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Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes

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Abstract
This paper addresses the estimation of the specific production rate of intracellular products and the modeling of the bioreactor volume dynamics in high cell density fed-batch reactors. In particular, a new model for the bioreactor volume is proposed, suitable to be used in high cell density cultures where large amounts of intracellular products are stored. Based on the proposed volume model, two forms of a high-order sliding mode observer are proposed. Each form corresponds to the cases with residual biomass concentration or volume measurement, respectively. The observers achieve finite time convergence and robustness to process uncertainties as the kinetic model is not required. Stability proofs for the proposed observer are given. The observer algorithm is assessed numerically and experimentally.
Keywords
Volume model, RHODOSPORIDIUM-TORULOIDES Y4, Estimation, High cell density, Observer, Sliding mode, FED-BATCH PROCESSES, BIOPROCESS CONTROL, KINETIC RATES, OBSERVER, CULTURE, POLYHYDROXYALKANOATES, CULTIVATION

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MLA
Jamilis, Martín et al. “Modeling and Estimation of Production Rate for the Production Phase of Non-growth-associated High Cell Density Processes.” BIOPROCESS AND BIOSYSTEMS ENGINEERING 38.10 (2015): 1903–1914. Print.
APA
Jamilis, M., Garelli, F., Mozumder, M. S. I., Castañeda, T., & De Battista, H. (2015). Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes. BIOPROCESS AND BIOSYSTEMS ENGINEERING, 38(10), 1903–1914.
Chicago author-date
Jamilis, Martín, Fabricio Garelli, Md. Salatul Islam Mozumder, Teresita Castañeda, and Hernán De Battista. 2015. “Modeling and Estimation of Production Rate for the Production Phase of Non-growth-associated High Cell Density Processes.” Bioprocess and Biosystems Engineering 38 (10): 1903–1914.
Chicago author-date (all authors)
Jamilis, Martín, Fabricio Garelli, Md. Salatul Islam Mozumder, Teresita Castañeda, and Hernán De Battista. 2015. “Modeling and Estimation of Production Rate for the Production Phase of Non-growth-associated High Cell Density Processes.” Bioprocess and Biosystems Engineering 38 (10): 1903–1914.
Vancouver
1.
Jamilis M, Garelli F, Mozumder MSI, Castañeda T, De Battista H. Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 2015;38(10):1903–14.
IEEE
[1]
M. Jamilis, F. Garelli, M. S. I. Mozumder, T. Castañeda, and H. De Battista, “Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes,” BIOPROCESS AND BIOSYSTEMS ENGINEERING, vol. 38, no. 10, pp. 1903–1914, 2015.
@article{6967078,
  abstract     = {This paper addresses the estimation of the specific production rate of intracellular products and the modeling of the bioreactor volume dynamics in high cell density fed-batch reactors. In particular, a new model for the bioreactor volume is proposed, suitable to be used in high cell density cultures where large amounts of intracellular products are stored. Based on the proposed volume model, two forms of a high-order sliding mode observer are proposed. Each form corresponds to the cases with residual biomass concentration or volume measurement, respectively. The observers achieve finite time convergence and robustness to process uncertainties as the kinetic model is not required. Stability proofs for the proposed observer are given. The observer algorithm is assessed numerically and experimentally.},
  author       = {Jamilis, Martín and  Garelli, Fabricio and Mozumder, Md. Salatul Islam and  Castañeda, Teresita and  De Battista, Hernán},
  issn         = {1615-7591},
  journal      = {BIOPROCESS AND BIOSYSTEMS ENGINEERING},
  keywords     = {Volume model,RHODOSPORIDIUM-TORULOIDES Y4,Estimation,High cell density,Observer,Sliding mode,FED-BATCH PROCESSES,BIOPROCESS CONTROL,KINETIC RATES,OBSERVER,CULTURE,POLYHYDROXYALKANOATES,CULTIVATION},
  language     = {eng},
  number       = {10},
  pages        = {1903--1914},
  title        = {Modeling and estimation of production rate for the production phase of non-growth-associated high cell density processes},
  url          = {http://dx.doi.org/10.1007/s00449-015-1430-7},
  volume       = {38},
  year         = {2015},
}

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