results: Two groups were identified as the optimal way to cluster the data at both age periods and in all sensitivity analyses. The first (reference) group at 4 and 8years (including 70% and 79% of children, respectively) was characterized by a low prevalence of symptoms and sensitization, whereas the second (symptomatic) group exhibited more frequent symptoms and sensitization. Ninety-nine percentage of children with comorbidities (co-occurrence of asthma, rhinitis and/or eczema) were included in the symptomatic group at both ages. The children's characteristics in both groups were consistent in all sensitivity analyses. Conclusion: At 4 and 8years, at the population level, asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster. Future research including time-repeated assessments and biological data will help understanding the interrelationships between these diseases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
eczema, rhinitis, LATENT CLASS ANALYSIS, ATOPIC-DERMATITIS, CHILDHOOD ASTHMA, ASSOCIATIONS, PREVENTION, COUGH, SENSITIZATION, ORGANIZATION, MECHANISMS, SYMPTOMS, cluster analysis, asthma, allergy
journal title
ALLERGY
Allergy
volume
70
issue
8
pages
973 - 984
Web of Science type
Article
Web of Science id
000358608500009
JCR category
ALLERGY
JCR impact factor
6.335 (2015)
JCR rank
2/25 (2015)
JCR quartile
1 (2015)
ISSN
0105-4538
DOI
10.1111/all.12640
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6971542
handle
http://hdl.handle.net/1854/LU-6971542
date created
2015-10-30 15:14:04
date last changed
2016-12-19 15:42:05
@article{6971542,
  abstract     = {Background: Asthma, rhinitis and eczema often co-occur in children, but their interrelationships at the population level have been poorly addressed. We assessed co-occurrence of childhood asthma, rhinitis and eczema using unsupervised statistical techniques.
Methods: We included 17209 children at 4years and 14585 at 8years from seven European population-based birth cohorts (MeDALL project). At each age period, children were grouped, using partitioning cluster analysis, according to the distribution of 23 variables covering symptoms ever' and in the last 12months', doctor diagnosis, age of onset and treatments of asthma, rhinitis and eczema; immunoglobulin E sensitization; weight; and height. We tested the sensitivity of our estimates to subject and variable selections, and to different statistical approaches, including latent class analysis and self-organizing maps.
Results: Two groups were identified as the optimal way to cluster the data at both age periods and in all sensitivity analyses. The first (reference) group at 4 and 8years (including 70\% and 79\% of children, respectively) was characterized by a low prevalence of symptoms and sensitization, whereas the second (symptomatic) group exhibited more frequent symptoms and sensitization. Ninety-nine percentage of children with comorbidities (co-occurrence of asthma, rhinitis and/or eczema) were included in the symptomatic group at both ages. The children's characteristics in both groups were consistent in all sensitivity analyses.
Conclusion: At 4 and 8years, at the population level, asthma, rhinitis and eczema can be classified together as an allergic comorbidity cluster. Future research including time-repeated assessments and biological data will help understanding the interrelationships between these diseases.},
  author       = {Garcia-Aymerich, J and Benet, M and Saeys, Yvan and Pinart, M and Basaga{\~n}a, X and Smit, HA and Siroux, V and Just, J and Momas, I and Ranci{\`e}re, F and Keil, T and Hohmann, C and Lau, S and Wahn, U and Heinrich, J and Tischer, CG and Fantini, MP and Lenzi, J and Porta, D and Koppelman, GH and Postma, DS and Berdel, D and Koletzko, S and Kerkhof, M and Gehring, U and Wickman, M and Mel{\'e}n, E and Hallberg, J and Bindslev-Jensen, C and Eller, E and Kull, I and L{\o}drup Carlsen, KC and Carlsen, K-H and Lambrecht, Bart and Kogevinas, M and Sunyer, J and Kauffmann, F and Bousquet, J and Ant{\'o}, JM},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keyword      = {eczema,rhinitis,LATENT CLASS ANALYSIS,ATOPIC-DERMATITIS,CHILDHOOD ASTHMA,ASSOCIATIONS,PREVENTION,COUGH,SENSITIZATION,ORGANIZATION,MECHANISMS,SYMPTOMS,cluster analysis,asthma,allergy},
  language     = {eng},
  number       = {8},
  pages        = {973--984},
  title        = {Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster},
  url          = {http://dx.doi.org/10.1111/all.12640},
  volume       = {70},
  year         = {2015},
}

Chicago
Garcia-Aymerich, J, M Benet, Yvan Saeys, M Pinart, X Basagaña, HA Smit, V Siroux, et al. 2015. “Phenotyping Asthma, Rhinitis and Eczema in MeDALL Population-based Birth Cohorts: An Allergic Comorbidity Cluster.” Allergy 70 (8): 973–984.
APA
Garcia-Aymerich, J., Benet, M., Saeys, Y., Pinart, M., Basagaña, X., Smit, H., Siroux, V., et al. (2015). Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. ALLERGY, 70(8), 973–984.
Vancouver
1.
Garcia-Aymerich J, Benet M, Saeys Y, Pinart M, Basagaña X, Smit H, et al. Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. ALLERGY. 2015;70(8):973–84.
MLA
Garcia-Aymerich, J, M Benet, Yvan Saeys, et al. “Phenotyping Asthma, Rhinitis and Eczema in MeDALL Population-based Birth Cohorts: An Allergic Comorbidity Cluster.” ALLERGY 70.8 (2015): 973–984. Print.