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Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger

Joke Devoldere (UGent) , Heleen Dewitte (UGent) , Stefaan De Smedt (UGent) and Katrien Remaut (UGent)
(2016) DRUG DISCOVERY TODAY. 21(1). p.11-25
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Abstract
In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits an innate immune response which has favored mRNA use towards immunotherapeutic vaccination strategies. However, for non-immunotherapy related applications this intrinsic immune-stimulatory activity directly interferes with the aimed therapeutic outcome, as it can seriously compromise the expression of the desired protein. This review presents an overview of the immune-related obstacles that limit mRNA advance for non-immunotherapy related applications.
Keywords
mRNA-based reprogramming, Non-viral delivery, DEPENDENT PROTEIN-KINASE, INTERFERON-GAMMA PRODUCTION, PLURIPOTENT STEM-CELLS, mRNA therapy, Immune-inhibition, Innate immunity, Protein-replacement therapy, DOUBLE-STRANDED-RNA, NF-KAPPA-B, TOLL-LIKE RECEPTOR-3, CYTOTOXIC T-LYMPHOCYTES, RIG-I, ANTIVIRAL RESPONSES, DENDRITIC CELLS

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Citation

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Chicago
Devoldere, Joke, Heleen Dewitte, Stefaan De Smedt, and Katrien Remaut. 2016. “Evading Innate Immunity in Nonviral mRNA Delivery : Don’t Shoot the Messenger.” Drug Discovery Today 21 (1): 11–25.
APA
Devoldere, J., Dewitte, H., De Smedt, S., & Remaut, K. (2016). Evading innate immunity in nonviral mRNA delivery : don’t shoot the messenger. DRUG DISCOVERY TODAY, 21(1), 11–25.
Vancouver
1.
Devoldere J, Dewitte H, De Smedt S, Remaut K. Evading innate immunity in nonviral mRNA delivery : don’t shoot the messenger. DRUG DISCOVERY TODAY. 2016;21(1):11–25.
MLA
Devoldere, Joke, Heleen Dewitte, Stefaan De Smedt, et al. “Evading Innate Immunity in Nonviral mRNA Delivery : Don’t Shoot the Messenger.” DRUG DISCOVERY TODAY 21.1 (2016): 11–25. Print.
@article{6965527,
  abstract     = {In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits an innate immune response which has favored mRNA use towards immunotherapeutic vaccination strategies. However, for non-immunotherapy related applications this intrinsic immune-stimulatory activity directly interferes with the aimed therapeutic outcome, as it can seriously compromise the expression of the desired protein. This review presents an overview of the immune-related obstacles that limit mRNA advance for non-immunotherapy related applications.},
  author       = {Devoldere, Joke and Dewitte, Heleen and De Smedt, Stefaan and Remaut, Katrien},
  issn         = {1359-6446},
  journal      = {DRUG DISCOVERY TODAY},
  language     = {eng},
  number       = {1},
  pages        = {11--25},
  title        = {Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger},
  url          = {http://dx.doi.org/10.1016/j.drudis.2015.07.009},
  volume       = {21},
  year         = {2016},
}
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