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Improving folate (vitamin B-9) stability in biofortified rice through metabolic engineering

Dieter Blancquaert, Jeroen Van Daele, Simon Strobbe UGent, Filip Kiekens, Serguei Storojenko UGent, Hans De Steur UGent, Xavier Gellynck UGent, Willy Lambert, Christophe Stove UGent and Dominique Van Der Straeten UGent (2015) NATURE BIOTECHNOLOGY. 33(10). p.1076-1078
abstract
Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EXPRESSION, HEALTH, FOLIC-ACID, TIME QUANTITATIVE PCR, IMPACT, GENES, ENHANCEMENT, FRAMEWORK, SEQUENCE, CHINA
journal title
NATURE BIOTECHNOLOGY
Nat. Biotechnol.
volume
33
issue
10
pages
1076 - 1078
Web of Science type
Article
Web of Science id
000362555700027
JCR category
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
JCR impact factor
43.113 (2015)
JCR rank
2/161 (2015)
JCR quartile
1 (2015)
ISSN
1087-0156
DOI
10.1038/nbt.3358
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
6971030
handle
http://hdl.handle.net/1854/LU-6971030
date created
2015-10-30 09:23:00
date last changed
2016-12-19 15:42:05
@article{6971030,
  abstract     = {Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains.},
  author       = {Blancquaert, Dieter and Van Daele, Jeroen and Strobbe, Simon and Kiekens, Filip and Storojenko, Serguei and De Steur, Hans and Gellynck, Xavier and Lambert, Willy and Stove, Christophe and Van Der Straeten, Dominique},
  issn         = {1087-0156},
  journal      = {NATURE BIOTECHNOLOGY},
  keyword      = {EXPRESSION,HEALTH,FOLIC-ACID,TIME QUANTITATIVE PCR,IMPACT,GENES,ENHANCEMENT,FRAMEWORK,SEQUENCE,CHINA},
  language     = {eng},
  number       = {10},
  pages        = {1076--1078},
  title        = {Improving folate (vitamin B-9) stability in biofortified rice through metabolic engineering},
  url          = {http://dx.doi.org/10.1038/nbt.3358},
  volume       = {33},
  year         = {2015},
}

Chicago
Blancquaert, Dieter, Jeroen Van Daele, Simon Strobbe, Filip Kiekens, Serguei Storojenko, Hans De Steur, Xavier Gellynck, Willy Lambert, Christophe Stove, and Dominique Van Der Straeten. 2015. “Improving Folate (vitamin B-9) Stability in Biofortified Rice Through Metabolic Engineering.” Nature Biotechnology 33 (10): 1076–1078.
APA
Blancquaert, D., Van Daele, J., Strobbe, S., Kiekens, F., Storojenko, S., De Steur, H., Gellynck, X., et al. (2015). Improving folate (vitamin B-9) stability in biofortified rice through metabolic engineering. NATURE BIOTECHNOLOGY, 33(10), 1076–1078.
Vancouver
1.
Blancquaert D, Van Daele J, Strobbe S, Kiekens F, Storojenko S, De Steur H, et al. Improving folate (vitamin B-9) stability in biofortified rice through metabolic engineering. NATURE BIOTECHNOLOGY. 2015;33(10):1076–8.
MLA
Blancquaert, Dieter, Jeroen Van Daele, Simon Strobbe, et al. “Improving Folate (vitamin B-9) Stability in Biofortified Rice Through Metabolic Engineering.” NATURE BIOTECHNOLOGY 33.10 (2015): 1076–1078. Print.