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Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) SCIENCE. 349(6252). p.1106-1110
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)-rich environment with protection has remained elusive. Here we show that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite (HDM)-induced asthma. Endotoxin reduced epithelial cell cytokines that activate dendritic cells (DCs), thus suppressing type 2 immunity to HDMs. Loss of the ubiquitin-modifying enzyme A20 in lung epithelium abolished the protective effect. A single-nucleotide polymorphism in the gene encoding A20 was associated with allergy and asthma risk in children growing up on farms. Thus, the farming environment protects from allergy by modifying the communication between barrier epithelial cells and DCs through A20 induction.
Keywords
AIRWAY INFLAMMATION, CHILDHOOD ASTHMA, NF-KAPPA-B, MITE ALLERGEN, ENZYME A20, EXPOSURE, RESPONSES, CHILDREN, IMMUNITY, ENVIRONMENT

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Citation

Please use this url to cite or link to this publication:

MLA
Schuijs, Martijn et al. “Farm Dust and Endotoxin Protect Against Allergy Through A20 Induction in Lung Epithelial Cells.” SCIENCE 349.6252 (2015): 1106–1110. Print.
APA
Schuijs, M., Willart, M., Vergote, K., Gras, D., Deswarte, K., Ege, M. J., Branco Madeira, F., et al. (2015). Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. SCIENCE, 349(6252), 1106–1110.
Chicago author-date
Schuijs, Martijn, Monique Willart, Karl Vergote, Delphine Gras, Kim Deswarte, Markus J Ege, Filipe Branco Madeira, et al. 2015. “Farm Dust and Endotoxin Protect Against Allergy Through A20 Induction in Lung Epithelial Cells.” Science 349 (6252): 1106–1110.
Chicago author-date (all authors)
Schuijs, Martijn, Monique Willart, Karl Vergote, Delphine Gras, Kim Deswarte, Markus J Ege, Filipe Branco Madeira, Rudi Beyaert, Geert van Loo, Franz Bracher, Erika von Mutius, Pascal Chanez, Bart Lambrecht, and Hamida Hammad. 2015. “Farm Dust and Endotoxin Protect Against Allergy Through A20 Induction in Lung Epithelial Cells.” Science 349 (6252): 1106–1110.
Vancouver
1.
Schuijs M, Willart M, Vergote K, Gras D, Deswarte K, Ege MJ, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells. SCIENCE. 2015;349(6252):1106–10.
IEEE
[1]
M. Schuijs et al., “Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells,” SCIENCE, vol. 349, no. 6252, pp. 1106–1110, 2015.
@article{6971236,
  abstract     = {Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)-rich environment with protection has remained elusive. Here we show that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite (HDM)-induced asthma. Endotoxin reduced epithelial cell cytokines that activate dendritic cells (DCs), thus suppressing type 2 immunity to HDMs. Loss of the ubiquitin-modifying enzyme A20 in lung epithelium abolished the protective effect. A single-nucleotide polymorphism in the gene encoding A20 was associated with allergy and asthma risk in children growing up on farms. Thus, the farming environment protects from allergy by modifying the communication between barrier epithelial cells and DCs through A20 induction.},
  author       = {Schuijs, Martijn and Willart, Monique and Vergote, Karl and Gras, Delphine and Deswarte, Kim and Ege, Markus J and Branco Madeira, Filipe and Beyaert, Rudi and van Loo, Geert and Bracher, Franz and von Mutius, Erika and Chanez, Pascal and Lambrecht, Bart and Hammad, Hamida},
  issn         = {0036-8075},
  journal      = {SCIENCE},
  keywords     = {AIRWAY INFLAMMATION,CHILDHOOD ASTHMA,NF-KAPPA-B,MITE ALLERGEN,ENZYME A20,EXPOSURE,RESPONSES,CHILDREN,IMMUNITY,ENVIRONMENT},
  language     = {eng},
  number       = {6252},
  pages        = {1106--1110},
  title        = {Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells},
  url          = {http://dx.doi.org/10.1126/science.aac6623},
  volume       = {349},
  year         = {2015},
}

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