Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger
- Author
- Joke Devoldere (UGent) , Heleen Dewitte (UGent) , Stefaan De Smedt (UGent) and Katrien Remaut (UGent)
- Organization
- Abstract
- In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits an innate immune response which has favored mRNA use towards immunotherapeutic vaccination strategies. However, for non-immunotherapy related applications this intrinsic immune-stimulatory activity directly interferes with the aimed therapeutic outcome, as it can seriously compromise the expression of the desired protein. This review presents an overview of the immune-related obstacles that limit mRNA advance for non-immunotherapy related applications.
- Keywords
- mRNA-based reprogramming, Non-viral delivery, DEPENDENT PROTEIN-KINASE, INTERFERON-GAMMA PRODUCTION, PLURIPOTENT STEM-CELLS, mRNA therapy, Immune-inhibition, Innate immunity, Protein-replacement therapy, DOUBLE-STRANDED-RNA, NF-KAPPA-B, TOLL-LIKE RECEPTOR-3, CYTOTOXIC T-LYMPHOCYTES, RIG-I, ANTIVIRAL RESPONSES, DENDRITIC CELLS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-6965527
- MLA
- Devoldere, Joke, Heleen Dewitte, Stefaan De Smedt, et al. “Evading Innate Immunity in Nonviral mRNA Delivery : Don’t Shoot the Messenger.” DRUG DISCOVERY TODAY 21.1 (2016): 11–25. Print.
- APA
- Devoldere, J., Dewitte, H., De Smedt, S., & Remaut, K. (2016). Evading innate immunity in nonviral mRNA delivery : don’t shoot the messenger. DRUG DISCOVERY TODAY, 21(1), 11–25.
- Chicago author-date
- Devoldere, Joke, Heleen Dewitte, Stefaan De Smedt, and Katrien Remaut. 2016. “Evading Innate Immunity in Nonviral mRNA Delivery : Don’t Shoot the Messenger.” Drug Discovery Today 21 (1): 11–25.
- Chicago author-date (all authors)
- Devoldere, Joke, Heleen Dewitte, Stefaan De Smedt, and Katrien Remaut. 2016. “Evading Innate Immunity in Nonviral mRNA Delivery : Don’t Shoot the Messenger.” Drug Discovery Today 21 (1): 11–25.
- Vancouver
- 1.Devoldere J, Dewitte H, De Smedt S, Remaut K. Evading innate immunity in nonviral mRNA delivery : don’t shoot the messenger. DRUG DISCOVERY TODAY. 2016;21(1):11–25.
- IEEE
- [1]J. Devoldere, H. Dewitte, S. De Smedt, and K. Remaut, “Evading innate immunity in nonviral mRNA delivery : don’t shoot the messenger,” DRUG DISCOVERY TODAY, vol. 21, no. 1, pp. 11–25, 2016.
@article{6965527,
abstract = {In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits an innate immune response which has favored mRNA use towards immunotherapeutic vaccination strategies. However, for non-immunotherapy related applications this intrinsic immune-stimulatory activity directly interferes with the aimed therapeutic outcome, as it can seriously compromise the expression of the desired protein. This review presents an overview of the immune-related obstacles that limit mRNA advance for non-immunotherapy related applications.},
author = {Devoldere, Joke and Dewitte, Heleen and De Smedt, Stefaan and Remaut, Katrien},
issn = {1359-6446},
journal = {DRUG DISCOVERY TODAY},
keywords = {mRNA-based reprogramming,Non-viral delivery,DEPENDENT PROTEIN-KINASE,INTERFERON-GAMMA PRODUCTION,PLURIPOTENT STEM-CELLS,mRNA therapy,Immune-inhibition,Innate immunity,Protein-replacement therapy,DOUBLE-STRANDED-RNA,NF-KAPPA-B,TOLL-LIKE RECEPTOR-3,CYTOTOXIC T-LYMPHOCYTES,RIG-I,ANTIVIRAL RESPONSES,DENDRITIC CELLS},
language = {eng},
number = {1},
pages = {11--25},
title = {Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger},
url = {http://dx.doi.org/10.1016/j.drudis.2015.07.009},
volume = {21},
year = {2016},
}
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